Effect of perioperative COX-2 and beta-adrenergic inhibition on 5-year disease-free-survival in colorectal cancer: A pilot randomized controlled Colorectal Metastasis PreventIon Trial (COMPIT)

Ricon‐Becker, Itay; Haldar, Rita; Simon, Maytal Shabat; Gutman, Mordechai; Cole, Steve W.; Ben‐Eliyahu, Shamgar; Zmora, Oded

doi:10.1016/j.ejso.2022.10.013

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“…COX-2 can have a role in tumor metastasis via epithelial-to-mesenchymal transition (EMT) (21). A recent pilot study aiming to evaluate the impact of perioperative combined COX-2 and beta-adrenergic blockade in colorectal cancer patients undergoing curative surgery revealed improvements in 5-year disease-free survival (22). In coherence with the above reports, our study also determined the upregulated expression level of COX-2 in colon tumors.…”

Section: Discussionsupporting

confidence: 60%