Effect of ozone therapy on autogenous bone graft healing in calvarial defects: a histologic and histometric study in rats

Özdemir, Hakan; Toker, Hülya; Balcı, Halil İbrahim; Özer, Hatice

doi:10.1111/jre.12060

Cited by 56 publications

(54 citation statements)

References 33 publications

(49 reference statements)

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“…Ozone application was performed with a ozone genarator. They reported that ozone therapy increased osteoblast numbers and total bone area and bone formation in autogenous bone grafts in the rat calvarial defect model 20) . Erdemci et al 21) evaluated effect of the systemic and topical ozone administration on alveolar bone healing following tooth extraction in rats.…”

Section: Discussionmentioning

confidence: 99%

Effects of Gaseous Ozone Treatment on Bone Regeneration in Femoral Defect Model in Rats

Duman

Davul

Gökçe

et al. 2017

J. Hard Tissue Biology.

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The purpose of this study was to investigate the effect of ozone therapy in rat femoral fractures.Following the right open femoral fractures and intramedullary Kirschner wire fixation of the fracture in 60 male Wistar albino rats, the animals were divided into two groups of 30 animals each: ozone therapy group (n=30); non-treatment (control) group (n=30). Ozone was administered by rectal insufflation. After the rats were sacrified fracture healing was assessed by biomechanical and histopathologic evaluation. Histological and mechanical findings indicated that the ozone therapy had a significantly positive effect on bone healing.

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Section: Discussionmentioning

confidence: 99%

Effects of Gaseous Ozone Treatment on Bone Regeneration in Femoral Defect Model in Rats

Duman

Davul

Gökçe

et al. 2017

J. Hard Tissue Biology.

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“…Topical ozone therapy was continued for five days to improve knee infection. After 20 months of follow-up, the bone and soft tissues showed complete recovery, and the patient was able to walk (25 (31) showed that ozone therapy is effective in bone healing in animal models. In an experimental study from Turkey, the researchers evaluated the adjunctive therapeutic effects of hyperbaric oxygen and ozonized oxygen in 48 male Sprague-Dawley rats.…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 97%

The Effectiveness of Ozone Therapy in Chronic Osteomyelitis: A Randomized Controlled Clinical Trial

Nabi

Sedighinejad

Mirbolouk

et al. 2018

Arch Clin Infect Dis

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Background: Treatment of chronic osteomyelitis is complex and includes long-term management with antibiotics and debridement. Inadequate blood supply, underlying diseases, and deep involvement of the infected area can cause classic treatments to fail and lead to serious complications, such as limb amputation. Recently, there has been increasing interest in the use of ozone therapy for infectious diseases. Objectives: This study was designed to investigate the beneficial effects of ozone therapy on chronic osteomyelitis. Methods: Sixty patients with chronic osteomyelitis were divided into two homogenized groups: ozone therapy and control. Ozone therapy at a concentration of 30 mg/mL was performed daily by ozone bagging, minor autohemotherapy, and ozone saline injection into the bone. Data were analyzed to determine recovery and erythrocyte sedimentation rates. Results: The recovery rate was 73.33% in the control group versus 86.66% in the ozone group (P = 0.31). No significant difference was found between the groups regarding the recovery rate (P = 0.86). However, considering the erythrocyte sedimentation rate, the results were significantly superior in the ozone group (P = 0.0001). Conclusions: These findings indicate that ozone therapy, as a promising complementary treatment, can be applied in chronic osteomyelitis management.

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“…They concluded that postoperative long-term systemic ozone application can accelerate alveolar bone healing following extraction [38]. Ozdemir H, et al evaluated the effect of ozone therapy on autogenous bone graft in calvarial defects [39]. They concluded that ozone therapy provided to new bone formation with an autogenous bone graft in the rat calvarial defect model.…”

Section: Discussionmentioning

confidence: 99%

Application of Ozone Nanobubble Water (ONBW) to Peri-Implantitis Treatment

Arakawa¹,

Mitsuru²,

Leewananthawet³

2017

Dentistry

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In this case report, we investigated the effects of Ozone nanobubble water (ONBW) on peri-implantitis lesions with non-surgical treatment. ONBW preserves the ozone gas nucleus for more than 6 months although half life time of ozone water was almost 30 minutes. ONBW exerts anti-microbial activity towards several kinds of bacteria including periodontopathic bacteria and cariogenic bacteria. There was no cytotoxicity against oral epithelial and mucosa cells. The Advanced quick bonding (AQB) implants on 19 and 20 were placed on a patient 43 years old female four years ago. The chief complaint of her was swelling at the site of 20. The patient presented swollen at peri-implant area, Bleeding of probing (BOP), and probing depth (PD)=6 mm at buccal site of an implant of 20. There was no findings of mobility at concerned implant. The bone resorption and a radiolucent part around the implant was confirmed with periapical radiograph. The amount of bone loss was 5.0 and 6.5mm at mesial and distal site of 20, respectively. This peri-implantitis was evaluated the case required surgical therapy. In addition to mechanical plaque control, the patient received regular professional oral hygiene treatment and irrigation with ONBW every week at 100mL each. And also, regarding chemical plaque control, the irrigation for pockets was also performed at home by the patient at a frequency of three times a day every day. After 12 weeks, soft tissues of the peri-implant presented no clinical signs of inflammation and BOP, and PD was 3 mm. The bone levels did not change significantly as demonstrated by the follow-up roentgenography taken after 3 years. Microbiologically, the number of red-complex of periodontopathic bacteria have been decreased substantially. This case report supports that ONBW might be effective and predictable as an adjunctive therapy for peri-implantitis. To the best our knowledge, this is the first report on describing the peri-implantitis treatment with ONBW.

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Effect of ozone therapy on autogenous bone graft healing in calvarial defects: a histologic and histometric study in rats

Abstract: Ozone therapy enhances new bone formation by autogenous bone graft in the rat calvarial defect model.

Cited by 56 publications

References 33 publications

Effects of Gaseous Ozone Treatment on Bone Regeneration in Femoral Defect Model in Rats

Effects of Gaseous Ozone Treatment on Bone Regeneration in Femoral Defect Model in Rats

The Effectiveness of Ozone Therapy in Chronic Osteomyelitis: A Randomized Controlled Clinical Trial

Application of Ozone Nanobubble Water (ONBW) to Peri-Implantitis Treatment

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