Effect of pentobarbital on isometric contractions and parameters of active state in cat papillary muscle

Dresel, Peter E.; Ellett, Robert W.; Schluter, Lothar

doi:10.1016/0024-3205(70)90285-7

Cited by 6 publications

(2 citation statements)

References 3 publications

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“…An ino tropic agent administered to an animal under pentobarbital anesthesia might have differing effects (as observed with low doses of dopa mine in young piglets, in fig. 2), depending upon the degree of prior depression by pento barbital [11,14], We demonstrated pre viously that a low dose of isoproterenol in creased right ventricular dP/dtmax in day-old piglets anesthetized with pentobarbital, but that the inotropic response to norepinephrine required a relatively high dose at that age [ 10].…”

Section: Discussionmentioning

confidence: 94%

Cardiovascular Effects of Dopamine in Developing Swine

Buckley¹,

Brazeau²,

Frasier³

1983

Neonatology

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Cardiac function and peripheral blood flows were measured before and during single intravenous injections of dopamine (2–25 μg/kg) in developing and mature swine anesthetized with pentobarbital. A positive inotropic effect was observed in even the youngest swine. Renal vasoconstriction was observed even after low doses of dopamine in animals younger than 1 month of age, and femoral vasoconstriction in animals younger than 2 weeks of age, unless α-adrenergic receptors were blocked by phentolamine. We concluded that the vasodilator responses to dopamine are slower to develop in the renal than in the femoral circulation.

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Section: Discussionmentioning

confidence: 94%

Cardiovascular Effects of Dopamine in Developing Swine

Buckley¹,

Brazeau²,

Frasier³

1983

Neonatology

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“…The results of comparative study have been reported of volatile anesthetic agents by means of force-velocity relations in the isolated cat papillary heart muscle (Iwatsuki and Shimosato 1971), but there have been few reports of comparative study on the direct myocardial effect of intra venous anesthetic agents. In regard to barbiturates, a negative inotropic effect of pentobarbital has been well documented (Siegel and Sonnenblick 1964;Dresel et al 1970), but there have been few studies on thiamylal (Sawyer et al 1971). A direct depressive action of propanidid on the heart was suggested in the isolated guinea pig hearts and in men (Astrom et al 1970 Comparison of Thiamylal, Propanidid and CT 1341…”

mentioning

confidence: 99%