Effect of oxygen on sleep quality, cognitive function and sympathetic activity in patients with chronic heart failure and Cheyne–Stokes respiration

Staniforth, Andrew; Kinnear, William; Starling, Randall; Hetmanski, David J.; Cowley, A. J.

doi:10.1053/euhj.1997.0861

Cited by 199 publications

(137 citation statements)

References 23 publications

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“…Nocturnal supplemental O 2 has been shown to abolish apnea-related hypoxia, to alleviate CSA, to decrease nocturnal norepinephrine levels over periods of 1 night to 1 month, 291,358,359 and to increase maximum O 2 uptake during a graded exercise test. 360 However, when administered for 1 month, O 2 had no impact on cardiac function or quality of life.…”

Section: Treatment Options In Csamentioning

confidence: 99%

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Sleep Apnea and Cardiovascular Disease

et al. 2008

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Section: Treatment Options In Csamentioning

confidence: 99%

“…360 However, when administered for 1 month, O 2 had no impact on cardiac function or quality of life. 359 Long-term effects on cardiovascular end points have not been evaluated.…”

Section: Treatment Options In Csamentioning

confidence: 99%

Sleep Apnea and Cardiovascular Disease

et al. 2008

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“…Nocturnal oxygen (O 2 ) supplementation has been shown to abolish apnea-related hypoxia, alleviate CSA, decrease nocturnal norepinephrine levels over periods of one night to one month, and then improve left ventricular (LV) function and exercise tolerance (Hanly et al 1989;Sasayama et al 2006). However, it is also known that some non-responders to O 2 therapy exist (Staniforth et al 1998;Javaheri et al 1999). In this study, we thus aimed to elucidate predictor(s) for responders to the O 2 therapy in CHF patients with CSA.…”

Section: Introductionmentioning

confidence: 99%

End-Tidal CO<sub>2</sub> Tension Is Predictive of Effective Nocturnal Oxygen Therapy in Patients with Chronic Heart Failure and Central Sleep Apnea

Sugimura

Shinozaki

Fukui

et al. 2016

Tohoku J. Exp. Med.

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Central sleep apnea (CSA) is characterized by recurring cycles of crescendo-decrescendo ventilation during sleep, and enhances sympathetic nerve activity. Thus CSA has a prognostic impact in patients with chronic heart failure (CHF). Although nocturnal oxygen (O 2 ) therapy decreases frequency of CSA and improves functional exercise capacity, it is also known that some non-responders to the therapy exist. We thus aimed to identify predictors of responders to nocturnal O 2 therapy in CHF patients with CSA. In 12 CHF patients with CSA hospitalized at our department, sleep study was performed at 2 consecutive nights. Patients nasally inhaled O 2 at either the first or second night in a randomized manner. To predict the percentage reduction in apnea-hypopnea index (%ΔAHI) in response to the nocturnal O 2 therapy, we performed multiple regression analysis with a stepwise method with variables including age, brainnatriuretic peptide, circulation time, baseline AHI, hypercapnic ventilatory response and end-tidal carbon dioxide tension (P ET CO 2 ). Nocturnal O 2 therapy significantly decreased AHI (from 32 ± 13 /h to 12 ± 10 /h, P < 0.0001). Among the possible predictors, P ET CO 2 was the only variable that is predictive of % changes in AHI. Receiver operating characteristics analysis determined 4.25% as the optimal cutoff P ET CO 2 level to identify responder to nocturnal O 2 therapy (> 50% reduction of AHI), with 88.9% of sensitivity and 66.7% of specificity. In conclusion, P ET CO 2 is useful to predict the efficacy of O 2 therapy in CHF patients with CSA, providing important information to the current nocturnal O 2 therapy.

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“…Oxygen therapy has been shown to improve left ventricular ejection fraction and exercise capacity and to reduce sympathetic activity in patients with Cheyne-Stokes respiration [12][13][14]. Adaptive servo-ventilation effectively reduced central apnoea during Cheyne-Stokes respiration [15] and reduced daytime sleepiness in one study [16].…”

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confidence: 99%