Effect of Pentagastrin and Cimetidine on Gastric Blood Flow Measured by Laser Doppler Flowmetry

Abstract

Endoscopic laser Doppler flowmetry has been used to study the effect of the secretagogue pentagastrin and the H2-receptor antagonist cimetidine on gastric blood flow in 24 healthy subjects. The subcutaneous injection of pentagastrin, 0.6 micrograms/kg body weight, caused a significant increase in gastric acid secretion. This increase did not provoke any significant change in gastric blood flow, measured in seven defined areas of the oesophagus and stomach. Furthermore, no significant correlation was found between the level of basal and maximal acid secretion and blood flow. The infusion of 200 mg cimetidine caused a significant reduction of gastric blood flow in five of the seven investigated areas (P less than 0.05 and P less than 0.01). Cimetidine had no effect on blood pressure or skin blood flow, measured by laser Doppler flowmetry. The study was performed without previous stimulation of acid secretion, and blood flow reduction was measured in both the corpus and the antrum of the stomach. The effect of cimetidine is therefore hardly a result of the acid-reducing effect of the drug. In this study no significant relationship could be shown between the gastric wall blood flow and acid secretion.

Laser doppler flowmetry for estimation of bone blood flow: Studies of reproducibility and correlation with microsphere technique

“…LDF provides continuous, real-time monitoring of changes in local microvascular perfusion, and the LDF output signal correlates well with other methods of measuring blood flow in various tissues (1,2,4,6,13,16,22,24,25). Accordingly, LDF has proven useful for measurement of blood flow changes in the cerebral cortex (6,24), gastrointestinal canal (12,18,21,23),myocardial and skeletal muscle (1,10,14),skin (3,11,26), and renal cortex (22). So far, only a few studies have reported on the feasibility of LDF in the study of the microvascular perfusion in bone (5,8, 9,28,29,32).…”

“…Accordingly, LDF has proven useful for measurement of blood flow changes in the cerebral cortex (6,24), gastrointestinal canal (12,18,21,23),myocardial and skeletal muscle (1,10,14),skin (3,11,26), and renal cortex (22). So far, only a few Received December 30,1991; accepted January 18,1993.…”

Effects of histamine H2‐receptor blockade on the cardiovascular reflex response to lower‐body negative pressure in man

“…There are relatively few data available concerning the effects of H,-receptor antagonists on blood flow in other vascular beds in humans. Cutaneous blood flow is not significantly affected by cimetidine (Knigge et al 1988), and cimetidine seems to decrease blood flow in the human pentagastrin-stimulated gastric mucosa (Ivarsson et al 1984, Lunde et al 1988). The effect of H,-receptor antagonists on ' resting ' human gastric blood flow is not known, but in anaesthetized rats neither ranitidine nor cimetidine has any consistent effects on basal gastric blood flow (hydrogen clearance technique) (Pique et al 1988).…”

Gastric Blood Flow and Acid Secretion: Problems of the Methodology and Regulatory Mechanisms

“…There are relatively few studies to answer this question, but in general, changes in MBF and HCl secretion were reported in human studies during pentagastrin stimulation (41,44,47,86,87) and during 'sham' feeding (45). There are relatively few studies to answer this question, but in general, changes in MBF and HCl secretion were reported in human studies during pentagastrin stimulation (41,44,47,86,87) and during 'sham' feeding (45).…”