Effect of pesticide exposure on HER-2/<i>neu</i> and CD117 overexpression in patients with extensive stage small cell lung carcinoma (ESSCLC)

Potti, Anil; Ganti, Apar Kishor; Koch, M.; Kargas, Steve A.

doi:10.1200/jco.2004.22.90140.9629a

Cited by 7 publications

(11 citation statements)

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“…In this case, the lineage markers including CD3, B220, CD11b, Gr‐1, Ter‐119 and NK1.1 were all up‐regulated concomitantly with up‐regulation of HSC markers c‐kit and Sca‐1 [98]. c‐kit, a transmembrane tyrosine kinase receptor encoded by proto‐oncogene c‐kit, and Sca‐1, a glycosylphos‐phatidylinositol‐ linked cell surface protein, have been identified as markers of cancer progression in various types of non‐haematopoietic cancers [100–102]. Thus, c‐kit and Sca‐1 are unlikely the predictors for CSCs.…”

Section: Clonal Evolution Underlies the Development Of Tics → Pcscs →mentioning

confidence: 99%

“…The haematopoietic murine pCSC lines established in our laboratory are CD45 [93][94][95][96], is ubiquitously expressed on pCSCs and CSCs. CD117 (c-kit) and Sca-1 (stem cell antigen-1), which are the markers for HSCs [97][98][99], have been implicated as markers for progression of various types of cancer [100][101][102]. In contrast to HSCs [97,98], both the pCSCs and CSCs isolated from murine lymphoma and thymoma, respectively, did not express CD117 and Sca-1, both of which, however, were up-regulated when pCSCs were progressing to cancer [2], consistently with clinical observations of human cancers [100][101][102].…”

Section: Conserved Versus Volatile Phenotypes For Pre-cancerous and Cmentioning

confidence: 99%

See 1 more Smart Citation

Cancer stem cells: the lessons from pre‐cancerous stem cells

Gao¹

2007

J Cellular Molecular Medi

111

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How a cancer is initiated and established remains elusive despite all the advances in decades of cancer research. Recently the cancer stem cell (CSC) hypothesis has been revived, challenging the long-standing model of ‘clonal evolution’ for cancer development and implicating the dawning of a potential cure for cancer [1]. The recent identification of pre-cancerous stem cells (pCSCs) in cancer, an early stage of CSC development, however, implicates that the clonal evolution is not contradictory to the CSC hypothesis but is rather an aspect of the process of CSC development [2]. The discovery of pCSC has revealed and will continue to reveal the volatile properties of CSC with respect to their phenotype, differentiation and tumourigenic capacity during initiation and progression. Both pCSC and CSC might also serve as precursors of tumour stromal components such as tumour vasculogenic stem/progenitor cells (TVPCs). Thus, the CSC hypothesis covers the developing process of tumour-initiating cells (TIC) → pCSC → CSC → cancer, a cellular process that should parallel the histological process of hyperplasia/metaplasia (TIC) → pre-cancerous lesions (pCSC) → malignant lesions (CSC → cancer). The embryonic stem (ES) cell and germ line stem (GS) cell genes are subverted in pCSCs. Especially the GS cell protein piwil2 may play an important role during the development of TIC → pCSC → CSC, and this protein may be used as a common biomarker for early detection, prevention, and treatment of cancer. As cancer stem cell research is yet in its infancy, definitive conclusions regarding the role of pCSC cannot be made at this time. However, this review will discuss what we have learned from pCSC and how this has led to innovative ideas that may eventually have major impacts on the understanding and treatment of cancer.

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Section: Clonal Evolution Underlies the Development Of Tics → Pcscs →mentioning

confidence: 99%

Section: Conserved Versus Volatile Phenotypes For Pre-cancerous and Cmentioning

confidence: 99%

Cancer stem cells: the lessons from pre‐cancerous stem cells

Gao¹

2007

J Cellular Molecular Medi

111

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“…In a specific case, it was observed that HER-2/neu oncoprotein is overexpressed in patients with extensivestage small cell lung cancer and is associated with decreased survival, and it was also observed that pesticide exposure seemed to be related to HER-2/neu overexpression in the study population (Potti et al, 2003). Similarly, an interaction between organophosphate pesticide exposure and PON1 activity on thyroid function in a population of floriculture workers from Mexico was observed (Lacasaña et al, 2010).…”

Section: Wwwintechopencommentioning

confidence: 87%

Pesticide Biomarkers

AE¹,

IM²,

ML³

et al. 2011

Pesticides in the Modern World - Pests Control and Pesticides Exposure and Toxicity Assessment

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“…4,10,[22][23][24] Her-2/neu expression was reported in 13-80% in adenocarcinomas, 17,22,24 in 2-45% in squamous cell carcinomas, 15,16,18 in 0-20% in large-cell carcinomas 23 and in 13-31% in small cell lung carcinomas. 4,25,26 features under the study including sex, age, smoking history and tumour differentiation (well, moderately and poorly). We found the correlation between HER-2/neu expression and performance status (x²=14.1; p<0.006).…”

Section: Discussionmentioning

confidence: 99%