Effect of perfluorooctane sulfonate on toxicity and cell uptake of other compounds with different hydrophobicity in green alga

Acute and chronic toxicity of emerging contaminants, alone or in combination, in Chlorella vulgaris and Daphnia magna

“…In this case, no effects of any of the exposed pollutants were observed on toxicity, unlike the effects that PFOS provoked on the toxicity of different compounds in the study of Liu et al (2009). However in this case, the effects noted for the uptake or growth inhibition of different pollutants were observed at higher concentrations of PFOS (up to 40 mg/l) compared with our study, where the maximum concentration used was 1 mg/l.…”

“…Our results corroborated previous theories which considered that PFOS, with surfactant properties, could modify membrane cellular properties by increasing the bioavility of pollutants with high lipophilicity. Hu et al (2003) showed that the toxicity of tetrachlorodibenzo-p-dioxin and estradiol caused by PFOS increased; Liu et al (2008) demonstrated an increase in algal cell permeability, and they later suggested that PFOS could affect algal cell uptake and toxicity of various compounds differently (Liu et al 2009). Rodea-Palomares et al (2012) showed similar results for cyanobacterium bioluminescent toxicity test; in this case, PFOS displayed synergistic interactions with the organic compounds 2,4-D, furazolidone and mitomycin C. The authors explained this fact by means of the potential role of PFOS which enhanced the accessibility and cell uptake of co-existing hydrophobic compounds (RodeaPalomares et al 2012).…”

“…The coexistence of different emerging contaminants in the aquatic compartment has demonstrated interactions between compounds that could influence both uptake and toxicity. By way of example, Liu et al (2009) studied the interaction between PFOS and pentachlorophenol, atrazine and diuron on the growth of Scenedesmus obliquus. Their results demonstrated that PFOS can affect the cell uptake and toxicity of these compounds differently by increasing or reducing the toxicity of these compounds according to their hydrophobicity.…”

Enhanced cytotoxicity of pentachlorophenol by perfluorooctane sulfonate or perfluorooctanoic acid in HepG2 cells

“…PFOS might have considerable impact on the availability of cyclophosphamide to V79 cells, leading to the enhanced genotoxic action of cyclophosphamide (Jernbro et al, 2007). PFOS also increased the uptake of PCP in green alga, resulting in synergistic effect with PCP (Liu et al, 2009b). The synergistic effect of co-exposure to PFOS and another chlorinated phenol 2,4,6-trichlorophenol was also observed in green alga (Boltes et al, 2012).…”

Effect of PFOA/PFOS pre-exposure on the toxicity of the herbicides 2,4-D, Atrazine, Diuron and Paraquat to a model aquatic photosynthetic microorganism

“…Spent surfactants, after reaching biological treatment units, eventually are discharged to the environment, and PFCs will co-occur with other xenobiotics (Loos et al, 2007(Loos et al, , 2010. Several studies have dealt with co-exposure of PFCs with other contaminants, and different patterns of interactions have been found depending on the tested organism and the degree of hydrophobicity of both the PFC and tested pollutants (Hu et al, 2003;Liu et al, 2009;Watanabe et al, 2009;Rodea-Palomares et al, 2012b;Chen et al, 2013). PFCs co-exposure may potentially change the bioavailability, uptake and toxicology of co-existing xenobiotics (Hu et al, 2003;Liu et al, 2009;Chen et al, 2013).…”