Effect of Panax notoginseng Saponins and Major Anti-Obesity Components on Weight Loss

Zhang, Xuelian; Zhang, Bin; Zhang, Chenyang; Sun, Guibo

doi:10.3389/fphar.2020.601751

Cited by 26 publications

(20 citation statements)

References 128 publications

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“…Panax notoginseng (Burkill) F.H. Chen could change the fat and inflammation of liver tissue through decreasing expression levels of SREBP1c, ACC, and FAS ( Ji and Gong, 2007 ; Yan-Xia et al, 2011 ; Zhang et al, 2020 ). The expression levels of SREBP1c, ACC, and FAS were downregulated in the Curcuma longa L. groups compared to the HFD groups ( Ejaz et al, 2009 ; Ahn et al, 2010 ; Zhao et al, 2011 ; Mun et al, 2019 ).…”

Section: Targeting Lipid Metabolism With Bioactive Compounds From Tcms With Anti-obesity Effectsmentioning

confidence: 99%

“…Compared with the modern drugs mentioned above, TCMs have been widely used to treat obesity for a very long time. This fact alone suggests that TCMs may be used as a vast resource for the development of natural anti-obesity drugs possessing fewer side effects ( Li et al, 2017 ; Martel et al, 2017 ; Zhang Y. et al, 2018 ; Zhang et al, 2020 ; Ji-Ping et al, 2021 ). While some of the anti-obesity effects and mechanisms of TCMs have been studied in the past decade, most of these studies only focused on single/several genes or signaling pathways involved in lipid metabolism.…”

Section: Introductionmentioning

confidence: 99%

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The Anti-Obesity Effect of Traditional Chinese Medicine on Lipid Metabolism

Fan

Liang

et al. 2021

Front. Pharmacol.

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With the improvement of living conditions and the popularity of unhealthy eating and living habits, obesity is becoming a global epidemic. Obesity is now recognized as a disease that not only increases the risk of metabolic diseases such as type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD), cardiovascular disease (CVD), and cancer but also negatively affects longevity and the quality of life. The traditional Chinese medicines (TCMs) are highly enriched in bioactive compounds and have been used for the treatment of obesity and obesity-related metabolic diseases over a long period of time. In this review, we selected the most commonly used anti-obesity or anti-hyperlipidemia TCMs and, where known, their major bioactive compounds. We then summarized their multi-target molecular mechanisms, specifically focusing on lipid metabolism, including the modulation of lipid absorption, reduction of lipid synthesis, and increase of lipid decomposition and lipid transportation, as well as the regulation of appetite. This review produces a current and comprehensive understanding of integrative and systematic mechanisms for the use of TCMs for anti-obesity. We also advocate taking advantage of TCMs as another therapy for interventions on obesity-related diseases, as well as stressing the fact that more is needed to be done, scientifically, to determine the active compounds and modes of action of the TCMs.

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Section: Targeting Lipid Metabolism With Bioactive Compounds From Tcms With Anti-obesity Effectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Anti-Obesity Effect of Traditional Chinese Medicine on Lipid Metabolism

Fan

Liang

et al. 2021

Front. Pharmacol.

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“…P. notoginseng saponins (PNS) and ginsenosides Rb2 and Rd2 inhibit platelet activity [ 2 – 4 ]. PNS exhibit antiobesity [ 5 ] and antidiabetic properties [ 6 ] and also attenuate nonalcoholic fatty liver disease [ 7 ]. Of note, P. notoginseng is found to be cardio-protective as PNS protect against acute myocardial infarction in mice [ 8 ] and relieve the focal cerebral ischemia-reperfusion in rats [ 9 ], while notoginsenoside R1 promotes angiogenic activity in endothelial cells and zebrafish [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Panax Notoginseng Protects against Diabetes‐Associated Endothelial Dysfunction: Comparison between Ethanolic Extract and Total Saponin

Zhang

Zhou

Miao

et al. 2021

Oxidative Medicine and Cellular Longevity

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Previous studies revealed a cardioprotective potential of Panax notoginseng to relieve acute myocardial infarction and focal cerebral ischemia-reperfusion. However, whether P. notoginseng protects endothelial function in diabetes and the underlying mechanisms remain to be explored. P. notoginseng contains several chemical components including saponins, which are commonly believed as the major bioactive ingredients. The present study was aimed to examine and compare the vaso-protective effects of the ethanolic extract of P. notoginseng (PNE) and total saponin (PNS). Both aortas and carotid arteries were isolated from male C57BL/6J mice for ex vivo treatment with risk factors (high glucose or tunicamycin) with and without the presence of PNS and PNE. Diabetic model was established by feeding the mice with a high-fat diet (45% kcal% fat) for 12 weeks, while PNS and PNE were administrated by oral gavage at 20 mg/kg/day for another 4 weeks. Ex vivo exposure to high glucose impaired acetylcholine-induced endothelium-dependent relaxations in mouse aortas, decreased phosphorylation of AMPK and eNOS, and induced endoplasmic reticulum (ER) stress and oxidative stress. These effects were reversed by cotreatment of PNS and PNE with PNS being more potent. Furthermore, the vaso-protective effects were abolished by Compound C (AMPK inhibitor). Chronic treatment with PNS and PNE improved endothelium-dependent relaxations and alleviated ER stress and oxidative stress in aortas from high-fat diet-induced obese mice. PNE was more effective to improve glucose sensitivity and normalize blood pressure in diabetic mice. The present results showed that PNS and PNE reduced ER stress and oxidative stress and, subsequently, improved endothelial function in diabetes through AMPK activation. This study provides new inspiration on the therapeutic potential of P. notoginseng extract against vascular diseases associated with metabolic disorders.

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“…10 Additionally, Zhang et al reported that P. notoginseng exerts anti-obesity effects by downregulating lipid synthesis, inhibiting adipogenesis, and upregulating energy consumption. 11 Yang et al demonstrated that P. notoginseng can attenuate lung cancer growth partly by modulating the Met/miR-222 axis. 12 Hu et al reported that P. notoginseng attenuates the lipopolysaccharide-induced blood-brain barrier disruption and monocyte adhesion to cerebral endothelial cells in vitro by activating the Nrf2 antioxidant defense system through a PI3K/Akt-dependent mechanism and inhibiting the NF-κB inflammatory signaling pathway.…”

Section: Introductionmentioning

confidence: 99%

Qihu Preparation Ameliorates Diabetes by Activating the AMPK Signaling Pathway in db/db Mice

Zeng

Zhou

et al. 2021

DMSO

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To examine the pharmacological effects of Qihu on type 2 diabetes mellitus using db/db mice. Materials and Methods: Thirty-seven db/db mice were randomly divided into the following 5 groups: diabetes model control group (DM group; n = 7), administered with the adjuvant 0.3% carboxymethyl cellulose-Na; positive control group (Met group; n = 8), administered with metformin (0.13 g/kg bodyweight); Qihu-L group (n = 7), administered with a low dose of Qihu (0.75 g/kg bodyweight), Qihu-M group (n = 7), administered with a medium dose of Qihu (1.5 g/kg bodyweight); Qihu-H group (n = 8), administered with a high dose of Qihu (3.0 g/kg bodyweight). BKS mice (n = 8) were used as the negative control group. The db/db mice were administered with drugs through oral gavage for 28 days. The random blood glucose levels, glucose tolerance test, bodyweight, food intake, and blood lipid levels of the mice were measured during the experimental period. The liver and pancreas tissues were collected for pathological, quantitative real-time polymerase chain reaction, and Western blotting analyses. Results: Compared with the DM group, the Qihu groups exhibited decreased bodyweight gain. The blood glucose levels in the Qihu-L, Qihu-M, and Qihu-H were 31.46%, 43.73%, and 51.83%, respectively, lower than those in the DM group. The triglyceride levels were significantly downregulated and the swelling and steatosis of the hepatocytes were significantly lower in the Qihu-M and Qihu-H groups than in the DM group. Qihu downregulated the expression of IL-1β, IL-6, and TXNIP and upregulated the AMP-activated protein kinase (AMPK) signaling pathway in the pancreas and liver tissues of db/db mice. Conclusion:The anti-diabetic effects of Qihu are mediated through the activation of the AMPK/Txnip signaling and the downregulation of the secretion of inflammatory factors in db/db mice.

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Effect of Panax notoginseng Saponins and Major Anti-Obesity Components on Weight Loss

Cited by 26 publications

References 128 publications

The Anti-Obesity Effect of Traditional Chinese Medicine on Lipid Metabolism

The Anti-Obesity Effect of Traditional Chinese Medicine on Lipid Metabolism

Panax Notoginseng Protects against Diabetes‐Associated Endothelial Dysfunction: Comparison between Ethanolic Extract and Total Saponin

Qihu Preparation Ameliorates Diabetes by Activating the AMPK Signaling Pathway in db/db Mice

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