“…Nonetheless, more recent approaches have solved this issue by selecting a region of interest for which a cell-based model is used to evaluate tumour growth dynamics. Subsequently, this detailed description can be integrated into a continuum approach [130] ,reducing the computational power required to study the effect of tumour growth at this level.Certainly, it would be invaluable to use these approaches to recognize how metabolic reprogramming may influence the evolution of a tumour at the tissue level.…”