Effect of perchlorate and thiocyanate exposure on thyroid function of pregnant women from South-West England: a cohort study

Knight, Bridget; Shields, Beverley M.; He, Xuemei; Pearce, Elizabeth N.; Braverman, Lewis E.; Sturley, Rachel; Vaidya, Bijay

doi:10.1186/s13044-018-0053-x

Cited by 40 publications

(21 citation statements)

References 21 publications

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“…Although no direct correlation of perchlorate and these parameters was described, the increase in perchlorate, thiocyanate and urine nitrate concentrations was correlated with a slower waist and BMI increase. This contrasts with the results described above [124][125][126][127], where newborns were studied, but no dependence was found, or they were found only in boys or only for head circumference.…”

Section: Association Between Perchlorate Exposure and Children Gross contrasting

confidence: 99%

“…In addition, perchlorate and TSH were positively related. Also, Knight et al [124] confirms the critical negative correlation between urinary perchlorate concentration and serum FT 4 level. What is more, there was no correlation between the level of ClO 4 − and iodine in urine.…”

Section: Significant Associations Foundmentioning

confidence: 82%

“…In a study of Knight et al [124] in addition to the impact of perchlorate on the thyroid function, the birth weight of children was also measured and correlated with perchlorate level, but there was no significant correlation. The results are partly consistent with previous reports [125], where in a sample of 1,957 mother-child pairs, there are no significant relationships between perchlorate urine concentration and birth weight of children in the general population.…”

Section: Association Between Perchlorate Exposure and Children Gross mentioning

confidence: 99%

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Perchlorate – properties, toxicity and human health effects: an updated review

Niziński

Błażewicz

Kończyk

et al. 2020

Reviews on Environmental Health

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Interest in perchlorate as environmental pollutant has increased since 1997, when high concentrations have been found in the waters of the Colorado River, USA. Perchlorate is very persistent in nature and it is slowly degraded. Although harmful effects of large doses of perchlorate on thyroid function have been proven, the environmental effects are still unclear. The primary objective of the present review is to collect prevailing data of perchlorate exposure and to discuss its impact on human health. The results show that more than 50% of reviewed works found significant associations of perchlorate exposure and human health. This review consists of the following sections: general information of perchlorate sources, its properties and determination methods, role and sources in human body including food and water intake, overview of the scientific literature on the research on the effect of perchlorate on human health from 2010 to 2020. Finally, conclusions and recommendations on future perchlorate studies concerning human exposure are presented.

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Section: Association Between Perchlorate Exposure and Children Gross contrasting

confidence: 99%

Section: Significant Associations Foundmentioning

confidence: 82%

Section: Association Between Perchlorate Exposure and Children Gross mentioning

confidence: 99%

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Perchlorate – properties, toxicity and human health effects: an updated review

Niziński

Błażewicz

Kończyk

et al. 2020

Reviews on Environmental Health

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“…In a Mozambique rural population affected by spastic paraparesis, the anti-thyroid effect of thiocyanate from cassava-derived cyanide exposure manifested as decrease in serum T4 but increase in serum T3, T3/T4 ratio and TSH [40] . Thiocyanate also inhibited sodium-iodide symporter, thus reducing the transport of iodine from circulation into thyroid follicular cells which will impair thyroid hormone synthesis [41] . In weaned mice, thiocyanate decreased thyroid T3, T4 and iodine contents but increased plasma TSH with corresponding hyperthrophy of the thyroid gland, all of which followed recovery after thiocyanate withdrawal [42] .…”

Section: Discussionmentioning

confidence: 99%

Melatonin and Vitamin C Attenuate Cassava Diet-Induced Alteration in Thyroid Function

Alagbonsi¹,

Maliki²,

Ibitoye³

et al. 2020

Preprint

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Background Cyanide is present in cassava and is well known to cause adverse effects on the male reproductive functions. This study evaluated the effect of melatonin and/or vitamin C on body weight, thyroid function and reproductive parameters in male Wistar rats treated with cyanide-enriched cassava-diet (CD), and their possible mechanisms of actions. Methods Forty-five (45) animals were divided into 9 groups (n = 5 each) that received the following treatments for 28 days. Groups I-III received normal saline (control), melatonin (15 mg/kg), and vitamin C (100 mg/kg) only. Groups IV-VI received 40% CD, while groups V and VI were additionally treated with melatonin only and melatonin and vitamin C respectively. Groups VII-IX received 80% CD, but groups VIII and IX were additionally treated with melatonin only and melatonin and vitamin C respectively. Results Melatonin and/or vitamin C supplement increased body weight in CD-treated rats. The sperm count (but not other semen parameters) was increased by CD and melatonin, while combination of melatonin and vitamin C in CD-treated rats increased all semen parameters. Neither CD alone nor its co-administration with melatonin and /or vitamin C affected plasma luteinising hormone (LH) and testosterone. The 40% CD and 80% CD increased triiodothyronine (T3), but the increase by the former was abolished by melatonin alone while the increase by the latter was neither affected by melatonin alone nor its combination with vitamin C. Moreover, the 40% CD and 80% CD increased thyroxine (T4), but was neither affected by melatonin alone or its combination with vitamin C. The levels of thyroid stimulating hormone (TSH) were not different across all treatment groups. Both 40% CD and 80% CD increased the thiocyanate level, which was ameliorated by melatonin but abolished by combination of melatonin and vitamin C. Both 40% CD and 80% CD decreased the total antioxidant capacity (TAC) level, which was abolished by melatonin. Conclusion In conclusion, this study suggests that CD increases weight gain, thyroid hormone and oxidative stress, which were attenuated by anti-oxidants melatonin and vitamin C.

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“…In circulation FT4 perchlorate exposure is negatively associated with circulating levels in third trimester pregnant women. They used Perchlorate , Iodine, Pregnancy, birth and Weight [14].…”

Section: Related Workmentioning

confidence: 99%

Decision Tree Ensemble Techniques To Predict Thyroid Disease

Yadav*¹,

Pal²

2019

IJRTE

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Decision tree provides help in making decision for very complex and large dataset. Decision tree techniques are used for gathering knowledge. Classification tree algorithms predict the experimental values of women thyroid dataset. The objective of this research paper observation is to determine hyperthyroidism, hypothyroidism and euthyroidism participation in hormones can be good predictor of the final result of laboratories and to examination whether the propose ensemble approach can be similar accuracy to other single classification algorithm. In the proposed experiment real data from 499 thyroid patients were used classifications algorithms in predicting whether thyroid detected or not detected on the basis of T3, T4 and TSH experimental values. The results show that the expectation of maximization classification tree algorithms in those of the best classification algorithm especially when using only a group of selected attributes. Finally we predict batch size, tree confidential factor, min number of observation, num folds, seed, accuracy and time build model with different classes of thyroid sickness. Different classification algorithms are analyzed using thyroid dataset. The results obtained by individual classification algorithms like J48, Random Tree and Hoeffding gives accuracy 99.12%, 97.59% and 92.37 respectively. Then we developed a new ensemble method and apply again on the same dataset, which gives a better accuracy of 99.2% and sensitivity of 99.36%. This new proposed ensemble method can be used for better classification of thyroid patients.

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Effect of perchlorate and thiocyanate exposure on thyroid function of pregnant women from South-West England: a cohort study

Cited by 40 publications

References 21 publications

Perchlorate – properties, toxicity and human health effects: an updated review

Perchlorate – properties, toxicity and human health effects: an updated review

Melatonin and Vitamin C Attenuate Cassava Diet-Induced Alteration in Thyroid Function

Decision Tree Ensemble Techniques To Predict Thyroid Disease

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