Effect of pancreatic juice cytology and/or endoscopic ultrasound‐guided fine‐needle aspiration biopsy for pancreatic tumor

Abstract

PJC improved the diagnostic utility of EUS-FNA for pancreatic tumor.

Endoscopic ultrasonography for surveillance of individuals at high risk for pancreatic cancer

“…A recent meta-analysis has demonstrated that EUS-FNA is highly sensitive (89%), specific (96%), accurate (97%) and has a very good positive likelihood ratio (16.08) and an acceptable negative likelihood ratio (0.13) [116] . Moreover, another recent study not included in the meta-analysis previously reported [117] , confirmed these values and has shown that the diagnostic accuracy of EUS-FNA could be further improved by the addition of pancreatic juice analysis. EUS complications are rare and the risk of perforation is similar to standard upper endoscopy (< 0.03%).…”

Efficacy and safety of pancreatic juice cytology by using synthetic secretin in the diagnosis of pancreatic ductal adenocarcinoma

“…It is important to differentiate PDAC from chronic pancreatitis (CP), because the treatments are different, and the prognosis for CP is much better than that for PDAC. A cytopathological diagnosis is desirable before the treatment for pancreatic tumors . EUS−FNA has been widely used because of its excellent precision and low complication rates, but its diagnostic ability has several limitations.…”

“…A cytopathological diagnosis is desirable before the treatment for pancreatic tumors. 15 EUSÀFNA has been widely used because of its excellent precision and low complication rates, but its diagnostic ability has several limitations. In the present study, 13 cases of malignancy (9.4%) that could not be diagnosed with EUS-FNA were pathologically diagnosed by S-PJC.…”

“…In 1992, Nakaizumi reported the safety and high sensitivity of PJC by using porcine secretin for diagnosis of PDAC and, recently, many reports have described magnetic resonance cholangiopancreatography (MRCP) stimulated by synthetic secretin for the assessment of benign pancreatic disorders . We have reported that PJC increased the diagnostic ability of EUS‐FNA for pancreatic tumors . However, there are few reports on improving the diagnostic ability of PJC by using synthetic secretin (S‐PJC) .…”

“…14 We have reported that PJC increased the diagnostic ability of EUS-FNA for pancreatic tumors. 15,16 However, there are few reports on improving the diagnostic ability of PJC by using synthetic secretin (S-PJC). 12 We investigated improving the diagnostic ability of PDAC using synthetic secretin.…”