Effect of Petroleum Ether Fractions of Morinda lucida on Plasmodium berghei berghei in Mice

Abstract

Efforts were made to evaluate the antimalarial activity of fractions obtained from Morinda lucida, a local medicinal plant commonly used against fever. The March and June samples of the plant were screened against Plasmodium berghei berghei in mice. The fractions demonstrated schizontocidal activity against early infection, with fraction A of the March and June samples giving the highest chemosuppression. The fractions showed less activity when evaluated for repository effect, while some of the fractions of the samples proved active against established infections.

Ethnobotanical survey for potential anti-malarial plants in south-western Nigeria

“…Of these, 5 have been previously investigated (Table 3). Previous in vitro and in vivo studies show that Cymbopogon citratus (Tchoumbougnang et al, 2005), Morinda lucida (Awe and Makinde, 1998) and Azadirachta indica (Bidla et al, 2004), which are always used in combination, have significant anti-malarial activity. However, Morinda lucida, though found to be frequently employed traditionally, showed high in vitro cytotoxicity based on studies carried out by Ajaiyeoba et al (2006), whereas Cymbopogon citratus showed insignificant cytotoxicity (Iwu, 1993).…”

“…Brimstone tree Ezeogu, Oruwo, idonzakara Leaves, bark Used to treat sores, abscesses, Leprosy, ringworm, fever, jaundice and dysentery (Odugbemi et al, 2007;Awe andMakinde, 1998 andIwu., 1993) Ethanol 15 alkaloids A related species Alstoniaboonei has been tested and prepared as tablet Majekodunmi et al, 2008 andKayode et al, 2009 Carica papaya L.…”

A review of twenty ethnobotanicals used in the management of breast cancer in Abeokuta, Ogun State, Nigeria

“…The leaves and bark showed cardio-activity in animal tests (Ilesanmi et al, 1988). The methanolic leaf extract displayed some antimalaria activity against Plasmodium berghei in mice (Awe and Poeke, 1990). Acute and sub-acute toxicity of A. congensis bark and X. aethiopica fruit mixtures in Swiss albino rats based on the claimed use in the treatment of diabetes, revealed the tendency of kidney problems on a long term use (Ogbonnia et al, 2008).…”

Exploratory Research Antimalarial Properties Alstonia Congensis - the Pilot Survey Results Conducted in Kenge, Province Kwango DRC

“…For its part, Khyade et al [29] had demonstrated qu' Alstonia scholaris and Alstonia macrophylla are both rich in various types of bioactive alkaloids and contain a broad spectrum of biological and pharmacological activity in vitro and in vivo. This could be for Alstonia congensis future AWE et al [16]. It is noteworthy that the decoction of Alstonia contains an active anti pyretic confirmed with further study because, among patients treated Rare were those who associated anti pyretic.…”

“…His study was conducted to evaluate the activity of the extract antiplasmodial Alstonia of methanol root bark on boonei Infection with Plasmodium berghei berghei chloroquine-sensitive mice to justify its use as an antimalarial remedy in Nigeria. The plant extract was screened for blood schizontocide activity against Plasmodium berghei infection sensitive to chloroquine in the mouse AWE and Poeke [16].…”