Effect of perioperative systemic alpha2-agonists on postoperative morphine consumption and pain intensity - systematic review of randomized controlled trials

Optimizing pain management to facilitate Enhanced Recovery After Surgery pathways

“…A systematic review and meta-analysis confirmed that systemic a2 agonists (clonidine or dexmedetomidine) decrease postoperative opioid consumption, pain intensity, and opioid-related side effects (i.e., nausea) when added to an opioid-based regimen. 73 There is much variability in administration route (intravenous, oral, transdermal, and other routes) and time of administration (before, during, or after surgery), and more research is needed to ascertain the optimal route and dose timing. Clonidine is also a useful addition to multimodal regional anesthetic infusions.…”

Duration of analgesia, sensory and motor blockade and intra operative hemodynamic changes caused by intrathecal bupivacaine, bupivacaine plus clonidine and bupivacaine plus dexmedetomidine in spinal anesthesia: prospective, comparative study

“…The combination of Clonidine or Dexmedetomidine also allows for a reduction in the total dose of the local 1 Graded Specialist (anaesthesiology), Military Hospital Belgaum, Karnataka, India 2 Classified Specialist Anaesthesiology, Military Hospital Jaipur, Banipark, Rajasthan, India anaesthetic used, which translates into better hemodynamic stability intraoperatively. [7][8][9][10][11] Clonidine and Dexmedetomidine have also been shown to have significant analgesic effect in the postoperative duration much after the regression of the motor blockade which allows for early and pain free ambulation. [9][10][11] In the view of these facts, this study is planned to differentiate the effects of Dexmedetomidine and clonidine on duration of analgesia, motor and sensory blockade and the intraoperative hemodynamic profile when mixed with Bupivacaine.…”

“…[7][8][9][10][11] Clonidine and Dexmedetomidine have also been shown to have significant analgesic effect in the postoperative duration much after the regression of the motor blockade which allows for early and pain free ambulation. [9][10][11] In the view of these facts, this study is planned to differentiate the effects of Dexmedetomidine and clonidine on duration of analgesia, motor and sensory blockade and the intraoperative hemodynamic profile when mixed with Bupivacaine. This study also aims to ascertain the safety of these drugs for use in routine practice in the hospital.…”

Effect of Different Doses of Dexmedetomidine on Stress Response and Emergence Agitation after Laparoscopic Cholecystectomy: Randomized Controlled Double-Blind Study

“…Dexmedetomidine decreases the postoperative supplemental analgesic requirements and pain intensity. Information about dexmedetomidine and EA is limited especially in adult patients [10].…”