Effect of Parkia speciosa Hassk Peels Extract on Total Cholesterol Levels of Hypercholesterolemia Rats

Tandi, Joni; Handayani, Tien Wahyu; Tandebia, Maria; Wijaya, Jessica Anastasia

doi:10.37506/ijfmt.v14i4.12045

Cited by 4 publications

(3 citation statements)

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“…A study by Tandi et al (2020) showed the effects of ethanol extract of P. speciosa peels on total cholesterol levels in the hypercholesterolemia rat model [ 71 ]. In that study, oral administration at the dose of 300 mg/kg daily reduced 52.73% of total cholesterol levels in hypercholesterolemia mice compared to the negative control group after 35 days.…”

Section: Pharmacological Potential Of P Speciosa E...mentioning

confidence: 99%

“…In that study, oral administration at the dose of 300 mg/kg daily reduced 52.73% of total cholesterol levels in hypercholesterolemia mice compared to the negative control group after 35 days. The effect of P. speciosa extract was comparable with the effect of simvastatin, which reduced total cholesterol levels by 57.27% [ 71 ].…”

Section: Pharmacological Potential Of P Speciosa E...mentioning

confidence: 99%

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Phytochemical Contents and Pharmacological Potential of Parkia speciosa Hassk. for Diabetic Vasculopathy: A Review

et al. 2022

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Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and is considered a major health problem in the world. It is associated with endothelial dysfunction which causes progressive vascular damage. DM is a known risk factor for atherosclerosis and cardiovascular complications such as peripheral artery disease, coronary artery disease, and stroke. Medicinal plants may act as an alternative resource or adjunctive treatment option in the treatment of diabetes and its cardiovascular complications. Parkia speciosa (Fabaceae) is a plant found abundantly in the Southeast Asian region. Its seeds, with or without pods, and roots have long been used as a traditional medicine in this region to treat hypertension and diabetes. Studies have shown its numerous beneficial pharmacological properties. Extracts of P. speciosa, particularly from its seeds and empty pods, show the presence of polyphenols. They also exhibit potent antioxidant, hypoglycemic, anti-inflammatory, and antihypertensive properties. Its hypoglycemic properties are reported to be associated with the presence of β-sitosterol, stigmasterol, and stigmat-4-en-3-one. The current review aimed to provide an overview of the current status of P. speciosa, its pharmacological potential, and its phytochemical content in attenuating diabetic vasculopathy. Glycemic status, oxidative stress, inflammation, and hyperlipidemia are known to play pivotal roles in the initiation and severity of diabetic cardiovascular diseases; thus, targeting these factors might be beneficial for preventing and/or treating diabetic vasculopathy.

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Section: Pharmacological Potential Of P Speciosa E...mentioning

confidence: 99%

Section: Pharmacological Potential Of P Speciosa E...mentioning

confidence: 99%

Phytochemical Contents and Pharmacological Potential of Parkia speciosa Hassk. for Diabetic Vasculopathy: A Review

et al. 2022

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“…Half of this figure is in Asia such as India, China, and Indonesia. Indonesia is the 6th country with the most diabetes sufferers in the world (Tandi et al, 2020a).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Ethanol Extract of Guava (Psidium guajava L) Leaf on Hypercholesterolemia-Diabetic White Rats Male Induced by High Fat Feed and Streptozotocin

Tandi¹,

Pratiwi²,

Surisna³

et al. 2021

JFG

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This study aims to determine the effect of guava leaf extract (Psidiium guajava L) on hypercholesterolemia-diabetes and the effective dose for reducing cholesterol and blood glucose levels. This study is a laboratory experimental study using 30 rats divided into 6 test animals. the treatment group, each group consisted of 5 rats. Group I was normal control, group II negative control was given Na-CMC suspension, group III positive control was given simvastatin group IV dose 150 mg / kg BW, group V dose 250 mg / kg BW and group VI dose 350 mg / kg BW. The results showed that the ethanol extract of guava leaves had an effect on reducing blood glucose levels of male white rats with an effective dose of 250mg / kg BW with an average reduction of 119 mg/dL and effectively reduce cholesterol levels at a dose of 150 mg /kg BW with an average reduction of 28,33 mg/dL.

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Test effects of Ethanol Jatropha gossypifolia L extract against Diabetic Nephropathy

tandi¹,

NFR²,

Herlambang.³

et al. 2022

RJPT

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Background: The prevalence of diabetes mellitus patients in Central Sulawesi is 2.2%. Diabetes mellitus in the long term with uncontrolled glucose levels can cause various complications, one of which is diabetic nephropathy. Diabetic nephropathy is a complication of DM in the kidneys that occurs due to a decrease in the glomerular filtration rate and can end in kidney failure. Objective: The purpose of the study is suggested evaluate (Jatropha gossypifolia L) ethanol extract of diabetic nephropathy on male white rats (Rattus norvegicus) induced by streptozotocin 40mg/kg BW intraperitoneally with dose variations of 300mg/kg BW, 400mg/kg BW and a dose of 500mg/kg BW. Method: This study used 30 male white rats divided into 6 groups, namely group I as normal control, group II as positive control (glibenclamide), group III as negative control (Na-CMC 0.5%), group IV, V and VI as control. the test group was given ethanol extract of red jatropha leaves with each dose of 300mg/kgBW, 400mg/kgBB, 500mg/kgBW. The data were analyzed using the one way ANOVA test at the 95% confidence level, and continued with the LSD post hoc test. Result: The results of this study indicate that the ethanol extract of red jatropha leaves contains secondary metabolites, namely flavonoids, alkaloids, phenols, saponins, tannins and can reduce blood glucose levels with a value of 108.0mg/dl, urea 18.2 mg/dl, creatinine 0, 23mg/dl and has an effect on the regeneration of renal tubular cells with a damage value of 1 out of a maximum of 2. Conclusion: This research only took place in on the 21st day and surgery was performed because the condition of the test animals showed toxic characteristics with foam in the mouth, dark eyes, limp, not aggressive and not moving due to the toxic effects of ricin poison which is a compound of toxalbumin, so this research has no potential as therapy. diabetic nephropathy.

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Effect of Parkia speciosa Hassk Peels Extract on Total Cholesterol Levels of Hypercholesterolemia Rats

Cited by 4 publications

References 0 publications

Phytochemical Contents and Pharmacological Potential of Parkia speciosa Hassk. for Diabetic Vasculopathy: A Review

Phytochemical Contents and Pharmacological Potential of Parkia speciosa Hassk. for Diabetic Vasculopathy: A Review

The Effect of Ethanol Extract of Guava (Psidium guajava L) Leaf on Hypercholesterolemia-Diabetic White Rats Male Induced by High Fat Feed and Streptozotocin

Test effects of Ethanol Jatropha gossypifolia L extract against Diabetic Nephropathy

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