Effect of perioperative antioxidant therapy on suboptimal islet transplantation in rats

Brown, Melissa; Braun, M.; Cicalese, Luca; Rastellini, Cristiana

doi:10.1016/j.transproceed.2004.11.019

Cited by 9 publications

(7 citation statements)

References 2 publications

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“…The pyruvate protective effects above against diabetic glucometabolic aberrances, in vivo , as AR and PDK inhibition and PDH reactivation were replicated by pyruvate in HK-2 (human renal proximal tubular epithelial) cell lines in HG conditions, in vitro (data not shown), which also showed the inhibition of ER stress and cellular apoptosis of HK-2 cells by pyruvate addition in HG [ 39 ]. A recent investigation further demonstrated that diabetes markedly inhibited mitochondrial metabolism in pancreatic β -cells, whereas early studies displayed pyruvate preservation of islet engrafts function [ 40 , 41 ]. Present results that showed a consequence of rise in blood insulin levels are in consistence with these findings though islets were not investigated in the experiment.…”

Section: Discussionmentioning

confidence: 99%

Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic db/db Mice

Zhang

Deng

Jin

et al. 2020

Journal of Diabetes Research

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Diabetes is prevalent worldwide, but ideally intensive therapeutic strategy in clinical diabetes and diabetic nephropathy (DN) is still lack. Pyruvate is protective from glucometabolic disturbances and kidney dysfunction in various pathogenic insults. Present studies focused on oral pyruvate effects on diabetes status and DN with 0.35% pyruvate in pyruvate-enriched oral rehydration solution (Pyr-ORS) and 1% pyruvate as drinking water for 8 weeks, using the model of diabetic db/db mice. Both Pyr-ORS and 1% pyruvate showed comparable therapeutic effectiveness with controls of body weight and blood sugar, increases of blood insulin levels, and improvement of renal function and pathological changes. Aberrant key enzyme activities in glucometabolic pathways, AR, PK, and PDK/PDH, were also restored; indexes of oxidative stress and inflammation, NAD+/NADH ratio, and AGEs in the kidneys were mostly significantly preserved after pyruvate treatments. We concluded that oral pyruvate delayed DN progression in db/db mice and the modified Pyr-ORS formula might be an ideal novel therapeutic drink in clinical prevention and treatment of type 2 diabetes and DN.

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Section: Discussionmentioning

confidence: 99%

Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic db/db Mice

Zhang

Deng

Jin

et al. 2020

Journal of Diabetes Research

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“…Du et al showed in their experimental study the ability of vitamin C to inhibit inflammatory and pro-oxidative processes mediated by NF-κB [ 228 ]. Brown et al performed a similar study regarding the impact that vitamin E and vitamin C antioxidant therapy has on pancreatic transplantation and showed a significant decrease in the inflammatory and oxidative expressions [ 229 ]. Moon et al carried out a prospective, randomized study that included 132 patients scheduled for gynecological surgery.…”

Section: Perioperative Antioxidant Therapymentioning

confidence: 99%

The Impact of General Anesthesia on Redox Stability and Epigenetic Inflammation Pathways: Crosstalk on Perioperative Antioxidant Therapy

Ritiu

Rogobete

Săndesc

et al. 2022

Cells

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Worldwide, the prevalence of surgery under general anesthesia has significantly increased, both because of modern anesthetic and pain-control techniques and because of better diagnosis and the increased complexity of surgical techniques. Apart from developing new concepts in the surgical field, researchers and clinicians are now working on minimizing the impact of surgical trauma and offering minimal invasive procedures due to the recent discoveries in the field of cellular and molecular mechanisms that have revealed a systemic inflammatory and pro-oxidative impact not only in the perioperative period but also in the long term, contributing to more difficult recovery, increased morbidity and mortality, and a negative financial impact. Detailed molecular and cellular analysis has shown an overproduction of inflammatory and pro-oxidative species, responsible for augmenting the systemic inflammatory status and making postoperative recovery more difficult. Moreover, there are a series of changes in certain epigenetic structures, the most important being the microRNAs. This review describes the most important molecular and cellular mechanisms that impact the surgical patient undergoing general anesthesia, and it presents a series of antioxidant therapies that can reduce systemic inflammation.

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“…In 1990s, it was first found that pyruvate prolonged human pancreatic islets viability and protected from diabetic cataract both in, in vitro, experiments [23,24]. Subsequent studies not only indicated that pyruvate is an effective therapy in islet transplantation in diabetic rats, but also substantiated that oral pyruvate attenuates diabetic cataract after onset of cataract in, in vivo, investigations [21,25]. These findings were duplicated and further studies displayed that oral pyruvate effectively protected from diabetic retinopathy in rats [26,27].…”

Section: Evidence and Possibility Of Pyruvate Effects On Diabetesmentioning

confidence: 99%

Pyruvate May be a Novel Intervention of Diabetes

Zhou

2021

IOD

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Recent advances in pyruvate studies indicate that pyruvate may be a novel therapy in care of diabetes and its organ complications. The major action of pyruvate protection against diabetes may be in rejuvenation of glucose oxidation by preserving glycolysis and reactivating pyruvate dehydrogenase activity in the tricarboxylic acid cycle, reversing the Warburg effect in diabetic glucometabolic disorders. Pyruvate preservation of glucose metabolism plus its beneficial effects, such as anti-hypoxia, -oxidative stress, -acidosis, -apoptosis and -advanced glycation end products and stimulation of insulin secretion, may turn diabetic vicious circle virtuous in initiation and development of diabetic process. This review proposed a novel opinion focused on pyruvate superior biomedical and pharmacological properties in diabetes treatment and experimental and clinical evidence of pyruvate intervention in diabetes. The novel pyruvate modified oral rehydration salt (Pyr-ORS), based on WHO-ORS, may be helpful in the prevention and treatment of diabetes in a large population. Further studies and clinical trials are urgently required.

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Effect of perioperative antioxidant therapy on suboptimal islet transplantation in rats

Cited by 9 publications

References 2 publications

Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic db/db Mice

Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic db/db Mice

The Impact of General Anesthesia on Redox Stability and Epigenetic Inflammation Pathways: Crosstalk on Perioperative Antioxidant Therapy

Pyruvate May be a Novel Intervention of Diabetes

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