Effect of Paper on the Performance Assay in the Control of Antibiotic Sensitivity Discs

Abstract

KRAMER, JULIAN (Food and Drug Administration, Washington, D. C.), AND AMIEL KIRSHBAUM. Effect of paper on the performance assay in the control of antibiotic sensitivity discs. Appl. Microbiol. 9:334-336. 1961.-Antibiotic discs were prepared, using several several batches of papers meeting Food and Drug Administration specifications. The analysis of 1,152 zones of inhibition produced showed no performance differences among these batches. Other discs were prepared using papers of different grades. These produced large differences in performance. It is obvious, therefore, that the use of a specified disc paper is necessary for standardizing the performances of the products of various manufacturers and that reproducible results can be attained with the grade of paper specified.

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“…Antimicrobial susceptibility testing was performed on Mueller-Hinton Agar (Hi-media) plates with sterilized dry filter paper disc 5 loaded with different quantum of the antibiotics ranging from 5 to 0.02 µg by the Kirby-Bauer disc diffusion method.…”

“…It is reasonable to expect that all the drugs contain the same salt and quantity. Thus, a clinician prescribes the medicine with its trade name only 5 .…”

Differential antimicrobial and cellular response of electrolytically metalized halloysite nanotubes having different amounts of surface metallization

“…Due to increased incidences of microbial infections and rising microbial resistance to antibiotics, innovative antimicrobial agents are the need of the present age. [1][2][3] Metal nanoparticles (NPs) exhibit significant antimicrobial activity by themselves [4][5][6] as well as a synergistic activity when combined with other antimicrobial agents, 7,8 however, their utility is restricted due to their inherent instability leading to agglomeration and thus a reduction in potency. Furthermore, at high concentrations their cytotoxic effects outstrip the antimicrobial potential.…”