Effect of Paired-Pulse Electrical Stimulation on the Activity of Cortical Circuits

Saito, Kei; Onishi, Hideaki; Miyaguchi, Shota; Kotan, Shinichi; Fujimoto, Shuhei

doi:10.3389/fnhum.2015.00671

Cited by 6 publications

(6 citation statements)

References 38 publications

(69 reference statements)

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“…One possible explanation for PES-induced MEP facilitation is the specific timing of direct Ia fiber activation by PES and somatosensory input from contracting muscles. Saito et al (2015) reported MEP potentiation and cortical inhibitory circuit depression following 10 Hz paired-pulse electrical stimulation with 5-ms inter-pulse intervals to the median nerve (mixed nerve) even when stimulus intensity was 80% of MT (i.e., without muscle contraction). Therefore, in the mixed nerve stimulation with muscle contraction condition, M1 excitability may increase if somatosensory inputs from Ia fibers induced by direct electrical stimulation and somatosensory inputs from muscle contraction arrive with a time difference of ~5 ms. On the other hand, Chipchase et al (2011a) showed that the MNS with intensity of muscle twitch at a frequency of 10 Hz did not change, although muscle contraction occurred.…”

Section: Discussionmentioning

confidence: 99%

Presence and Absence of Muscle Contraction Elicited by Peripheral Nerve Electrical Stimulation Differentially Modulate Primary Motor Cortex Excitability

Sasaki

Kotan

Nakagawa

et al. 2017

Front. Hum. Neurosci.

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Modulation of cortical excitability by sensory inputs is a critical component of sensorimotor integration. Sensory afferents, including muscle and joint afferents, to somatosensory cortex (S1) modulate primary motor cortex (M1) excitability, but the effects of muscle and joint afferents specifically activated by muscle contraction are unknown. We compared motor evoked potentials (MEPs) following median nerve stimulation (MNS) above and below the contraction threshold based on the persistence of M-waves. Peripheral nerve electrical stimulation (PES) conditions, including right MNS at the wrist at 110% motor threshold (MT; 110% MNS condition), right MNS at the index finger (sensory digit nerve stimulation [DNS]) with stimulus intensity approximately 110% MNS (DNS condition), and right MNS at the wrist at 90% MT (90% MNS condition) were applied. PES was administered in a 4 s ON and 6 s OFF cycle for 20 min at 30 Hz. In Experiment 1 (n = 15), MEPs were recorded from the right abductor pollicis brevis (APB) before (baseline) and after PES. In Experiment 2 (n = 15), M- and F-waves were recorded from the right APB. Stimulation at 110% MNS at the wrist evoking muscle contraction increased MEP amplitudes after PES compared with those at baseline, whereas DNS at the index finger and 90% MNS at the wrist not evoking muscle contraction decreased MEP amplitudes after PES. M- and F-waves, which reflect spinal cord or muscular and neuromuscular junctions, did not change following PES. These results suggest that muscle contraction and concomitant muscle/joint afferent inputs specifically enhance M1 excitability.

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Section: Discussionmentioning

confidence: 99%

Presence and Absence of Muscle Contraction Elicited by Peripheral Nerve Electrical Stimulation Differentially Modulate Primary Motor Cortex Excitability

Sasaki

Kotan

Nakagawa

et al. 2017

Front. Hum. Neurosci.

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“…While other iEEG studies have examined TBS-induced oscillatory changes, notably increasing theta band power 12,100 , the voltage effects of TBS and the dynamics of these neural responses within and across stimulation trains remain unexplored. This is critical as these features voltage changes after stimulationunderlie neuroplasticity studies in animal models [57][58][59][60] . Our results indicate the reliable quantification and temporal tracking of evoked response immediately following each high-frequency burst (TBS response).…”

Section: Discussionmentioning

confidence: 99%

Theta-burst direct electrical stimulation remodels human brain networks

Huang,

Zelmann,

Hadar

et al. 2024

Preprint

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Patterned brain stimulation is a powerful therapeutic approach for treating a wide range of brain disorders. In particular, theta-burst stimulation (TBS), characterized by rhythmic bursts of 3-8 Hz mirroring endogenous brain rhythms, is delivered by transcranial magnetic stimulation to improve cognitive functions and relieve symptoms of depression. However, the mechanism by which TBS alters underlying neural activity remains poorly understood. In 10 pre-surgical epilepsy participants undergoing intracranial monitoring, we investigated the neural effects of TBS. Employing intracranial EEG (iEEG) during direct electrical stimulation across 29 stimulation cortical locations, we observed that individual bursts of electrical TBS consistently evoked strong neural responses spanning broad cortical regions. These responses exhibited dynamic changes over the course of stimulation presentations including either increasing or decreasing voltage responses, suggestive of short-term plasticity in the amplitude of the local field potential voltage response. Notably, stronger stimulation augmented the mean amplitude and distribution of TBS responses , leading to greater proportion of recording sites demonstrating short-term plasticity. TBS responses were stimulation site-specific and propagated according to the underlying functional brain architecture, as stronger responses were observed in regions with strong baseline effective (cortico-cortical evoked potentials) and functional (low frequency phase locking) connectivity. Further, our findings enabled the predictions of locations where both TBS responses and change in these responses (e.g. short-term plasticity) were observed. Future work may focus on using pre-treatment connectivity alongside other biophysical factors to personalize stimulation parameters, thereby optimizing induction of neuroplasticity within disease-relevant brain networks.

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“…McKay et al (2002) measured changes in MEPs at 15 min intervals for up to 2 h of neuroelectrical stimulation in healthy participants, reporting that the MEP peaked 45−60 min after the first stimulus [24]. Saito et al also reported that there was no change in the MEP amplitude values before and after 20 min of paired-pulse electrical stimulation [25]. As the results of the present study are similar to those of previous ones, we believe that 20 min of PES stimulation is insufficient time when MEP is evaluated using the FDI muscle as the guiding muscle, and that stimulation for >40 min may increase the excitability of the primary motor cortex.…”

Section: Discussionmentioning

confidence: 99%

Difference between the Effects of Peripheral Sensory Nerve Electrical Stimulation on the Excitability of the Primary Motor Cortex: Examination of the Combinations of Stimulus Frequency and Duration

et al. 2022

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Peripheral sensory nerve electrical stimulation (PES) excites the primary motor cortex and is expected to improve motor dysfunction post-stroke. However, previous studies have reported a variety of stimulus frequencies and stimulus duration settings, and the effects of these different combinations on primary motor cortex excitability are not clear. We aimed to clarify the effects of different combinations of stimulus frequency and stimulus duration of PES on the excitation of primary motor cortex. Twenty-one healthy individuals (aged > 18 years, right-handed, and without a history of neurological or orthopedic disorders) were included. Each participant experienced three different stimulation frequencies (1, 10, and 50 Hz) and durations (20, 40, and 60 min). Motor-evoked potentials (MEPs) were recorded pre- and post-PES. The outcome measure was the change in primary motor cortex excitability using the MEP ratio. We used a D-optimal design of experiments and response surface analysis to define the optimal combination within nine different settings inducing more satisfying responses. The combination of stimulation frequency and stimulation time that maximized the desirability value was 10 Hz and 40 min, respectively. The results of this study may provide fundamental data for more minimally invasive and effective implementation of PES in patients with stroke.

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Effect of Paired-Pulse Electrical Stimulation on the Activity of Cortical Circuits

Cited by 6 publications

References 38 publications

Presence and Absence of Muscle Contraction Elicited by Peripheral Nerve Electrical Stimulation Differentially Modulate Primary Motor Cortex Excitability

Presence and Absence of Muscle Contraction Elicited by Peripheral Nerve Electrical Stimulation Differentially Modulate Primary Motor Cortex Excitability

Theta-burst direct electrical stimulation remodels human brain networks

Difference between the Effects of Peripheral Sensory Nerve Electrical Stimulation on the Excitability of the Primary Motor Cortex: Examination of the Combinations of Stimulus Frequency and Duration

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