Effect of partial crystallization on the mechanical properties and cytotoxicity of bioactive glass from the 3CaO.P2O5–SiO2–MgO system

Daguano, J.K.M.F.; Strecker, Kurt; Ziemath, Ervino C.; Rogero, Sizue Ota; Fernandes, Maria Helena; Santos, Claudinei dos

doi:10.1016/j.jmbbm.2012.04.024

Cited by 35 publications

(28 citation statements)

References 34 publications

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“…In this work (Daguano et al, 2012) it was related that the presence of whitlockite increases mechanical properties such as bending strength and hardness, probably due to the fact that the crystallization process can act as an toughening mechanism, as the acicular whitlockite phase causes crack-deflection. However, the same study (Daguano et al, 2012) indicates that this increase on mechanical properties can be lost with heat-treatments over 1100ºC, due to the increased porosity. Similar results were indicated in studies conducted with bioactive glassceramic from the P 2 O 5 -Na 2 O-CaO-SiO 2 system.…”

Section: Discussionmentioning

confidence: 98%

“…(Daguano et al, 2013) Another work by Daguano et al (Daguano et al, 2012) discussed the mechanical properties of bioactive glass-ceramic with whitlockite as their crystalline phase. In this work (Daguano et al, 2012) it was related that the presence of whitlockite increases mechanical properties such as bending strength and hardness, probably due to the fact that the crystallization process can act as an toughening mechanism, as the acicular whitlockite phase causes crack-deflection. However, the same study (Daguano et al, 2012) indicates that this increase on mechanical properties can be lost with heat-treatments over 1100ºC, due to the increased porosity.…”

Section: Discussionmentioning

confidence: 99%

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In vitro study of dentin hypersensitivity treated by whitlockite glass-ceramics

2017

Preprint

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

In vitro study of dentin hypersensitivity treated by whitlockite glass-ceramics

2017

Preprint

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“…In these studies sintered glass-ceramics belonging to the pseudo-binary system albite-diopside, which form different percentages of diopside, were used. Later P CR formation was confirmed in other sintered glass-ceramic systems [53][54][55][56][57][58][59][60][61][62], as well as in some new ceramics with high crystallinity [63][64][65]. During sinter-crystallization, processes of densification and crystal phase formation take place in the same temperature interval.…”

Section: Introductionmentioning

confidence: 89%

8. Stress-induced Pore Formation and Phase Selection in a Crystallizing Stretched Glass

Fokin¹,

Karamanov²,

Abyzov³

et al. 2014

Glass

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In the present chapter, we describe results of experimental investigations and theoretical analysis of phase selection and nucleation of pores in small samples of undercooled diopside liquid when it is enclosed by a solid crystalline surface layer. The formation of the surface crystalline layer starts with nucleation and growth of highly dense diopside crystals. At the moment of impingement of these crystals on the sample surface, the crystallization pathway switches from diopside to a wollastonite-like (WL) phase. The origin of such switch can be explained by the fact that the formation of the WL-crystal produces less elastic stress energy than the same amount of diopside. This difference is due to the lower (as compared to diopside) density of the WL-crystal phase, which is closer to the liquid density. The relative content of the two crystalline phases can be changed by varying the sample size. Due to the density misfit the growth of the WL-crystalline layer leads to uniform stretching of the encapsulated liquid. This negative pressure leads finally to the formation of one small pore, which rapidly grows up to a size that almost eliminates the elastic stress and, therefore, dramatically reduces the driving force for further pore nucleation. The nucleation process of the pore is experimentally found to occur in a very narrow range of the relative widths of the surface layer (compared to the sample size) and, consequently, of negative pressures. We consider this fact as an indication that pore nucleation proceeds via homogeneous nucleation. The above-given qualitative explanation of the observed phenomena is corroborated by detailed theoretical calculations of elastic stress fields and their impact on phase selection and pore nucleation. Good qualitative and partly even quantitative agreement between experiment and theory is found. An overview on other systems with similar or related properties is included as well. The findings of this research are quite general because the densities of most glasses significantly differ from those of their iso-chemical crystals. By this reason, the studied phenomena are of high technological significance for the development of different types of glass-ceramic materials and the understanding and control of sinter-crystallization processes. The latter problem is also considered in the present chapter.

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“…For instance, Santocildes-15 Romero et al 23 have showed an increase of the cytotoxic effect of BGs dissolution by increasing 16 the amount of glass powders used and the level of strontium substitution added to the glass 17 for the treatment of osteoporosis 21 . 24 Various studies have been reported concerning the use of heat treatments in order to induce 25 crystallisation in BGs to promote changes in their physico-chemical properties [27][28][29][30][31] . For instance, 26…”

Section: Introductionmentioning

confidence: 99%

“…However, few authors have reported that the formation of new crystalline phases 11 provoked the modification of toxic effects induced by the glasses in cells 27,30 . Specially, Hurrell-12…”

Section: Introductionmentioning

confidence: 99%

Design and Properties of Novel Substituted Borosilicate Bioactive Glasses and Their Glass-Ceramic Derivatives

Fernandes

Gentile

Moorehead

et al. 2016

Crystal Growth & Design

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1Three novel borosilicate bioactive glasses (BBGs) of general formula of 0.05Na2O0.35x 2 0.20B2O30.40SiO2 (molar ratio, where x = MgO or CaO or SrO) were prepared and used to 3 investigate the effect of crystallisation on their properties including cytotoxicity. The three post-4 melt compositions were determined using X-ray fluorescence spectroscopy and crystallisation 5 events were studied using differential thermal analysis and x-ray diffraction. This information was 6 used to determine heat treatments to prepare glass-ceramics by controlled crystallisation. X-ray 7 diffraction analysis and Fourier transform infrared spectroscopy showed that, after higher heat 8 treatment temperatures (800-900 ºC), borosilicate bioactive glass-ceramics (BBGCs) contained 9 mainly borate and silicate crystalline phases. Specifically, BBG-Mg, BBG-Ca and BBG-Sr glass-10 ceramics detected the presence of magnesium silicate-Mg2(SiO3)2 and magnesium borate-Mg2B2O5; 11 wollastonite-2M-CaSiO3 and calcium borate-Ca(BO2)2; and strontium silicate-SrSiO3 and strontium 12 borate-Sr2B2O5, respectively. In vitro cytotoxicity tests were performed using the mouse fibroblast 13 cell line (L929). Glass and glass ceramic at concentrations lower than 50 mg/ml did not exhibit any 14 level of cytotoxicity when compared with the control. However, quantitative evaluation indicated 15 that greater cell growth occurred in the presence of materials with crystalline phases. Control of 16BBGs crystallisation may therefore be used to influence the biocompatibility of these glass-ceramic 17 systems. 18

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Effect of partial crystallization on the mechanical properties and cytotoxicity of bioactive glass from the 3CaO.P2O5–SiO2–MgO system

Cited by 35 publications

References 34 publications

In vitro study of dentin hypersensitivity treated by whitlockite glass-ceramics

In vitro study of dentin hypersensitivity treated by whitlockite glass-ceramics

8. Stress-induced Pore Formation and Phase Selection in a Crystallizing Stretched Glass

Design and Properties of Novel Substituted Borosilicate Bioactive Glasses and Their Glass-Ceramic Derivatives

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