Effect of Peony‐Glycyrrhiza Decoction on Amisulpride‐Induced Hyperprolactinemia in Women with Schizophrenia: A Preliminary Study

Abstract

Objective The aim of this study is to observe the effect of Peony-Glycyrrhiza Decoction (PGD) on hyperprolactinemia in women with schizophrenia induced by Amisulpride. Material and Methods A total of 41 female schizophrenia patients receiving Amisulpride were randomly divided into placebo (n = 20) and PGD groups (n = 21). Maintaining the original Amisulpride dose, the two groups were given placebo and PGD, respectively. The levels of Prolactin (PRL) and other hormones were measured on the initial day and at weeks 4 and 8 after treatment. Changes of clinical symptoms in patients with hyperprolactinemia were observed. The PANSS scores were recorded to assess the psychotic symptoms. Results Compared with placebo group, level of PRL decreased while Progesterone increased remarkably in the PGD group at weeks 4 and 8 (p < 0.01), and level of Estradiol in the PGD group increased significantly at week 8 (p < 0.05). There were no differences in PANSS scores and biochemical indexes between two groups at weeks 4 and 8. Conclusion PGD can improve symptoms of hyperprolactinemia and hormone levels in women with schizophrenia caused by Amisulpride, without affecting their mental symptoms and biochemical indexes.

Amisulpride steady-state plasma concentration and adverse reactions in patients with schizophrenia: a study based on therapeutic drug monitoring data

“…As previously reported by Yang et al (2017), the anterior pituitary D 2 receptor can be blocked by amisulpride, subsequently diminishing the inhibitory effect of dopamine secretion, and inducing an increase in PRL. The findings of that study are consistent with those of the present study.…”

“…Thus, the level of PRL in patients treated with amisulpride should be closely monitored. Studies have demonstrated that intervention with Chinese herbs, such as Peony-Glycyrrhiza Decoction (Yang et al , 2017), etc., can improve the symptoms of hyperprolactinemia and reduce PRL levels induced by amisulpride, without influencing mental symptoms and other biochemical indexes.…”

Adjunctive Peony-Glycyrrhiza decoction for antipsychotic-induced hyperprolactinaemia: a meta-analysis of randomised controlled trials

“…Only two RCTs24 25 reported hyperprolactinaemia-induced symptoms. In one RCT,25 79% of patients in the PGD group and 0% in the placebo group reported improvement in hyperprolactinaemia-induced adverse effects. In another RCT,24 68% of patients on PGD and 54% on placebo reported improvement in hyperprolactinaemia-induced adverse effects.…”

Metformin in the Treatment of Amisulpride-Induced Hyperprolactinemia: A Clinical Trial

“…( 4) Combine with some traditional Chinese medicine, such as Maiya, Sichuan Pepper, dandelions, Achyranthes Bidentata, Ziyin Rougan decoction, and Xiaoyao pills. However, the current studies lack high-level evidence because of their small samples (Yang et al, 2017). ( 5) Recent studies have shown that aripiprazole adjuvant therapy can reduce antipsychoticinduced HPRL with good tolerance (Raghuthaman et al, 2015;Jiang et al, 2018).…”