Effect of petroleum ether extract of Panax ginseng roots on proliferation and cell cycle progression of human renal cell carcinoma cells

Sohn, Jeongwon; Lee, Chulhee; Chung, Dong Jun; Park, Sul Hee; Kim, Insun; Hwang, Woo Ik

doi:10.1038/emm.1998.7

Cited by 33 publications

(20 citation statements)

References 7 publications

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“…Rh2 and Rg3 suppressed breast, prostate, liver and intestinal cancer [11,[48][49][50][51][52][53] . The anti-proliferative effects of petroleum ether extract of P ginseng in cultured human renal cell carcinoma cell lines were demonstrated; even its potency was weaker than partially purified P ginseng preparation, panaxydol, and some as panazynol [54] . Therefore, additive or synergic anticancer effects of different bioactive components in P ginseng must occur.…”

Section: Pharmacologymentioning

confidence: 99%

Comparison of the pharmacological effects ofPanax ginsengandPanax quinquefolium

Chen¹,

Chiou²,

Zhang

2008

Acta Pharmacologica Sinica

231

139

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Medical application of Panax ginseng was first found in "Shen-Nong Herbal Classic" around 200 AD Panax quinquefolium was first introduced in "Essential of Materia Medica" in 1694 in China. The most important bioactive components contained in P ginseng and P quinquefolium are ginseng saponins (GS). The contents of ginsenoside Rb1, Re, and Rd in P quinquefolium are higher than they are in P ginseng. In P ginseng, the contents of Rg1,Rb2, and Rc are higher than they are in P quinquefolium. P ginseng had a higher ratio of Rg1: Rb1, and which was lower in P quinquefolium. After steaming for several hours, the total GS will decrease. However, some ginsenosides (Rg2, 20R-Rg2, Rg3, Rh1 and Rh2) increase, while others (Rb1, Rb2, Rb3, Rc, Rd, Re, and Rg1) decrease. However, variation, especially in P quinquefolium, is high. P ginseng and P quinquefolium are general tonics and adaptogens. Rg1 and Rb1 enhance central nervous system (CNS) activities, but the effect of the latter is weaker. Thus, for the higher contents of Rg1, P ginseng is a stimulant, whereas the Rb1 contents of P quinquefolium are mainly calming to the CNS. Re, Rg1, panaxan A and B from P ginseng are good for diabetes. Re and Rg1 enhance angiogenesis, whereas Rb1, Rg3 and Rh2 inhibit it. Rh2, an antitumor agent, can be obtained from Rb1 by steaming. The content of Re in P quinquefolium are higher than in P ginseng by 3-4 times. The vasorelax, antioxidant, antihyperlipidemic, and angiogenic effects of Re are reported. Thus, for the CNS "hot," wound healing and hypoglycemic effects, P ginseng is better than P quinquefolium. For anticancer effects, P quinquefolium is better.

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Section: Pharmacologymentioning

confidence: 99%

Comparison of the pharmacological effects ofPanax ginsengandPanax quinquefolium

Chen¹,

Chiou²,

Zhang

2008

Acta Pharmacologica Sinica

231

139

View full text Add to dashboard Cite

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“…Cells were incubated with human recombinant IL-4 (Biosource International, Camarillo, CA), and analyzed for the cell cycle distribution as described previously (Sohn et al, 1998). Briefly, cells were fixed in 70% ethanol overnight at -20 o C, washed with phosphate bufferd saline (PBS), and suspended in PBS containing 200 µg/ml RNase A and 20 µg/ml propidium iodide.…”

Section: Cell Cycle Analysismentioning

confidence: 99%

IL-4 inhibits proliferation of renal carcinoma cells by increasing the expression of p21WAF1 and IRF-1

Kim²,

Cho³

et al. 2004

Exp Mol Med

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“…인삼의 지용성 성분이 암세포 증식을 현저히 억제하거나 사멸시키는 작용이 있음이 보고된 이후 4,5) , 이를 근거로 인삼의 지용성 성분으로부터 유효성분으 로서 polyacethylene계 화합물을 인정하게 되었다. 현재까지 9종의 polyacethylene계 성분을 분리 동정하였는데 6,7) , 인삼 중 지용성 성분의 항암 효과는 주로 panaxynol과 panaxydol 에 기인된 것으로 알려졌고 8,9) , 이후 동물실험을 통해 인삼의 지용성 성분이 in vivo에서도 항암 및 면역증강 효과를 나타 냄을 확인한 바 있다 10,11) .…”

Section: 서 론unclassified

Effects of Lipid Soluble Ginseng Extract on Immune Response

2008

Journal of Ginseng Research

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: Lipid soluble ginseng extract was administered by oral route in doses of 600 mg/patient daily in cancer patients over 2 months and 6 months. The administration of ginseng extract in cancer patients maintained the ratio of CD4/CD8 and number of the natural killer cell in the normal range during the administration period. Also its administration showed a positive effect on tumor values in 87.5% of patients in 2 month-group and in 50% of patients in 6 month-group, as determined by various cancer markers. Liver and kidney functions maintained normal condition during administration period of 6 months. Although there was no statistical significance, these data suggest that lipid soluble ginseng extract may be useful as an adjuvant therapeutic agent and nutritional supplement for the improvement of immune function and health in cancer patients. This study would provide the basis for the research in which the antitumor and immunopotential activity of lipid soluble ginseng extract for cancer patients are evaluated in formal clinical trial with statistically significant patient number.

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Effect of petroleum ether extract of Panax ginseng roots on proliferation and cell cycle progression of human renal cell carcinoma cells

Cited by 33 publications

References 7 publications

Comparison of the pharmacological effects ofPanax ginsengandPanax quinquefolium

Comparison of the pharmacological effects ofPanax ginsengandPanax quinquefolium

IL-4 inhibits proliferation of renal carcinoma cells by increasing the expression of p21WAF1 and IRF-1

Effects of Lipid Soluble Ginseng Extract on Immune Response

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