Effect of Periodontitis and Scaling and Root Planing on Risk of Pharyngeal Cancer: A Nested Case—Control Study

Abstract

This study investigated the association between periodontitis and the risk of pharyngeal cancer in Taiwan. For this population-based nested case–control study using the Longitudinal Health Insurance Database derived from Taiwan’s National Health Insurance Research Database, we identified patients (n = 1292) who were newly diagnosed with pharyngeal cancer between 2005 and 2013 and exactly paired them with propensity score matched control subjects (n = 2584). Periodontitis and scaling and root planing (SRP) were identified before the index date. Pharyngeal cancer was subdivided into 3 subgroups on the basis of anatomic location: nasopharyngeal cancer, oropharyngeal cancer, and hypopharyngeal cancer. A multiple conditional logistic regression model was applied to analyze the adjusted odds ratio (aOR). Periodontitis was associated with an increased risk of pharyngeal cancer (aOR, 1.57; 95% confidence interval (CI), 1.17 to 2.10), especially oropharyngeal cancer (aOR, 2.22; 95% CI, 1.07 to 4.60). We found a decreased risk of pharyngeal cancer in patients who had undergone SRP (aOR, 0.77; 95% CI, 0.61 to 0.96). In conclusion, this study showed that periodontitis was associated with an increased risk of pharyngeal cancer and SRP exerted a protective effect against pharyngeal cancer. Our results suggest that treating periodontitis and performing SRP, which are modifiable factors in oral health, in clinical practice may provide an opportunity to decrease the disease burden of pharyngeal cancer in Taiwan.

Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies

“…Table 1 presents a comprehensive overview of the eligible studies, delineating key characteristics such as the country of origin, study design, sample size, case and control group sizes, types of cases, and outcome indicators. Specifically, the analysis encompasses 12,584 case-control studies on OC, including OC [33][34][35][36][37], oral squamous cell carcinoma (OSCC) [38][39][40][41][42][43], oral cavity and/or oropharyngeal cancer (OOSCC) [44][45][46], and pharyngeal cancer [47], and 19,273 healthy controls. Among the included studies, six were conducted in Asia region [35,36,39,40,47,48], five in European regions [38,[41][42][43]46], two in the United States of America (USA) [37,45], and three in other countries [33,44,49].…”

Evaluation of Trans-Resveratrol as a Treatment for Periodontitis

“…Further to this, chronic PD has been linked to a range of malignancies [26][27][28][29][30] and respiratory diseases [31][32][33][34] (Figure 2). Accordingly, the necessity for more ways to effectively prevent, manage, and treat PD, remains paramount.…”

“…Morphometric analysis [27,100,101,103,[109][110][111] and/or Micro-CT [104,[112][113][114] has been employed to demonstrate that RES reduced the alveolar bone loss from experimentally induced PD. The micro-CT analyses also reported improved bone density, suggesting that at the very least, RES has therapeutic potential as an adjunct to traditional SRP.…”

Post-Therapy Sense of Taste Disorders in Nasopharyngeal Carcinoma

“…Consideration of the choice of radiation as the treatment of choice for NPC is mainly based on the fact that histopathologically most (75%-95%) NPC of undifferentiated carcinoma (WHO type 3) and non-keratinizing carcinoma (WHO type 2) are highly radiosensitive (Peng et al, 2019). Another reason is that the anatomical factor of the nasopharynx which is located at the base of the skull with many vital organs makes extensive surgery to obtain a tumor-free area (free margin) very difficult (Chen et al, 2021) (Chen et al, 2021). External radiation (teletherapy) at the loco-regional stage of NPC should be given at a sufficiently high dose (about 7000 cGy), aimed at the primary tumor in the nasopharynx and the area of expansion and metastasis in the cervical lymph nodes.…”