Effect of Oxygen Releasing Oral Gel Compared to Chlorhexidine Gel in the Treatment of Periodontitis

Abstract

The aim of the current study is to compare the effect of oxygen releasing oral gel and chlorhexidine gel in the treatment of periodontitis and the objective was to assess and compare the changes in clinical parameters such as Probing pocket depth, Bleeding on probing, Clinical attachment levels between oxygen releasing oral gel and chlorhexidine gel.
 The current pilot study which compares oxygen releasing gel with chlorhexidine gel is a randomised split mouth clinical trial .All the patients included in the study were patients with moderate to severe periodontitis with no systemic diseases, not under any medication non smoking healthy patients. All the patients received supra and sub gingival scaling, pockets on molars with deeper probing depth on either maxillary or mandibular arch and the medication to be received by the patient were allotted randomly. Randomisation was performed using lot method.Oxygen releasing (Blue M gel) and chlorhexidine gel (Hexigel) was applied at the chosen site, patient was recalled for re application and was reassessed for clinical parameters Paired t test was done to compare the mean difference in probing depth in Blue M gel group and Hexigel group.
 The mean probing depth at the day of drug delivery was for Blue M gel group was 7.2 mm SD+/-0.42 mm and the mean probing depth six week after drug delivery was 4.7 SD+/- 0.57 mm with a significant p value of 0.42. The mean probing depth at the day of drug delivery was for Hexigel gel group was 7.0 mm SD+/-0.57 mm and the mean probing depth six week after drug delivery was 5.7 SD+/- 0.64 mm.
 Within the limitations of the study from the results it is seen that there is a significant difference in reduction in probing pocket depth. The mean difference between the probing depth reduction in group A (Blue M ) from baseline to 6 week was 2.3 and The mean difference probing depth reduction in group B (Hexigel ) from baseline to 6 week was 1.5. Group A showed better potential in probing depth reduction. It emphasises the fact that thorough sub gingival scaling and root planing along with adjuvant topical oxygen therapy aid in reducing the periodontal pockets further research has to be done to assess the effect of oxygen delivering agents in future.

Topical oxygen therapy as a novel strategy to promote wound healing and control the bacteria in implantology, oral surgery and periodontology: A review

“…Studies have demonstrated a significant shift in microbial composition toward a homeostasis state of biofilm after applying oxygen therapy ( Fernandez, 2014 , Filoche et al, 2010 , Fernandez y Mostajo, M., Exterkate, R.A., Buijs, M.J., Crielaard, W., Zaura, E., , 2017 ). Niveda and Kaarthikeyan reported a significant reduction in probing pocket depth in patients with chronic periodontitis treated with blue®m oxygen therapy, confirming its clinical advantage on periodontitis ( Niveda, and Kaarthikeyan, 2020 ). Toothpastes containing active oxygen and lactoferrin have been proven to have comparable antiplaque and antigingivitis efficacies compared to triclosan-containing toothpastes ( Cunha et al, 2019 ).…”

Treatment of Medication-Related Osteonecrosis of the Jaws (MRONJ) with Topical Therapy Using Active Oxygen Gel

“…The group treated with oxygen-releasing gel showed better potential for reducing the probing depth. 9 When used to treat periodontitis, active oxygen in gel form selectively eradicates the anaerobic bacteria associated with the condition, promoting the recovery of healthy oral flora. 10 This clinical result corroborates the findings of the in vitro study, which showed that blue ® m oral gel reduced a smaller number of bacterial species when compared to chlorhexidine during subgingival biofilm formation, but it was better than chlorhexidine in reducing red-complex bacterial proportions.…”

A Narrative Review on Means to Promote Oxygenation and Angiogenesis in Oral Wound Healing

“…The group that was treated with the oxygen-releasing oral gel showed better potential in probing depth reduction. The authors emphasized that thorough sub-gingival scaling and root planning, along with adjuvant tOT, aid in reducing periodontal pockets [ 80 ]. Active oxygen in a gel form used for the treatment of periodontitis selectively eradicates the anaerobic bacteria associated with periodontitis to promote the recovery of a health-compatible oral flora [ 81 ].…”