Effect of Pegylated Polypropylene Imine Dendritic Architecture on Pharmacokinetics of Pyrazinamide on Rabbits
ARUL BALASUBRAMANIAN,
VALLI MANALAN BALASUBRAMANIAN,
KOTHAI RAMALINGAM
Abstract:Objective: This study sought to investigate the impact of pegylated polypropylene imine dendrimer-loaded pyrazinamide on drug delivery and assess this novel formulation's pharmacokinetic parameters.
Methods: Various concentrations of pyrazinamide-loaded dendrimers were formulated in four distinct batches, with the most promising formulation selected for administration to New Zealand rabbits. Plasma concentrations of the drug were subsequently compared to those of the pure drug. Pharmacokinetic parameters, incl… Show more
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