Effect of peak expiratory flow rate measurement on exhaled nitric oxide levels in children with asthma

Nelson, Kyle A.; Lee, Pearlene; Yan, Yan; Hodgdon, Kevin; Schootman, Mario; Strunk, Robert C.

doi:10.1016/j.jaci.2006.08.026

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…1) is skewed towards the right with a median of 14.0 ppb (Q1,Q3: 10.5, 24.4). FeNO levels were measured with high intra-subject reproducibility, as evident by 86.5% of the children having at least two FeNO measurements within 5ppb or 10% of each other 19 . Median FeNO levels (Q1,Q3) did not differ between children who were recruited to the study in the spring (15.50 (11.17, 26.67) ppb; n=18), summer (13.03 (9.97, 21.40) ppb; n=51) or fall (17.40 (11.68, 33.48); n=20) (P=0.25).…”

Section: Resultsmentioning

confidence: 99%

Effect of elevated exhaled nitric oxide levels on the risk of respiratory tract illness in preschool-aged children with moderate-to-severe intermittent wheezing

Beigelman

Mauger

Phillips

et al. 2009

Annals of Allergy, Asthma & Immunology

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Background The fractional concentration of exhaled nitric oxide (FeNO) is a noninvasive marker for airway inflammation but requires further study in pre-school children to determine its clinical relevance. Objective To determine whether the risk of respiratory tract illnesses (RTI), disease burden and atopic features are related to FeNO in preschool children with moderate-to-severe intermittent wheezing. Methods We determined FeNO using the off-line tidal breathing technique in 89 children, 12–59 months old, with moderate-severe intermittent wheezing. Risk of RTI was determined by comparing participants with baseline FeNO >75th percentile (24.4ppb) to those with FeNO ≤75th percentile using Cox regression analysis. Results The risk of RTI was significantly higher in children with FeNO >24.4ppb relative to those with lower FeNO values (adjusted RR= 3.8, 95% CI: 1.74–8.22; p=0.0008). FeNO levels >24ppb were associated with a greater number of positive skin tests to aeroallergens (p=0.03), but not with other atopic characteristics or historic parameters of illness burden. Conclusion Elevated FeNO in preschool children with moderate-to-severe intermittent wheezing was associated with an increased risk of RTI during a one-year follow-up. In addition, higher FeNO was associated with aeroallergen sensitization.

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Section: Resultsmentioning

confidence: 99%

Effect of elevated exhaled nitric oxide levels on the risk of respiratory tract illness in preschool-aged children with moderate-to-severe intermittent wheezing

Beigelman

Mauger

Phillips

et al. 2009

Annals of Allergy, Asthma & Immunology

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Component-resolved evaluation of the content of major allergens in therapeutic extracts for specific immunotherapy of honeybee venom allergy

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Etzold

Darsow

et al. 2017

Human Vaccines & Immunotherapeutics

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Allergen-specific immunotherapy is the only curative treatment of honeybee venom (HBV) allergy, which is able to protect against further anaphylactic sting reactions. Recent analyses on a molecular level have demonstrated that HBV represents a complex allergen source that contains more relevant major allergens than formerly anticipated. Moreover, allergic patients show very diverse sensitization profiles with the different allergens. HBV-specific immunotherapy is conducted with HBV extracts which are derived from pure venom. The allergen content of these therapeutic extracts might differ due to natural variations of the source material or different down-stream processing strategies of the manufacturers. Since variations of the allergen content of therapeutic HBV extracts might be associated with therapeutic failure, we adressed the component-resolved allergen composition of different therapeutic grade HBV extracts which are approved for immunotherapy in numerous countries. The extracts were analyzed for their content of the major allergens Api m 1, Api m 2, Api m 3, Api m 5 and Api m 10. Using allergen-specific antibodies we were able to demonstrate the underrepresentation of relevant major allergens such as Api m 3, Api m 5 and Api m 10 in particular therapeutic extracts. Taken together, standardization of therapeutic extracts by determination of the total allergenic potency might imply the intrinsic pitfall of losing information about particular major allergens. Moreover, the variable allergen composition of different therapeutic HBV extracts might have an impact on therapy outcome and the clinical management of HBV-allergic patients with specific IgE to particular allergens.

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2007

Pediatric Asthma, Allergy & Immunology

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Effect of peak expiratory flow rate measurement on exhaled nitric oxide levels in children with asthma

Cited by 3 publications

References 7 publications

Effect of elevated exhaled nitric oxide levels on the risk of respiratory tract illness in preschool-aged children with moderate-to-severe intermittent wheezing

Effect of elevated exhaled nitric oxide levels on the risk of respiratory tract illness in preschool-aged children with moderate-to-severe intermittent wheezing

Component-resolved evaluation of the content of major allergens in therapeutic extracts for specific immunotherapy of honeybee venom allergy

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