Effect of paternal age on semen parameters and live birth rate of in-vitro fertilisation treatment: a retrospective analysis

Lai, Shui Fan; Li, Raymond; Yeung, Wsb; Ng, Ernest H.Y.

doi:10.12809/hkmj177111

Cited by 8 publications

(9 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The prognostic reliability of male semen analysis for success with ART is poor 38 . We observed that all parameters, except morphology, of semen analysis deteriorated with increasing male age, as has been shown previously 14,39 . Semen analysis quality was consistent across most male ages in our study up to age 50 years, with approximately 60% of men achieving values within the reference range according to the WHO criteria 24 .…”

Section: Discussionsupporting

confidence: 78%

“…38 We observed that all parameters, except morphology, of semen analysis deteriorated with increasing male age, as has been shown previously. 14,39 Semen analysis quality was consistent across most male ages in our study up to age 50 years, with approximately 60% of men achieving values within the reference range according to the WHO criteria. 24 Over 50 years of age, only 42% of men met the WHO criteria for semen analysis across all parameters.…”

Section: Discussionsupporting

confidence: 66%

See 1 more Smart Citation

Paternal age over 50 years decreases assisted reproductive technology (ART) success: A single UK center retrospective analysis

Morris

Mavrelos

Odia

et al. 2021

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

Introduction: To study whether paternal age exerts an effect, independent of maternal age, on the outcomes of fresh in vitro fertilization/ intracytoplasmic sperm injection (IVF/ICSI) cycles. Semen quality deteriorates with increasing paternal age; however, there is conflicting evidence for any impact paternal age may have on the outcome of IVF/ICSI. Several retrospective and prospective cohort studies have shown that paternal age increases the miscarriage rate and reduces the live birth rate. Some studies have shown no effect of paternal age on live birth rate or miscarriage rate. Studies involving donor oocytes have tended to show no independent effect of paternal age on assisted reproductive technology (ART) outcomes. The age at which paternal age may exert a significant deleterious effect on outcome is not known and there is no limit to paternal age in IVF/ICSI treatment. Material and methods:A single-center retrospective cohort study was carried out at the Centre for Reproductive and Genetic Health, London, UK. Included in the analysis were all couples with primary or secondary infertility undergoing IVF/ICSI cycles in which the male partner produced a fresh semen sample and the cycle proceeded to fresh embryo transfer. All cycles of IVF/ICSI that used donor oocytes-donor sperm, frozen sperm, cycles leading to embryo storage and cycles including preimplantation genetic testing (PGT-A/PGT-M)-were excluded from analysis. The primary outcome was live birth rate and secondary outcomes were clinical pregnancy rate and miscarriage rate. Multivariate logistic regression analysis with live birth as a dependent variable and maternal and paternal age class as independent variables was performed. Results: During the study period there were 4833 cycles, involving 4271 men, eligible for analysis; 1974/4833 (40.8%, 95% confiene intervals [CI] 39.5-42.2%) cycles resulted in a live birth. A significantly lower proportion of men over 51 years met World Health Organization semen analysis criteria (56/133, [42.1%, 95% CI 34.1-50.6]) compared with men under 51 years of age (2530/4138 [61.1%, 95% CI 60.0-62.6]) (p = 0.001). Both maternal and paternal age were retained in the multivariate model | 1859 MORRIS et al. | MATERIAL AND ME THODSThis was a retrospective cohort study conducted at the Centre for Reproductive and Genetic Health, London, UK.Data for in vitro fertilization (IVF) cycles carried out in our unit are held on a clinical database (IDEAS, version 6 Mellowood Medical software). We created a database query to retrieve data on all couples that underwent an IVF or intracytoplasmic sperm injection (ICSI) cycle with fresh embryo transfer from 1 December 2009 to 1 August 2018. We excluded cycles that used donor gametes (oocytes/sperm) and those that used frozen or surgically retrieved sperm. Our study did not include donor oocyte cycles to allow analysis of the effect and for all maternal age subgroups the probability of live birth decreased with paternal age over 50 years (odds ratio [OR] 0.674, 95% CI 0.482-0.943) (p = 0...

show abstract

Section: Discussionsupporting

confidence: 78%

Section: Discussionsupporting

confidence: 66%

Paternal age over 50 years decreases assisted reproductive technology (ART) success: A single UK center retrospective analysis

Morris

Mavrelos

Odia

et al. 2021

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

show abstract

“…Выявленное у обследованных нами мужчин возраст-ассоциированное снижение объема эякулята согласуется с данными литературы [7,28] и может быть связано с возрастным изменением работы предстательной железы. Количество сперматозоидов в эякуляте также статистически значимо снижается с возрастом.…”

Section: Discussionunclassified

“…Возможно также негативное влияние на сперматогенез заболеваний различных органов и систем [29], количество и тяжесть которых существенно повышаются с возрастом человека. Имеющиеся в литературе сведения противоречивы: в исследовании [28] показано, что с возрастом происходит увеличение концентрации сперматозоидов и не изменяется их общее количество в эякуляте; согласно другим работам [10,30] -концентрация и количество сперматозоидов стабильны и эти показатели не связаны с возрастом. По данным российских авторов [13], у бесплодных мужчин старше 45 лет также выявлено снижение количества сперматозоидов в эякуляте.…”

Section: Discussionunclassified

Comprehensive analysis of male ejaculate from infertile couples in the age aspect

Епанчинцева¹,

Селятицкая

Янковская

2021

Androl. genit. hir.

View full text Add to dashboard Cite

Introduction. According to Russian Association of Urology a number of infertile couples ranges from 8 to 17.2 % in various regions of Russia. One of the causes of which is the male factor. Raising the age of the father reduces the chance of conception, increases the risk of early termination of pregnancy and the risk of certain diseases of the child. In this regard the existing knowledge of age-related changes in ejaculate parameters needs to be de veloped. This is particularly true for men of infertile couples.The study objective – to investigate the age patterns of change in the spermological status of infertile men and identify the most age-related variations.Materials and methods. Research design – observation, retrospective, crossection. Analysis of the medical records of 517 Novosibirsk male residents from couples with infertility in marriage was made. The sampling is divided into 5 age groups: 1st group (n = 108) – men of ≤29.9 years old; 2nd group (n = 171) – 30.0–34.9 years old; 3rd group (n = 130) – 35.0–39.9 years old; 4th group (n = 68) – 40.0–44.9 years old; 5th group (n = 40) – ≥45.0 years old.Results. Median of male age in total sample – 34 years, frequency of persons over 40 years – 21 %. Overall sample shows a decline in reference values of proportion of morphologically normal forms – 3.0 (1.5–5.0) % and increase in sperm DNA fragmentation index (SDFI) – 16.0 (11.0–22.2) %. In groups from 1st to 5th there is an age-specific decrease in ejaculate volume (3.5 (2.5–4.8) ml; 3.3 (2.4–4.2) ml; 3.2 (2.4–4.5) ml; 3.0 (1.7–4.9) ml; 2.7 (1.9–3.5) ml, р1–5 <0.005) and sperm count (127.1 (58.8–264.0) million; 122.5 (62.4–214.0) million; 118.5 (52.8–217.5) million; 98.0 (58.5–199.5) million; 81.0 (36.5–137.9) million, р1–5, 2–5 <0.005). SDFI has an age-associated increase in the value of the indicator (14.4 (10.8–19.5) %; 15.0 (10.0–21.0) %; 17.2 (11.0–22.0) %; 18.5 (14.0–24.2) %; 19.2 (13.2–29.6) %, р1–4 <0.005).Conclusion. It was first time shown for the male population of Novosibirsk of Siberian Federal District that a reduction in the proportion of morphologically normal sperm below the reference values observed in the total sample and it did not depend on the age of the men examined. Only three of the examined indicators of sperm status studied infertile males had a significant age dependency: ejaculate volume decrease, reduction of total sperm, increased DNA fragmentation of sperm. The lack of a reliable influence of age on HBA-test indicators was first shown. However the trends identified require further study. The results show that age-associated increase in DNA fragmentation of sperm starts with young men under 30, and underscores the need to define SDFI in actual clinical practice. And negative processes of age influence on the quantitative, morphological and ultrastructural characteristics of sperm occur most frequently in men after 40 years.

show abstract

“…Since that review, a number of larger cohort studies have been performed, however, the results of these studies have been contradictory. Some studies have found that paternal age has a detrimental effect on outcome (19)(20)(21)43) and others have not found evidence of a detrimental effect (21,30,44,45). A systematic review of studies performed using the donor egg model suggested that advancing paternal age is not associated with adverse oocyte donation outcomes (17).…”

Section: Discussionmentioning

confidence: 99%

Effect of paternal age on outcomes in assisted reproductive technology cycles: systematic review and meta-analysis

et al. 2020

View full text Add to dashboard Cite

Objective: To investigate whether paternal age exerts an independent effect on the clinical outcomes of assisted reproductive technology (ART) cycles. Evidence Review: Observational studies were identified through a systematic search of MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and National Health Service evidence. Data for women aged %39 years were extracted and analyzed. We included all studies, both autologous and donor oocyte, into separate analyses of the effect of paternal age on ART outcome. We excluded studies in azoospermic men, women aged R40 years, ART including preimplantation genetic testing, and involving donor sperm. The included studies scored well on the Newcastle-Ottawa Quality Assessment Scale for observational studies. The primary outcome was live birth rate and secondary outcome measures were clinical pregnancy rate and miscarriage rate. When pooling data, the random-effects model was used to counter the effect of heterogeneity in the studies. Result(s): Live birth rate was reported in three autologous oocyte studies (2,926 cycles) and five donor oocyte studies (7,648 cycles). Live birth rate was found to be increased significantly when male age was <40 years in autologous oocyte studies but no difference in live birth rate was found in donor oocyte studies. Clinical pregnancy rates were found to be statistically higher when the paternal age was under 40 years in autologous oocyte studies, however, there was no difference in clinical pregnancy in the same age category when donor oocyte studies were analyzed. Miscarriage rate was reported in two autologous oocyte studies (970 cycles) and four donor oocyte studies (3,741 cycles). Miscarriage was found to be more likely with male age >40 years in autologous studies. In donor oocyte studies, the miscarriage rate was not increased when male age was >50 years. All of the autologous oocyte studies reported a statistically significant association between male age and female age. Conclusion(s): The findings of this review and meta-analysis, based on the donor oocyte model, suggest that advanced paternal age does not exert an independent effect on the outcome of ART cycles. Miscarriage rates do not appear to be increased even for men >50 years of age after treatment with donor oocytes. The meta-analysis of autologous oocyte studies suggests that increasing male age may have a deleterious effect on the outcome of ART, however, this may be confounded by the strong association with increasing maternal age. (Fertil Steril Rev Ò 2020;1:16-34. Ó2020 by American Society for Reproductive Medicine.

show abstract

Effect of paternal age on semen parameters and live birth rate of in-vitro fertilisation treatment: a retrospective analysis

Cited by 8 publications

References 34 publications

Paternal age over 50 years decreases assisted reproductive technology (ART) success: A single UK center retrospective analysis

Paternal age over 50 years decreases assisted reproductive technology (ART) success: A single UK center retrospective analysis

Comprehensive analysis of male ejaculate from infertile couples in the age aspect

Effect of paternal age on outcomes in assisted reproductive technology cycles: systematic review and meta-analysis

Contact Info

Product

Resources

About