Effect of percutaneous nucleoplasty with coblation on phospholipase A2 activity in the intervertebral disks of an animal model of intervertebral disk degeneration: a randomized controlled trial

Ren, Dajiang; Zhi-cheng, Zhang; Sun, Tiansheng; Li, Fang

doi:10.1186/s13018-015-0175-y

Cited by 14 publications

(13 citation statements)

References 15 publications

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“…PLA2 enzymes catalyze the hydrolysis of glycerophospholipids in the cellular membrane to produce free fatty acids, such as arachidonic acid (AA), which are used through the COX pathway to produce prostaglandins and other inflammatory mediators (Chacur et al, 2004; Svensson et al, 2005). sPLA2 increases in many painful conditions including discogenic pain (Ren et al, 2015), spinal cord injury (Titsworth et al, 2009), and inflammatory pain (Svensson et al, 2005) and its direct application to normal nerve tissue induces behavioral sensitivity (i.e. pain) and immune cell activation in the spinal cord (Chacur et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Pre-treatment with Meloxicam Prevents the Spinal Inflammation and Oxidative Stress in DRG Neurons that Accompany Painful Cervical Radiculopathy

et al. 2018

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Painful neuropathic injuries are accompanied by robust inflammatory and oxidative stress responses that contribute to the development and maintenance of pain. After neural trauma the inflammatory enzyme cyclooxygenase-2 (COX-2) increases concurrent with pain onset. Although pre-treatment with the COX-2 inhibitor, meloxicam, before a painful nerve root compression prevents the development of pain, the pathophysiological mechanisms are unknown. This study evaluated if pre-treatment with meloxicam prior to painful root injury prevents pain by reducing spinal inflammation and peripheral oxidative stress. Glial activation and expression of the inflammatory mediator secreted phospholipase A (sPLA) in the spinal cord were assessed at day 7 using immunohistochemistry. The extent of oxidative damage was measured using the oxidative stress marker, 8-hydroxyguanosine (8-OHG) and localization of 8-OHG with neurons, microglia and astrocytes in the spinal cord and peripherally in the dorsal root ganglion (DRG) at day 7. In addition to reducing pain, meloxicam reduced both spinal microglial and astrocytic activation at day 7 after nerve root compression. Spinal sPLA was also reduced with meloxicam treatment, with decreased production in neurons, microglia and astrocytes. Oxidative damage following nerve root compression was found predominantly in neurons rather than glial cells. The expression of 8-OHG in DRG neurons at day 7 was reduced with meloxicam. These findings suggest that meloxicam may prevent the onset of pain following nerve root compression by suppressing inflammation and oxidative stress both centrally in the spinal cord and peripherally in the DRG.

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Section: Introductionmentioning

confidence: 99%

Pre-treatment with Meloxicam Prevents the Spinal Inflammation and Oxidative Stress in DRG Neurons that Accompany Painful Cervical Radiculopathy

et al. 2018

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“…PPDD shows its effect by down-regulating local inflammatory mediators, reducing disc size, and initiating the repair process. Ren et al [ 19 ] found that PPDD effectively degraded phospholipase A2 (PLA2) activity. PLA2 activity is closely associated with intervertebral disc degeneration, intervertebral disc herniation, radicular pain, and lumbar discogenic pain.…”

Section: Discussionmentioning

confidence: 99%

“…In two long-term follow-up studies conducted in China, PPDD was shown to be effective for pain relief and function improvement for 2–3 years. However, there is no significant difference between the 3- and 5-year postoperative VAS and ODI scores, and excellent or good patient satisfaction was 87.9% at 1 week, 72.4% at 1 year, 67.7% at 3 years, and 63.4% at 5 years [ 19 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

A New Role for Epidurography: A Simple Method for Assessing the Adequacy of Decompression during Percutaneous Plasma Disc Decompression

Gil

wonseok

Choi

et al. 2022

JCM

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Percutaneous plasma disc decompression (PPDD) is a minimally invasive treatment for discogenic low back pain and herniated disc-related symptoms. However, there are no known outcome predictive variables during the procedure. The purpose of this study was to evaluate and validate epidurography as an intra-procedure outcome predictor. We retrospectively enrolled 60 consecutive patients who did not respond to conventional treatments. In the next stage of treatment, PPDD was performed, and the epidurography was conducted before and after the PPDD. We analyzed the relationship between epidurographic improvement and the success rate. The Numerical Rating Scale and the Oswestry Disability Index were used to assess pain and functional capacity, respectively, before the procedure and 1 month after the procedure. The pain reduction and the success rate in the epidurographic improvement group were significantly higher than in the epidurographic non-improvement group. Both the Numerical Rating Scale and the Oswestry Disability Index scores were significantly reduced in both groups, but there was no significant difference in Oswestry Disability Index scores. This study’s results showed that PPDD is an effective treatment method. We also suggested that epidurography may be a potential outcome predictor for ensuring successful outcomes and determining the endpoint of the procedure.

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“…These hydrolysis products are well-known mediators of inflammation and tissue damage; , specifically, the hydrolyzed free fatty acids are used in the cyclooxygenase pathways to produce prostaglandins and other inflammatory molecules . Additionally, increased sPLA 2 expression has been reported in many different persistent pain states that are characterized by inflammation, including intervertebral disc degeneration and spinal cord injury . After a peripheral neuropathic injury such as constriction of the sciatic nerve, sPLA 2 expression increases in both the DRG and the spinal cord .…”

Section: Therapeutic Targets and Materials For Painmentioning

confidence: 99%

Techniques for Multiscale Neuronal Regulation via Therapeutic Materials and Drug Design

Zhang

Kartha

Lee

et al. 2017

ACS Biomater. Sci. Eng.

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Neurotrauma is a common source for a host of neurological disorders, including chronic pain. Pathological changes underlying neural injury and pain are complex due to the multiscale spatiotemporal nature of the nervous system and its response to insults. Understanding the combined influence of tissue mechanics, neuronal and glial activation, and molecular processes on the development and maintenance of pain has recently gained attention. The growing knowledge about nociceptive mechanisms has inspired the design of novel therapeutic materials and compounds for neuronal regulation. Primary mechanical insults and secondary inflammatory responses can induce morphological changes, electrophysiological abnormalities, and altered neurotransmitter release associated with neuronal dysfunction, degeneration, and/or death in both central and peripheral nervous systems. Such responses in afferent and spinal dorsal horn neurons directly and indirectly potentiate pain. Using separate radiculopathy and joint pain models, the mechanical, nociceptive, and inflammatory aspects of pain are reviewed. In that context, biomaterials and compounds with material advantages, neuroprotective benefits, or anti-inflammatory effects to mitigate pain are identified. Several promising techniques to promote neuronal survival and axonal regeneration after injury, including bioactive scaffolds, blocking growthinhibitory molecules, and active drug delivery, are highlighted. Similar biomaterials-based strategies and molecular intervention have shown promise in attenuating various types of pain. Advancing these and other approaches will help advance and deepen the mechanistic understanding underlying trauma-induced pain across different length scales.

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Effect of percutaneous nucleoplasty with coblation on phospholipase A2 activity in the intervertebral disks of an animal model of intervertebral disk degeneration: a randomized controlled trial

Cited by 14 publications

References 15 publications

Pre-treatment with Meloxicam Prevents the Spinal Inflammation and Oxidative Stress in DRG Neurons that Accompany Painful Cervical Radiculopathy

Pre-treatment with Meloxicam Prevents the Spinal Inflammation and Oxidative Stress in DRG Neurons that Accompany Painful Cervical Radiculopathy

A New Role for Epidurography: A Simple Method for Assessing the Adequacy of Decompression during Percutaneous Plasma Disc Decompression

Techniques for Multiscale Neuronal Regulation via Therapeutic Materials and Drug Design

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