Effect of partial hepatectomy on content of DNA, RNA, and protein in the liver of rabbits with thyrotoxicosis

Panachin, E. F.; Кандрор, В. И.

doi:10.1007/bf00788599

Cited by 1 publication

(3 citation statements)

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“…Panachin [464] also observed an increase in the total RNA concentration in the liver of rabbits with relatively mild thyroid overdosage. The uptake of label into RNA was accelerated.…”

Section: Metabolismmentioning

confidence: 86%

“…After subcutaneous injection of a single large dose of thyroxine (400 !A g) into rats, the protein content in the liver was initially increased, but it soon fell below the initial level [584]. Panachin and Kandror [464] found that the initial stages of thyrotoxicosis produced in rabbits by administration of thyroid extract are accompanied by an increase in the concentration and synthesis of protein in the liver (as reflected in the incorporation of 14 C-glycine}, but the degree of this increase was progressively reduced as the administration of thyroid extract continued. In the hearts of these animals Kandror et al [314,315] found an initial acceleration of incorporation of labeled methionine and glycine into protein (including into actomyosin), followed by inhibition of this process (in severe toxicosis).…”

Section: Metabolismmentioning

confidence: 98%

“…Prolonged administration of thyroxine or TSH to guinea pigs considerably inhibits the drawing together of the surface during healing of skin wounds whereas thyroidectomy does not affect this process [427]. It was shown in Gol'ber's laboratory that the increase in the concentration and synthesis of nucleic acids and protein in the liver after partial hepatectomy is reduced in rabbits with thyrotoxicosis [464]. These facts show that an excess of thyroid hormones inhibits regeneration.…”

Section: Tissue Growth and Differentiationmentioning

confidence: 99%

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Physiological Effects of the Thyroid Hormones

et al. 1975

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The thyroid gland has a powerful influence over the activities of the whole body. If the function of the gland is for any reason lost, serious disturbances of chemical and morphological structure arise and are manifested as physical and mental disorders. The diversity of the action of thyroid hormones on physiological functions, on the metabolic rate, and on the activity of various enzyme systems both in the body as a whole and in tissue preparations has been known for a long time. Our knowledge of the role of thyroid hormones is based on experiments in which a particular thyroid hormone has been given to healthy and athyrotic animals and on extensive clinical observations on patients with hyperthyroid and hypothyroid states.The effect of thyroid hormones in vivo is expressed as reactions of whole organs and of individual physiological functions and morphological structures. The internal secretions of the thyroid gland modify growth and metamorphosis, the utilization of oxygen by the body as a whole or by tissue preparations in vitro, various aspects of metabolism, and the activity of particular enzyme systems.The extreme diversity of the effects observed after injection of thyroid hormone may reflect the primary action of this agent on a single link fundamental to the mechanism of biochemical processes in the cell or on a single morphological structure responsible for the proper integration of processes at the cell level. These problems will be examined fully later. Here I shall merely state that when the action of a thyroid hormone is discussed, the term is used not only with respect to the thyroxine and triiodothyronine produced in the thyroid gland, but also to several of their derivatives and analogs. However, we know that all compounds with the biological activity 125 Y. K. Turakulov et al., Thyroid Hormones

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“…Panachin [464] also observed an increase in the total RNA concentration in the liver of rabbits with relatively mild thyroid overdosage. The uptake of label into RNA was accelerated.…”

Section: Metabolismmentioning

confidence: 86%