Effect of Perioperative Administration of Dexmedetomidine on Delirium After Cardiac Surgery in Elderly Patients: a Double-Blinded, Multi-Center, Randomized Study [Retraction]

Abstract

At the request of the authors, the Editor and Publisher of Clinical Interventions in Aging wish to retract the published article. Following publication, concerns were raised that the reported study did not match with details of the associated study that had been registered in the Chinese Clinical Trial Registry under registration number, ChiCTR-IOR-17014122.The authors responded to our queries and explained that they failed to complete registration of the study to the Chinese Clinical Trial Registry before starting their clinical research. Their request to retrospectively register the study prior to publication was declined by the Chinese Clinical Trial Registry because the trial had already been completed for three years. To comply with journal requirements the authors provided the clinical registration number (ChiCTR-IOR -17014122) from an unrelated dexmedetomidine study by members of their own research group. The owners of the study associated with registration number, ChiCTR-IOR-17014122, were unaware this number had been used in the publication of another study.The authors contacted the journal to request that the article be retracted and put this error in judgement down to inexperience and wish to apologise for any confusion that was caused.Our decision-making was informed by our policy on publishing ethics and integrity and the COPE guidelines on retraction.The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as "Retracted".

Influence of perioperative dexmedetomidine on the incidence of postoperative delirium in adult patients undergoing cardiac surgery

“…Thirteen studies used an initial bolus dose of dexmedetomidine of 0.4e1.5 mg kg À1 , 20,24,30e35,37,41,43,46,48 whereas the remainder only administered the drug as a continuous infusion. Ten trials measured postoperative delirium as their primary outcome, 11,12,24,36,37,41,42,44,46,48 and the most frequently utilised delirium assessment tool was the Confusion Assessment Method for Intensive Care Unit (CAM-ICU). 11e13,22e24,41,42,44,46,48 The findings of the risk of bias assessment can be seen in Figure 2.…”

Effect of Dexmedetomidine on Tachyarrhythmias After Cardiac Surgery: A Systematic Review and Meta-Analysis

“…Two hundred ten studies remained after reading the title and abstract. Ten studies did not have full text, resulting in 18 [11][12][13][14][15][16][17][18][19][21][22][23][24][25][26][27][28][29] articles that were finally included in the meta-analysis after a full-text screening of the remaining articles (Fig. 1).…”

“…The surgical types of 8 studies were simple CABG, 13,[15][16][17]19,21,22,24 2 studies were on simple valve surgery, 12,26 while the remaining studies were on adult cardiac surgery of all types. 11,18,23,25,[27][28][29] The included articles' baseline characteristics are shown in Table 1. The ROB tool of the Cochrane library was adopted to identify the risk of bias (Figs.…”

“…Previous retrospective studies 9,10 found that DEX can reduce the occurrence of AF after a heart surgery, which was also confirmed by randomized controlled trials (RCTs). [11][12][13][14] Yet, other studies [15][16][17][18][19] reported that DEX had no influence on AF incidence after a heart surgery. Besides, a meta-analysis 20 suggested that DEX may increase the incidence of AF after a heart surgery in patients with a history of AF.…”

Protocolo ERAS en cirugía cardiaca electiva: una revisión teórico práctica

“…En relación con el uso de la dexmedetomidina la investigación realizada por Shi et al 34 en la que estudiaron 164 pacientes se identificó que para pacientes de edad avanzada, la administración perioperatoria de dexmedetomidina (0.4-0.6 mg/kg/h) redujo la incidencia, aparición tardía y duración reducida del delirio posoperatorio 21 de 80 (26.3%) después de la cirugía cardíaca con respecto al propofol (1.5-2 mg/ kg) 33 de 84 pacientes(39,3%).…”