Effect of oxytocin nasal spray on auditory automatic discrimination measured by mismatch negativity

Ochiai, Haruka; Shiga, Tetsuya; Hoshino, Hiroshi; Horikoshi, Sho; Kanno, Ken‐ichiro; Wada, Tomohiro; Osakabe, Yusuke; Miura, Itaru

doi:10.1007/s00213-021-05807-w

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…OT enables pup retrieval behavior in female mice by enhancing auditory cortical pup call responses through fine-tunes excitatory and inhibitory responses in the left cortex of maternal adults ( Marlin et al, 2015 ). IAO can shorten latency but not amplitude of mismatch negativity, an event-related potential reflecting auditory discrimination in humans ( Ochiai et al, 2021 ), suggesting that OT may promote the comparison-decision stage. Thus, OT can modulate the activity of auditory system at multiple levels, particularly at higher brain centers.…”

Section: Regulation Of Sensorimotor Activitymentioning

confidence: 99%

Neural Functions of Hypothalamic Oxytocin and its Regulation

Wang

Liu

et al. 2022

ASN Neuro

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Oxytocin (OT), a nonapeptide, has a variety of functions. Despite extensive studies on OT over past decades, our understanding of its neural functions and their regulation remains incomplete. OT is mainly produced in OT neurons in the supraoptic nucleus (SON), paraventricular nucleus (PVN) and accessory nuclei between the SON and PVN. OT exerts neuromodulatory effects in the brain and spinal cord. While magnocellular OT neurons in the SON and PVN mainly innervate the pituitary and forebrain regions, and parvocellular OT neurons in the PVN innervate brainstem and spinal cord, the two sets of OT neurons have close interactions histologically and functionally. OT expression occurs at early life to promote mental and physical development, while its subsequent decrease in expression in later life stage accompanies aging and diseases. Adaptive changes in this OT system, however, take place under different conditions and upon the maturation of OT release machinery. OT can modulate social recognition and behaviors, learning and memory, emotion, reward, and other higher brain functions. OT also regulates eating and drinking, sleep and wakefulness, nociception and analgesia, sexual behavior, parturition, lactation and other instinctive behaviors. OT regulates the autonomic nervous system, and somatic and specialized senses. Notably, OT can have different modulatory effects on the same function under different conditions. Such divergence may derive from different neural connections, OT receptor gene dimorphism and methylation, and complex interactions with other hormones. In this review, brain functions of OT and their underlying neural mechanisms as well as the perspectives of their clinical usage are presented.

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Section: Regulation Of Sensorimotor Activitymentioning

confidence: 99%

Neural Functions of Hypothalamic Oxytocin and its Regulation

Wang

Liu

et al. 2022

ASN Neuro

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“…The results of this study are significant because cognitive functioning may affect employment functioning, social functioning and driving (van der Sluiszen et al ., 2017). A recent study reported that benzodiazepine but not orexin receptor antagonists attenuated mismatch negativity in healthy subjects(Ochiai et al ., 2021). Although the results showed that different cognitive domains improved in each case, the mechanism in this regard is not clear.…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of switching from benzodiazepine to orexin receptor antagonists improves cognitive function in psychiatric disorders: four case reports

Hori¹

2022

International Clinical Psychopharmacology

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Benzodiazepines are used in the treatmentof anxiety and insomnia. On the other hand, they not only have side effects such as drowsiness, poor concentration, and muscle relaxation but also persistent cognitive decline. Even if we try to reduce the dose of these drugs to improve drug-induced cognitive function, it is difficult to do so due to dependence and worsening insomnia. I report four cases in which cognitive dysfunction was improved by switching from benzodiazepines to orexin receptor antagonists (suvorexant and lemborexant ). Orexin receptor antagonists were effective to improve cognitive impairment. In cognitive dysfunction caused by benzodiazepines, switching to orexin receptor antagonists may be effective.

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“…MMN is accessible with neuroscientific methods other than EEG such as MEG, fMRI, NIRS, PET, human intracranial recordings ( Näätänen, 1992 ), or animal in vivo whole-cell patch-clamp recordings ( Valdés-Baizabal et al, 2021 ). It has been described for other modalities such as vision ( Kimura, 2012 ; Stefanics et al, 2014 ; Czigler and Kojouharova, 2021 ), and even somatosensation ( Butler et al, 2011 ; Strömmer et al, 2014 ) and smell ( Ochiai et al, 2021 ). It is generated in the respective sensory cortices, but generators in frontal brain areas may also be involved ( Näätänen and Alho, 1995 ; Escera and Malmierca, 2014 ; Carbajal and Malmierca, 2018 ).…”

Section: Mismatch Negativitymentioning

confidence: 99%

Markov chains as a proxy for the predictive memory representations underlying mismatch negativity

Schröger,

Roeber,

Coy

2023

Front. Hum. Neurosci.

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Events not conforming to a regularity inherent to a sequence of events elicit prediction error signals of the brain such as the Mismatch Negativity (MMN) and impair behavioral task performance. Events conforming to a regularity lead to attenuation of brain activity such as stimulus-specific adaptation (SSA) and behavioral benefits. Such findings are usually explained by theories stating that the information processing system predicts the forthcoming event of the sequence via detected sequential regularities. A mathematical model that is widely used to describe, to analyze and to generate event sequences are Markov chains: They contain a set of possible events and a set of probabilities for transitions between these events (transition matrix) that allow to predict the next event on the basis of the current event and the transition probabilities. The accuracy of such a prediction depends on the distribution of the transition probabilities. We argue that Markov chains also have useful applications when studying cognitive brain functions. The transition matrix can be regarded as a proxy for generative memory representations that the brain uses to predict the next event. We assume that detected regularities in a sequence of events correspond to (a subset of) the entries in the transition matrix. We apply this idea to the Mismatch Negativity (MMN) research and examine three types of MMN paradigms: classical oddball paradigms emphasizing sound probabilities, between-sound regularity paradigms manipulating transition probabilities between adjacent sounds, and action-sound coupling paradigms in which sounds are associated with actions and their intended effects. We show that the Markovian view on MMN yields theoretically relevant insights into the brain processes underlying MMN and stimulates experimental designs to study the brain’s processing of event sequences.

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Effect of oxytocin nasal spray on auditory automatic discrimination measured by mismatch negativity

Cited by 4 publications

References 32 publications

Neural Functions of Hypothalamic Oxytocin and its Regulation

Neural Functions of Hypothalamic Oxytocin and its Regulation

Successful treatment of switching from benzodiazepine to orexin receptor antagonists improves cognitive function in psychiatric disorders: four case reports

Markov chains as a proxy for the predictive memory representations underlying mismatch negativity

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