Effect of Parasitic Capacitance on Impedance Measurement and Model Extraction

Abstract

Impedance spectroscopy has been widely used for the characterization of materials and structures. An impedance model can be employed to extract electrical parameters ascribed to the electrical properties of material interiors, boundaries, and external material/electrode interfaces. In an impedance model, a parasitic capacitance exerts an important effect, and is thus an essential to be added. In this paper, dramatic impact of parasitics on impedance spectra and parameter extraction is investigated using theoretical analyses, simulations, and physical experiments. A complex nonlinear least squares fitting method based on a parasitic model together with an I-V assisted estimation method is proposed for providing more accurate and efficient parameter extraction than previously available solutions. The results also reveal that the low frequency band (below 1 kHz) is not recommended to be used because the impedance measurements are influenced badly by noise. The moderate frequency band (1 kHz -1 MHz) is a recommended range for parameter extraction.

TEER Measurement Techniques for In Vitro Barrier Model Systems

“…To verify the uniformity of current density, an electrical simulation or modeling study should be performed in cases in which nonconventional electrode designs are incorporated into a TEER measurement system. In custom-designed electrical measurement equipment or setup for impedance spectroscopy-based TEER measurements, it is important to isolate the effects of parasitic capacitance 128 by parameter extraction using theoretical analyses and equivalent circuit simulations.…”

Design and validation of a custom-made system to measure transepithelial electrical impedance in human corneas preserved in active storage machine

“…As corneal impedance in function of current frequency was highly similar to a low-pass filter signal ( Obeid et al, 2017 ), the electrical modeling of cornea was obtained through fitting a passive second order low-pass model to corneal impedance results by iteration ( Zhang and Zhu, 2010 ). The obtained corneal impedance results were compared to electrical models using the simulation software Tina-Ti (Texas Instrument, USA).…”

A Label-Free Electrical Impedance Spectroscopy for Detection of Clusters of Extracellular Vesicles Based on Their Unique Dielectric Properties

“…The following supporting information [ 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 ] can be downloaded at: , Figure S1: (a) NTA results of liposomes CH:PC (1:10) . (b) NTA result of liposomes CH:PC (10:1) synthesized by extrusion method; Figure S2: (a) An in vivo strategy to label EVs with GFP in a hepatocyte-specific manner.…”