Effect of PEGylation on the Drug Release Performance and Hemocompatibility of Photoresponsive Drug-Loading Platform

Abstract

Coronary stenosis has been one of the most common heart diseases that drastically increases the risk of fatal disorders such as heart attack. Angioplasty using drug coated balloons (DCB) has been one of the most safe and promising treatments. To minimize the risk of thrombosis of such DCBs during intervention, a different approach that can secure high hemocompatibility under blood flow is necessary. Here we report a method of improving the photoresponsive platform’s hemocompatibility by conjugating polyethylene glycol (PEG), onto the functional groups located at the balloon surface. In this study, latex microbeads were used as models for balloons to enable precise observation of its surface under microscopy. These beads were decorated with PEG polymers of a variety of lengths and grafting densities, along with the Cy5-Photoclevable (PC) linker conjugate to mimic drugs to be loaded onto the platform. Results showed that PEG length and grafting density are both critical factors that alter not only its hemocompatibility, but also the drug load and release efficiency of such platform. Thus, although further investigation is necessary to optimize the tradeoff between hemocompatibility, drug load, and release efficiency, it is safe to conclude that PEGylation of DCB surface is an effective method of enhancing and maintaining high hemocompatibility to minimize the risk of thrombosis during angioplasty.

Numerical Approaches for Recovering the Deformable Membrane Profile of Electrostatic Microdevices for Biomedical Applications

“…As known, microelectromechanical systems (MEMS) allow for the creation of both sensors and actuators capable of using non-electrical devices in microchips [ 1 , 2 ]. Fluidic devices such as micropumps were historically the first to be made and, with the discovery of new pharmacological therapies [ 3 , 4 , 5 , 6 ], today they represent a highly developed research area. Currently, microfluidics is based on sophisticated physical-mathematical models which, unlike macroscopic applications, are able to take into account electrokinetic [ 7 ], magnetohydrodynamic [ 8 ], electrochemical [ 9 ], electrostatic [ 1 ] and other effects [ 10 , 11 ].…”

Optimization and modeling of PEGylated, hydrocortisone‐17‐butryate‐loaded poly(lactic‐co‐glycolic acid) microspheres

“…However, the effects of PEGylation on corticosteroid release and overall characteristics of PLGA nanospheres has not been quantified and accurately computationally modeled. [15][16][17][18] Therefore it is proposed, through formulation optimization and modeling this corticosteroid delivery platform can extend therapeutic duration, alleviate high corticosteroid concentration effects, and be more effectively dosed through application of a biphasic release model for the PEGylated nanocarriers.…”