Effect of periodontal treatment in pregnancy on perinatal outcomes: a systematic review and meta-analysis

Bi, Wei Guang; Emami, Elham; Luo, Zhongming; Santamaria, Christina; Wei, Shu Qin

doi:10.1080/14767058.2019.1678142

Cited by 29 publications

(54 citation statements)

References 36 publications

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“…56 Daalderop et al 90 Findings from systematic reviews/meta-analyses of randomized clinical trials are mixed. Some reviews concluded that treatment of periodontal disease improved low birth weight outcomes, 1,76,77,82,83 while others failed to show such improvements. 75,78,79,81,85,[87][88][89]…”

Section: Extremely Low Birth Weight (Birth Weight < 1000 G)mentioning

confidence: 99%

Periodontology and pregnancy: An overview of biomedical and epidemiological evidence

Raju

Berens

2021

Periodontology 2000

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Women are particularly susceptible to developing gingival problems during pregnancy. In addition, periodontal disease in pregnant women may lead to adverse outcomes for both mother and infant, which have serious clinical and public health implications. Both scenarios have been extensively researched, helping to bring attention to pregnant women as an important and vulnerable population as it concerns periodontal health. The increase in gingival inflammation caused by hormonal changes in pregnant women is undisputed and has been studied and documented since the 1960s, although the exact etiology is not fully understood. The relationship between periodontal disease during pregnancy and adverse pregnancy outcomes is less substantiated, because of conflicting evidence. This review of the biomedical and epidemiologic literature provides an overview of both sides of this relationship and examines the potential mechanisms for developing periodontal disease during pregnancy and the proposed mechanisms by which periodontal disease leads to adverse pregnancy outcomes.

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Section: Extremely Low Birth Weight (Birth Weight < 1000 G)mentioning

confidence: 99%

Periodontology and pregnancy: An overview of biomedical and epidemiological evidence

Raju

Berens

2021

Periodontology 2000

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“…During pregnancy, due to hormonal factors (high oestrogen and progesterone), women are more vulnerable to periodontal disease than their non-pregnant peers [5]. Pregnant women with periodontal disease are more susceptible to poor maternal and perinatal outcomes such as preeclampsia [6], gestational diabetes [7], vulvovaginitis, preterm labour, foetal growth restriction [8], low birth weight [9] and perinatal mortality [10].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of and risk factors for periodontal disease among pregnant women in an antenatal care clinic in Khartoum, Sudan

et al. 2020

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Objectives: The aim was to investigate the prevalence of and factors associated with periodontal disease among pregnant Sudanese women. A cross-sectional study was conducted at the Antenatal Care Clinic of Saad Abualila Hospital (Khartoum, Sudan) from August to October 2018. Socioeconomic-demographic information and reproductive history were gathered using a questionnaire. Body mass index was computed from the weight and height. The diagnosis of periodontal disease was performed using criterion that also evaluated bleeding upon probing. Results: Four hundred and four women were enrolled in the study, with a mean (SD) gestational age of 30.0 (8.7) weeks. Their mean (SD) age and parity were 27.0 (5.7) years and 1.6 (1.7), respectively. Ninety-seven (24.0%) of these 404 women had periodontal disease, which was mild, moderate and severe in 49 (12.1%), 36 (8.9%) and 12 (3.0%) women respectively, while 307 (76.0%) women had no periodontal disease. In logistic regression, age, parity, education, and brushing were not associated with periodontitis, but lower gestational age was associated with periodontal disease (OR = 0.96, 95% CI 0.94-0.99, P = 0.011).

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“…Fortunately, periodontitis is a treatable and preventable disease and screening for this condition during pregnancy should not be overlooked by health care professionals. However, previous systematic reviews on the effect of periodontal treatment during pregnancy on maternal inflammatory and metabolic profile and gestational outcomes yielded inconsistent results [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…Although periodontal therapy improved maternal periodontal clinical parameters, no significant reduction in the levels of inflammatory markers in cord blood samples was detected [11]. Another systematic review including twenty RCTs investigated the effect of any type of periodontal treatment during pregnancy on perinatal mortality and found a significantly decreased risk of perinatal mortality among those in the treatment group [10]. The review also found a reduction in preterm birth and an increase in birthweight.…”

Section: Introductionmentioning

confidence: 99%

“…The review also found a reduction in preterm birth and an increase in birthweight. However, periodontal treatment did not reduce the risk of preeclampsia, gestational diabetes, cesarean section, small for gestational age, or congenital malformations [10]. Finally, a recent systematic review, including 19 RCTs on non-surgical periodontal treatment during pregnancy [12], concluded that this type of therapy is safe during pregnancy, and even though it does not entirely prevent adverse pregnancy outcomes, it can be safely recommended as a part of routine prenatal care.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Exploratory Efficacy of Calcium-Vitamin D Milk Fortification and Periodontal Therapy on Maternal Oral Health and Metabolic and Inflammatory Profile

et al. 2021

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In this 2 × 2 factorial, outcome-assessor blinded, feasibility randomised trial we explored the effect of a non-pharmaceutical multi-component intervention on periodontal health and metabolic and inflammatory profiles among pregnant women with periodontitis receiving prenatal care in a Brazilian public health centre. 69 pregnant women (gestational age ≤20 weeks, T0) were randomly allocated into four groups: (1) fortified sachet (vitamin D and calcium) and powdered milk plus periodontal therapy during pregnancy (early PT) (n = 17); (2) placebo sachet and powdered milk plus early PT (n = 15); (3) fortified sachet and powdered milk plus late PT (after delivery) (n = 19); (4) placebo sachet and powdered milk plus late PT (n = 18). Third trimester (T1) and 6–8 weeks postpartum (T2) exploratory outcomes included periodontal health (% sites with bleeding on probing (BOP)), glucose, insulin, C-Reactive Protein, serum calcium and vitamin D. The mean BOP was significantly reduced in the early PT groups, while BOP worsened in the late PT groups. No significant effect of fortification on BOP was observed. Changes in glucose levels and variation on birthweight did not differ among groups This feasibility trial provides preliminary evidence for estimating the minimum clinically important differences for selected maternal outcomes. A large-scale trial to evaluate the interventions’ clinical benefits and cost-effectiveness is warranted.

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Effect of periodontal treatment in pregnancy on perinatal outcomes: a systematic review and meta-analysis

Cited by 29 publications

References 36 publications

Periodontology and pregnancy: An overview of biomedical and epidemiological evidence

Periodontology and pregnancy: An overview of biomedical and epidemiological evidence

Prevalence of and risk factors for periodontal disease among pregnant women in an antenatal care clinic in Khartoum, Sudan

Exploratory Efficacy of Calcium-Vitamin D Milk Fortification and Periodontal Therapy on Maternal Oral Health and Metabolic and Inflammatory Profile

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