Effect of perioperative intravenous lidocaine on postoperative outcomes in patients undergoing resection of colorectal cancer: a protocol for systematic review and meta-analysis

Abstract

IntroductionTechniques using local anaesthetics provide high-quality analgesia, while the anti-inflammatory properties of these drugs may represent an additional advantage. Perioperative intravenous lidocaine has shown positive effects not only on postoperative pain but also on bowel function and duration of hospital stay, due to its analgesic, anti-inflammatory and opioid-sparing effects. However, these potential benefits are not well established in patients undergoing resection with colorectal cancer. This research aims to determine the effect of perioperative intravenous lidocaine on postoperative outcomes in patients undergoing resection of colorectal cancer.Methods and analysisPubMed, Embase, Web of Science, CNKI, SinoMed and WanFang Data databases were electronically retrieved to include the randomised controlled trials comparing perioperative intravenous lidocaine with placebo infusion in patients undergoing resection of colorectal cancer before August 2021. Registers of clinical trials, potential grey literature and abstracts from conferences will also be searched. Two reviewers will screen literature, extract data and assess risk of bias of studies included independently. The primary outcome variable will be long-term survival outcome, tumour recurrence and metastasis rate, and restoration of intestinal function. The secondary outcome variables will consist of the severity of postoperative pain at 4, 12, 24 and 48 hours after surgery, the incidence of postoperative nausea and vomiting, and the length of hospital stay. A meta-analysis will be performed using RevMan V.5.4 software provided by the Cochrane Collaboration and Stata V.12.0. subgroup and sensitivity analyses will be conducted.Ethics and disseminationBecause the data used for this systematic review will be exclusively extracted from published studies, ethical approval and informed consent of patients will not be required. The systematic review will be published in a peer-reviewed journal, presented at conferences and shared on social media platforms.PROSPERO registration numberCRD42020216232.

A Escolha Dos Anestésicos Relacionado as Complicações Pós Operatórias De Cirurgias Abdominais

“…Apesar dos avanços recentes na administração da dor, muitos pacientes ainda experimentam níveis significativos de dor após a cirurgia. A administração de lidocaína intravenosa durante e após a cirurgia, como parte de uma abordagem multimodal, tem sido utilizada para alcançar a analgesia pós-operatória devido a sua capacidade de reduzir de forma significativa a dor aguda e crônica pós operatória, além de acelerar a recuperação do paciente (Ji et al, 2021). A infusão desse anestésico possui mecanismos multifatoriais, que incluem redução da sensibilidade da medula espinhal, bloqueio do canal de sódio e propriedades antiinflamatórias sistêmicas intrínsecas (Peng et al 2021).…”

Anesthesia and cancer recurrence: a narrative review

“…There are numerous suggested pathways responsible for the antitumor effects of lidocaine [86,[169][170][171][172][173][174]. However, clinical data are limited.…”