Abstract:Livers of fasted rats were perfused for one hour at 37" or 42". Endogenous hepatic ureogenesis was increased twofold at 42" and the release of endogenous ninhydrin-reactive amino nitrogen was not changed by hyperthermia. Exogenous amino acids at 10 times the normal plasma concentration stimulated hepatic ureogenesis sevenfold at 37" and over twofold at 42". Exogenous amino acids stimulated hepatic amino acid uptake at 37". Uptake of the exogenous amino acids at 42" was about 40% of that observed at 37". Howeve… Show more
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