Effect of pentoxifylline on survival and intestinal cytokine messenger RNA transcription in a rat model of ongoing peritoneal sepsis

Jl, Nelson; Jw, Alexander; Jx, Mao; Vohs, T; Ck, Ogle

doi:10.1097/00003246-199901000-00038

Cited by 28 publications

(17 citation statements)

References 30 publications

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“…Nonetheless, studies also support other tissues (i.e., gut) as an important source of IL-6 after injury (8,23). In this regard, Nelson et al (21) showed that inhibition of gut-derived IL-6 with pentoxifylline improved survival after sepsis. Thus the beneficial effects of 17␤-estradiol after hypoxia may also be related to attenuation of the cytokine (IL-6) response of the gut.…”

Section: Discussionmentioning

confidence: 94%

Estrogen pretreatment protects males against hypoxia-induced immune depression

Knöferl

Schwacha

Jarrar

et al. 2002

American Journal of Physiology-Cell Physiology

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. Estrogen pretreatment protects males against hypoxia-induced immune depression. Am J Physiol Cell Physiol 282: C1087-C1092, 2002. First published December 12, 2001 10.1152/ajpcell.00454.2001.-Hypoxemia depresses cell-mediated immune functions in males, whereas proestrous females do not show such a depression. We hypothesized that elevated systemic estradiol levels in proestrous females prevent hypoxemia-induced immune depression. To study this hypothesis, male C3H/HeN mice were pretreated with 17␤-estradiol (E 2, 40 g/kg body wt sc) or vehicle for 3 days before induction of hypoxemia and again immediately before induction of hypoxia. The mice were subjected to hypoxemia (95% N 2-5% O2) or sham hypoxemia (room air) for 60 min, and plasma and spleen cells were collected 2 h later. In vehicle-treated mice, splenocyte proliferation and interleukin-2 and interleukin-3 production were depressed after hypoxemia. E 2-pretreated animals, however, displayed no such depression in splenic T cell parameters after hypoxemia. Splenic macrophage cytokine production was also depressed in vehicle-treated mice subjected to hypoxia, whereas it was normal in E 2-pretreated mice. In summary, these findings indicate that administration of E 2 before hypoxemia prevented the depression of cell-mediated immune functions. Thus administration of 17␤-estradiol in high-risk patients before major surgery might decrease hypoxemia-induced immune depression under those conditions.

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Section: Discussionmentioning

confidence: 94%

Estrogen pretreatment protects males against hypoxia-induced immune depression

Knöferl

Schwacha

Jarrar

et al. 2002

American Journal of Physiology-Cell Physiology

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“…at a dose of 5 mg/kg body weight in 200 l of phosphate-buffered saline (PBS) beginning on the day of DSS exposure. 7,8,18,19 Pilot studies examined the effect of a single daily injection of ROL at the same dose. Time-matched controls consisted of naïve mice, mice administered DSS, ROL, or PTX only, and those injected with ethanol (10 l in 190 l of PBS) only, the vehicle for ROL.…”

Section: Animals and Experimental Treatmentmentioning

confidence: 99%

Dextran Sulfate Sodium-Induced Colonic Histopathology, but not Altered Epithelial Ion Transport, Is Reduced by Inhibition of Phosphodiesterase Activity

Diaz-Granados¹,

Howe²,

Lü³

et al. 2000

The American Journal of Pathology

117

100

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Inhibition of phosphodiesterase (PDE) activity is beneficial in models of arthritis and airway inflammation.Here we assessed the ability of PDE inhibitors to modulate colitis by exposing mice to 4% (w/v) dextran sulfate sodium (DSS) drinking water for 5 days with or without rolipram, an inhibitor of PDE type 4, or the nonselective PDE inhibitor, pentoxifylline (both at 5 mg/kg, i.p., twice daily). Controls received saline, vehicle, or drug only. Colonic histology, myeloperoxidase (MPO) and tumor necrosis factor-␣ (TNF-␣) levels, and epithelial ion transport (baseline and stimulated by electrical nerve stimulation, carbachol, and forskolin) were examined. DSS-treated mice displayed a variable diarrhea, significant histopathology in the mid-distal colon, elevated MPO activity, and reduced (>50%) responses to all three pro-secretory stimuli. Treatment with rolipram, and to a lesser extent pentoxifylline, significantly reduced the severity of the colonic histopathology and MPO levels. Neither PDE inhibitor had any affect on the diminished ion transport events caused by DSS-induced colitis. However, although stimulated ion transport events were still reduced 3 days after DSS treatment, colonic segments from DSS ؉ rolipram-treated mice displayed enhanced recovery in their secretory responsiveness, particularly to carbachol. These findings indicate that specific PDE4 inhibition can significantly reduce the tissue damage that accompanies colitis and enhance recovery of normal colonic function.

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“…These results suggest that the protective effects of E 2 on lung injury following trauma-hemorrhage are mediated via downregulation of lung MIF and TLR4-induced cytokine/chemokine production. hemorrhagic shock; 17␤-estradiol; Toll-like receptor 4; myeloperoxidase; cytokines; chemokines DESPITE NUMEROUS ADVANCES in intensive care medicine, ischemia-reperfusion, sepsis, and organ dysfunction leading to multiple organ failure remain the major causes of death after trauma (1,20,23,31,32). Hemorrhagic shock is a major contributor to the development of acute respiratory distress syndrome (ARDS) in patients who sustain major mechanical trauma (30).…”

mentioning

confidence: 99%

Downregulation of migration inhibitory factor is critical for estrogen-mediated attenuation of lung tissue damage following trauma-hemorrhage

Hsieh

Frink

Hsieh

et al. 2007

American Journal of Physiology-Lung Cellular and Molecular Phys

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Effect of pentoxifylline on survival and intestinal cytokine messenger RNA transcription in a rat model of ongoing peritoneal sepsis

Abstract: Low-dose (but not high-dose) pentoxifylline administration reduced production of some, but not all, cytokines studied in the gut and liver in a rat model of acute peritonitis and this reduced production was associated with an improved survival in such animals.

Cited by 28 publications

References 30 publications

Estrogen pretreatment protects males against hypoxia-induced immune depression

Estrogen pretreatment protects males against hypoxia-induced immune depression

Dextran Sulfate Sodium-Induced Colonic Histopathology, but not Altered Epithelial Ion Transport, Is Reduced by Inhibition of Phosphodiesterase Activity

Downregulation of migration inhibitory factor is critical for estrogen-mediated attenuation of lung tissue damage following trauma-hemorrhage

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