Effect of Perioperative Terlipressin on Postoperative Renal Function in Patients Who Have Undergone Living Donor Liver Transplantation: A Meta-Analysis of Randomized Controlled Trials

Won, Young Ju; Kim, H. J.; Lim, Byung Gun; Ahn, Hyun Soo; Hwang, Myung Jin

doi:10.1016/j.transproceed.2015.06.023

Cited by 11 publications

(18 citation statements)

References 25 publications

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“…These findings were further supported by a meta‐analysis performed by Won et al . analyzing the findings of several studies including two of the above‐mentioned studies, Fayed et al .…”

Section: Discussionsupporting

confidence: 52%

“…These findings were further supported by a meta-analysis performed by Won et al 15 analyzing the findings of several studies including two of the above-mentioned studies, Fayed et al 14 reperfusion while increases in COP can be blunted. 16 Terlipressin use can be of help to maintain SVR as explained in the above paragraph.…”

Section: Discussionmentioning

confidence: 67%

“…and came to the same and similar conclusions of the current RCT in which the serum creatinine, creatinine clearance, and urine output were not affected by the terlipressin infusion. This meta‐analysis study conducted by Won et al . is considered a step up further in the evidence‐based ladder and is considered ahead of the retrospective designed study of Mukhtar et al …”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Impact of terlipressin infusion during and after live donor liver transplantation on incidence of acute kidney injury and neutrophil gelatinase‐associated lipocalin serum levels: A randomized controlled trial

Kandil

Abouelenain

Alsebaey

et al. 2017

Clinical Transplantation

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“…These findings were further supported by a meta‐analysis performed by Won et al . analyzing the findings of several studies including two of the above‐mentioned studies, Fayed et al .…”

Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of terlipressin infusion during and after live donor liver transplantation on incidence of acute kidney injury and neutrophil gelatinase‐associated lipocalin serum levels: A randomized controlled trial

Kandil

Abouelenain

Alsebaey

et al. 2017

Clinical Transplantation

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show abstract

“…It is unclear whether no observed side effects occurred or whether researchers did not actively look for them. A recent meta‐analysis of Tp in LDLT highlighted both the nonblinded aspect of these studies and the lack of any adverse effects–related information . Our data attempt to bridge some of these deficiencies.…”

Section: Discussionmentioning

confidence: 96%

Double‐blind randomized controlled trial of the routine perioperative use of terlipressin in adult living donor liver transplantation

Reddy

Kaliamoorthy²,

Rajakumar³

et al. 2017

Liver Transpl

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Perioperative terlipressin (Tp) during living donor liver transplantation (LDLT) has been shown to reduce intraoperative portal pressures and improve renal function. Its role and safety profile have never been evaluated in a double-blind randomized controlled trial (RCT). The aim was to evaluate the hemodynamic effects, clinical benefits, and safety of perioperative Tp infusion in adult LDLT. This was a single-center double-blind RCT. Consenting adults with chronic liver disease and low risk of posttransplant renal dysfunction undergoing their first LDLT were randomized. The study group (terlipressin group [TpG]) received an initial bolus of Tp during surgery followed by a Tp infusion for 72 hours in the postoperative period. The placebo group (PbG) received a saline infusion. The primary endpoint was portal pressure after arterial reperfusion. Multiple intraoperative and postoperative variables served as secondary endpoints. A total of 41 patients were enrolled in the trial (TpG, 21; PbG, 20). There were no significant differences in intraoperative portal pressures, blood loss, fluid requirement, vasopressor requirement, or urine output. Peak intraoperative and end of surgery lactate levels were significantly higher in the Tp group. There was no difference in postoperative liver function tests. Incidence of acute kidney injury as assessed by Risk, Injury, Failure, Loss, and End-Stage Kidney Disease criteria was lower in the Tp group (27% versus 60%; P = 0.04). The TpG had less postoperative ascites, a lower need for percutaneous interventions, and a shorter hospital stay. Incidence of bradycardia requiring pharmacological intervention and withdrawal from study was significantly higher in the TpG. In conclusion, this study has not demonstrated a reduction in postreperfusion portal pressure with Tp. However, Tp infusion reduced postoperative ascitic drain output resulting in less frequent percutaneous interventions and reduced hospital stay. Intraoperative hyperlactatemia and symptomatic bradycardia are major concerns. Its use should be restricted to patients with high-volume ascites, and it needs close monitoring during drug infusion. Liver Transplantation 23 1007-1014 2017 AASLD.

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“…This study reiterates that terlipressin improves renal function . Because renal dysfunction can be due to multiple insults, including blood loss, prolonged surgery, renal ischemia, sepsis, and calcineurin inhibitors, use of terlipressin should be judicious and individualized .…”

mentioning

confidence: 75%

Perioperative use of terlipressin in adult liver transplant

Taneja¹,

Chawla²

2017

Liver Transpl

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Effect of Perioperative Terlipressin on Postoperative Renal Function in Patients Who Have Undergone Living Donor Liver Transplantation: A Meta-Analysis of Randomized Controlled Trials

Cited by 11 publications

References 25 publications

Impact of terlipressin infusion during and after live donor liver transplantation on incidence of acute kidney injury and neutrophil gelatinase‐associated lipocalin serum levels: A randomized controlled trial

Impact of terlipressin infusion during and after live donor liver transplantation on incidence of acute kidney injury and neutrophil gelatinase‐associated lipocalin serum levels: A randomized controlled trial

Double‐blind randomized controlled trial of the routine perioperative use of terlipressin in adult living donor liver transplantation

Perioperative use of terlipressin in adult liver transplant

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