Effect of Partial Devascularization on the Blood Flow Distribution in the Cat Stomach

Varhaug, Jan Erik; Skarstein, A; Søreide, Odd; Svanes, Knut

doi:10.1159/000127965

Cited by 2 publications

(3 citation statements)

References 10 publications

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“…We have previously found a regional decrease in mucosal blood flow after partial devascularization of the stomach in cats (20). In the present experiment we found decreased mucosal blood flow after devascularization in animals given pentagastrin, which is known to cause vasodilatation and increased blood flow in the acid-secreting part of the mucosa in cats (17).…”

Section: Discussionsupporting

confidence: 71%

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Effect of Partial Gastric Devascularization on Mucosal Blood Flow and Acid Secretion in Cats

Varhaug¹,

Svanes²,

Søreide³

et al. 1979

Eur Surg Res

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Partial devascularization of the stomach was performed in cats anesthetized with pentobarbital. The devascularization included all blood vessels along the greater curvature and two of the main branches of the left gastric artery. Gastric mucosal blood flow and cardiac output were determined by means of the microsphere distribution technique. The acid (H⁺) output from the 30th to the 60th min of pentagastrin stimulation was used as the ‘acid response value’. Blood flow and acid secretion were determined before and approximately 2 h after devascularization or sham operation. A marked decrease in acid secretion and mucosal blood flow of the corpus/fundus occurred after devascularization. A high degree of correlation was found between the decrease in acid secretion and the decrease in mucosal blood flow caused by the devascularization. The regression coefficient of acid secretion on mucosal blood flow did not change significantly after devascularization.

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Section: Discussionsupporting

confidence: 71%

“…In a previous study regional reduction in gastric blood flow was found after partial devascularization (20). The present investigation was undertaken to study the effect of partial gastric devascularization on acid secretion and mucosal blood flow to the acid-secreting part of the stomach.…”

Section: Introductionmentioning

confidence: 88%

Effect of Partial Gastric Devascularization on Mucosal Blood Flow and Acid Secretion in Cats

Varhaug¹,

Svanes²,

Søreide³

et al. 1979

Eur Surg Res

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“…The effect of partial devascularization of the stomach on the gastric blood flow has been investigated during experimental conditions in animals [3,4]. Laser Doppler flowmetry (LDF) is a method which has been proven capable of reflecting changes in the gastric blood flow in animals, and in a previous study we have shown that it is a practical means of studying gastric circulation endoscopically in conscious man [5][6][7].…”

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confidence: 99%

Effect of proximal gastric vagotomy on human gastric blood flow evaluated by endoscopic laser doppler flowmetry

1988

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The effect of proximal gastric vagotomy (PGV) on gastric blood flow has been evaluated endoscopically by laser Doppler flowmetry (LDF) in 12 patients with duodenal ulcer. The gastric wall circulation was examined at 7 defined positions in all subjects prior to surgery, 1 week postoperatively, and after 3 months. For comparison, 21 healthy volunteers were also examined by LDF. In all the investigated areas of the stomach, the blood flow values were lower in the unoperated duodenal ulcer patients than in the controls. In both groups, the blood circulation was significantly lower at the lesser curvature than at the greater curvature. Seven days after PGV, the blood flow was reduced 30% in the devascularized part of the lesser curvature. After 3 months, the flow values were similar to the preoperative ones. The gastric acid secretion was significantly reduced at 3 months. Postoperatively, one patient developed a gastric ulcer in the dissected area of the lesser curvature. This patient had lower flow values along the lesser curvature than the other patients after 7 days. The results of this study show that PGV leads to a temporary reduction of blood flow at the lesser curvature. This regional decrease in blood flow is probably not an important factor for the reduced acid secretion measured after PGV.

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Effect of Partial Devascularization on the Blood Flow Distribution in the Cat Stomach

Cited by 2 publications

References 10 publications

Effect of Partial Gastric Devascularization on Mucosal Blood Flow and Acid Secretion in Cats

Effect of Partial Gastric Devascularization on Mucosal Blood Flow and Acid Secretion in Cats

Effect of proximal gastric vagotomy on human gastric blood flow evaluated by endoscopic laser doppler flowmetry

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