Effect of paternal alcohol consumption before conception on infant birth weight

Passaro, Kristi Tolo; Little, Ruth E.; Savitz, David A.; Noss, John

doi:10.1002/(sici)1096-9926(199806)57:6<294::aid-tera2>3.0.co;2-x

Cited by 41 publications

(17 citation statements)

References 20 publications

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“…While some studies have shown that alcohol orally administered to male mice for periods of between 24 h and 3 months prior to conception tends to result in decreased birth weights of sired offspring (Cicero et al, 1994; Ledig et al, 1998); others have not observed such an effect in both humans and rodent models (Anderson and Willis, 1981; Abel and Lee, 1988; Abel and Tan, 1988; Abel, 1989, 1993; Passaro et al, 1998; Livy et al, 2004). Although these latter findings are supported by our study (when offspring are stratified by sex; data not shown), evidence of significant age-dependent growth restriction of both male and female offspring sired by ethanol-exposed males was observed, from approximately postnatal day 35–42.…”

Section: Discussionmentioning

confidence: 99%

“…One study reported that 75% of children with FAS had biological fathers who were heavy drinkers or alcoholics (Abel et al, 1983); and several rodent and human studies have reported that preconception paternal alcohol intake has been associated with congenital malformations, low birth weights, growth retardation, and neonatal mortality (Friedler, 1996; Passaro et al, 1998). These effects are not consistent between inbred rodent strains, suggesting a genetic contribution to the phenotype outcome.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Preconception Paternal Alcohol Exposure on Epigenetic Remodeling of the H19 and Rasgrf1 Imprinting Control Regions in Mouse Offspring

Knezovich¹,

Ramsay²

2012

Front. Gene.

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Imprinted loci play a critical role in fetal development. Their expression is often regulated by CCCTC-binding factor (CTCF) protein binding at imprinting control regions (ICRs). Prenatal alcohol exposure has been shown to reduce global DNA methylation in the developing mouse fetus. This study explored the effect of preconception paternal alcohol exposure on DNA methylation at two paternally methylated ICRs (H19 and Rasgrf1) in the sperm of exposed males and somatic DNA of sired offspring. Significant reductions at the H19 CTCF 1 (p = 0.0027) and CTCF 2 (p = 0.0009) binding sites were observed in the offspring of ethanol-treated sires, which was significantly correlated with reduced weight at postnatal days 35–42 (p < 0.05). As birth weight was unaffected and growth was only delayed during the postnatal weaning period, with subsequent re-convergence, we hypothesize that this may be the result of a mental deficit causing delayed establishment of independent feeding following weaning and would explain why this effect is transient. No difference in DNA methylation was observed in the sperm of alcohol-exposed males, indicating that the transmission of the epigenetic signal at conception is not due to altered methylation, but may be the result of an RNA-mediated mechanism or altered chromatin remodeling.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effect of Preconception Paternal Alcohol Exposure on Epigenetic Remodeling of the H19 and Rasgrf1 Imprinting Control Regions in Mouse Offspring

Knezovich¹,

Ramsay²

2012

Front. Gene.

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“…Partners' smoking habits have been one of the strongest predictors of prenatal cigarette use (Olsen, 1993;Waterson et al, 1990). Maternal drinking is highly correlated with paternal drinking (Passaro et al, 1998), because the premarriage alcohol consumption of husbands has been found to be unilaterally influential on their wives' drinking after marriage (Leonard and Das Eiden, 1999;Leonard and Mudar, 2003). Thus, educational efforts in India, Turkey, and Sweden have focused on including expectant fathers in antenatal education, resulting in positive effects on knowledge, attitudes, and behaviors (Finnbogadottir et al, 2003;Hallgren et al, 1999;Pachuri, 2001;Turan et al, 2001).…”

Section: Abstract Objectivementioning

confidence: 99%

Alcohol use by pregnant women: partners, knowledge, and other predictors.

et al. 2006

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ABSTRACT. Objective:The impact of a couple's knowledge about healthy pregnancy habits involving alcohol and substance use was assessed in the context of other factors previously identified to predict prenatal alcohol consumption in a sample of 254 pregnant women and their male partners. Method: Couples were asked to assess independently a series of statements (true or false) describing the consequences of prenatal substance exposure, while also providing information about their own drinking. Results: Although the couples demonstrated good knowledge of healthy habits during pregnancy, they did not agree when the element of chance was considered. Median household income was more highly predictive of a pregnant woman's knowledge score than her partner's score. In turn, the subject's knowledge of healthy pregnancy habits as manifested in the assessment score had only a weak relationship with prenatal alcohol consumption. Previous alcohol use by the pregnant woman was the strongest predictor of prenatal alcohol use. Conclusions: Because previous alcohol consumption use by the pregnant woman was the strongest predictor of prenatal alcohol use, the importance of its accurate identification is emphasized. Although pending further investigation, knowledge about healthy pregnancy behaviors may exert greater impact if it is shared by a pregnant woman and her partner. (J. Stud. Alcohol 67: [245][246][247][248][249][250][251] 2006)

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“…Contemporary population-based data on alcohol and tobacco use, collected in early pregnancy in another Australian state (Tasmania) did not show adverse effects of alcohol on fetal growth or preterm birth until maternal consumption was reported at more than two standard drinks a day [34], a level of drinking reported by 0.4% of Tasmanian women. Subsequent research in large cohorts has not confirmed the early US studies [35,36]. …”

Section: Discussionmentioning

confidence: 97%

Aiming to increase birth weight: a randomised trial of pre-pregnancy information, advice and counselling in inner-urban Melbourne

Lumley

Donohue

2006

BMC Public Health

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BackgroundIn the 1980s there was substantial interest in early pregnancy and pre-pregnancy interventions to increase birth weight and reduce preterm birth. We developed an inter-pregnancy intervention, implemented in a randomised controlled trial, to be provided by midwives at home soon after women's first birth.MethodsMCH nurses invited women to take part during their home visit to new mothers. Women's contact details, with their permission, were passed to the study midwife. She had a randomisation schedule to which women's names were added before she met the women or their partners. All women recruited had a home visit from the study midwife with a discussion of their first pregnancy, labour and birth and the postpartum experience. Women in the intervention arm received in addition a pre-pregnancy intervention with discussion of social, health or lifestyle problems, preparation and timing for pregnancy, family history, rubella immunisation, referrals for health problems, and a reminder card. The primary outcome was defined as a birth weight difference in the second birth of 100 g (one-sided) in favour of the intervention. Additional data collected were gestational age, perinatal deaths and birth defects. Analyses used EPI-INFO and STATA.ResultsIntervention and comparison groups were comparable on socioeconomic factors, prior reproductive history and first birth outcomes. Infant birth weight in the second birth was lower (-97.4 g,)) among infants in the intervention arm. There were no significant differences between intervention and comparison arms in the proportion of women having a preterm birth, an infant with low birthweight, or an infant with a birth weight <10th percentile. There were more adverse outcomes in the intervention arm: ten births <32 weeks), compared with one in standard care, and more infants with a birth weight <2000 g, 16 compared with two in standard careConclusionAs the primary outcome was envisaged to be either improved birth weight or no effect, the study was not designed to identify the alternative outcome with confidence. Despite widespread support for pre-pregnancy interventions to improve maternal and perinatal health, this first randomised controlled trial of a multi-component intervention provided at home, did not have a beneficial outcome.

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Effect of paternal alcohol consumption before conception on infant birth weight

Cited by 41 publications

References 20 publications

The Effect of Preconception Paternal Alcohol Exposure on Epigenetic Remodeling of the H19 and Rasgrf1 Imprinting Control Regions in Mouse Offspring

The Effect of Preconception Paternal Alcohol Exposure on Epigenetic Remodeling of the H19 and Rasgrf1 Imprinting Control Regions in Mouse Offspring

Alcohol use by pregnant women: partners, knowledge, and other predictors.

Aiming to increase birth weight: a randomised trial of pre-pregnancy information, advice and counselling in inner-urban Melbourne

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