Effect of parathyroid extract on magnesium excretion in man.

Gill, Jr Jr; Nh, Bell; Fc, Bartter

doi:10.1152/jappl.1967.22.1.136

Cited by 43 publications

(12 citation statements)

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“…lb, day 12). This effect of PTE is a highly reproducible one in HP (19). No transient decrease in urinary calcium was demonstrated with dibutyryl cyclic AMP in any of the patients with PHP or HP.…”

Section: Introductionmentioning

confidence: 58%

“…As noted already, changes in mean CP were considerably less with PTE than with dibutyryl cyclic AMP. There were no transient decreases in urinary calcium to indicate an augmentation in the renal tubular reabsorption of calcium (18,19). In contrast, this effect of PTE on urinary calcium was clearly demonstrated on the 1st day of PTE administration in both patients with surgical HP (Fig.…”

Section: Introductionmentioning

confidence: 90%

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Effects of Dibutyryl Cyclic Adenosine 3′,5′-Monophosphate and Parathyroid Extract on Calcium and Phosphorus Metabolism in Hypoparathyroidism and Pseudohypoparathyroidism

Bell¹,

Avery²,

Sinha³

et al. 1972

J. Clin. Invest.

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A B S T R A C T It has been proposed previously that the metabolic defect in pseudohypoparathyroidism which accounts for parathyroid hormone unresponsiveness is an absence or abnormal form of the adenyl cyclase system in kidney and presumably in bone. To determine whether there is an associated defect in the response mechanism to cyclic adenosine 3',5'-monophosphate (cyclic AMP), the effects of parathyroid extract (PTE), and dibutyryl cyclic AMP were compared in patients with either surgical hypoparathyroidism or pseudohypoparathyroidism. PTE and dibutyryl cyclic AMP both increased serum and urinary calcium, lowered the serum phosphorus, and increased urinary phosphorus in patients with hypoparathyroidism. PTE also increased urinary cyclic AMP in these patients. PTE increased serum and urinary calcium and urinary phosphorus but did not alter serum phosphorus or urinary cyclic AMP in the patients with pseudohypoparathyroidism. Dibutyryl cyclic AMP increased the serum and urinary calcium, lowered the serum phosphorus, and increased urinary phosphorus in all the patients with pseudohypoparathyroidism. The results indicate that (a) dibutyryl cyclic AMP can reproduce the effects of parathyroid hormone on calcium and phosphorus metabolism in man, (b) the response mechanism to cyclic AMP appears to be intact in pseudohypoparathyroidism, and (c) PTE apparently produces some of its characteristic effects on calcium and phosphorus metabolism in pseudohypoparathyroidism in the absence of an increase in urinary cyclic AMP.

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Section: Introductionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 90%

Effects of Dibutyryl Cyclic Adenosine 3′,5′-Monophosphate and Parathyroid Extract on Calcium and Phosphorus Metabolism in Hypoparathyroidism and Pseudohypoparathyroidism

Bell¹,

Avery²,

Sinha³

et al. 1972

J. Clin. Invest.

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“…Even although the urinary excretion of magnesium fell following parathyroidectomy (Table 2; Heaton & Pyrah, 1963), urinary wasting of magnesium before the operation cannot be attributed to the direct action on the kidney of an excess of circulating parathyroid hormone. Evidence from experiments in animals indicates that parathyroid hormone increases the renal tubular reabsorption of magnesium ; and, in acute experiments, administration of parathyroid extract has reduced the urinary output of magnesium in man (Gill, Bell & Bartter, 1967;Shelp, Steele & Rieselbach, 1969). Administration of parathyroid extract has also been shown to cause a slight rise in the serum magnesium in animals (Greenberg & Mackey, 1932;Cheek & Teng, 1960;Wallach, Bellavia & Schorr, 1966) and man (Gill et al, 1967;Zimmett & King, unpublished observations).…”

Section: Discussionmentioning

confidence: 97%

Magnesium Metabolism in Primary Hyperparathyroidism

King

Stanbury

1970

Clinical Science

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1.Magnesium metabolism has been studied in forty-eight patients with primary hyperparathyroidism. Metabolic balance studies were undertaken in forty-three untreated patients and in fifteen patients after parathyroidectomy. The data obtained are compared with the pattern of magnesium metabolism in healthy adults, as established by analysis of collected nutritional studies. The renal handling of magnesium was assessed from measurements of 24-h renal clearances.2. The mean serum magnesium in primary hyperparathyroidism was normal but low levels were present in nine of the forty-eight patients. There was a significant inverse correlation between serum levels of calcium and magnesium.3. The magnesium balance was negative by amounts >5% of the dietary intake in eleven patients, and positive to a similar degree in twenty-one. Patients in negative balance ingested and consequently absorbed less magnesium than those in positive balance ; the negative balance was apparently due to inadequate renal conservation of magnesium in the face of this lower intake and, in some cases, despite a low serum magnesium. When related to the level of dietary intake, intestinal net absorption of magnesium tended to be greater than normal.4. In eleven of twelve patients studied, the urinary output of magnesium was lower after parathyroidectomy irrespective of changes in the serum level of magnesium. This fall in output appeared to depend mainly on reduction in the serum calcium. In untreated patients without advanced secondary renal disease there was a positive correlation between the serum calcium and the clearance ratio CMg/Ccreatinine. Additional mechanisms may contribute to renal loss of magnesium when renal failure is advanced.5. The tendency to develop a negative magnesium balance and hypomagnesaemia in untreated patients of this series thus appeared related to the height of the serum calcium, the presence of advanced secondary renal disease and inadequate dietary intake.

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“…Thus, the clearance of calcium increases during the first few hours after parathyroidectomy in rats [213,214] and dogs [119] even as serum calcium begins to fall. Moreover, the fraction of filtered calcium excreted in the urine of humans with hypopara thyroidism is relatively high, and urinary calcium excretion is reduced by the administration of parathyroid extract in both humans and dogs [22,119,155,233], In patients with hyperparathyroidism and hypercalcemia, urinary cal cium often increases in association with the higher filtered load of this ion; however, for any given level of filtered calcium, the clearance of this ion is lower in patients with hyperparathyroidism than in those with other hypercalcemic disorders [119,218], Although the acute administration of parathy roid extract in humans and experimental animals has generally been found to cause an absolute decrease in urinary calcium or in calcium clearance [19,22,69,71,119,233], others [82,184,214] observed either an increase or no change in urinary calcium. These variable results may be related to an increase in plasma calcium, a rise in GFR, or augmented sodium excretion, all of which may follow the administration of parathyroid extract.…”

Section: Hormonal Factors Affecting Urinary Excretionmentioning

confidence: 99%

The Hormonal and Non-Hormonal Control of Renal Excretion of Calcium and Magnesium

Massry¹,

Jw²

1973

Nephron

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This report reviews the various hormonal and non-hormonal factors involving the renal handling of calcium and magnesium and the effect of these factors on the relationship between the excretions of these divalent ions and that of sodium. Among the factors discussed are: (1) extracellular volume expansion, (2) renal vasodilatation, (3) changes in glomerular filtration rate, Parathyroid hormone (4) hypercalcemia and hypermagnesemia, (5) diuretics, (6) phosphate depletion and loading, (7) alterations in acid base balance, (8) diet, (9) fasting, (10) activity, (11) diurnal variation, and (12) various hormones including parathyroid hormone, calcitonin, vitamin D, growth hormone, thyroid hormone, and adrenal steroids.

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Effect of parathyroid extract on magnesium excretion in man.

Cited by 43 publications

References 0 publications

Effects of Dibutyryl Cyclic Adenosine 3′,5′-Monophosphate and Parathyroid Extract on Calcium and Phosphorus Metabolism in Hypoparathyroidism and Pseudohypoparathyroidism

Effects of Dibutyryl Cyclic Adenosine 3′,5′-Monophosphate and Parathyroid Extract on Calcium and Phosphorus Metabolism in Hypoparathyroidism and Pseudohypoparathyroidism

Magnesium Metabolism in Primary Hyperparathyroidism

The Hormonal and Non-Hormonal Control of Renal Excretion of Calcium and Magnesium

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