Effect of oxygen on neuronal excitability measured by critical flicker fusion frequency is dose dependent

Kot, Jacek; Winklewski, Paweł J.; Sićko, Zdzisław; Tkachenko, Yurii

doi:10.1080/13803395.2015.1007118

Cited by 16 publications

(23 citation statements)

References 39 publications

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“…Several reports have demonstrated that short-term normobaric oxygen (NBO) (maximum 1.0 ATA O2) positively influenced cognitive abilities, such as memory, visuospatial and verbal abilities (Moss and Scholey 1996;Moss et al 1998;Scholey et al 1998Scholey et al , 1999Chung et al 2006) and functional magnetic resonance (fMRI) studies have demonstrated that normobaric hyperoxia (NBO, 0.3 ATA O2) during verbal or visual tasks increases the activation of brain areas associated with cognitive processing (Choi et al 2010). Kot et al (2015) examined the effect of oxygen on neuronal excitability using CFFF in a hyperbaric environment and demonstrated a dosedependent effect. These authors concluded that neuronal excitability and oxygen poisoning transduction pathways were intertwined.…”

Section: Oxygenmentioning

confidence: 99%

Inert gas narcosis in scuba diving, different gases different reactions

et al. 2018

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Purpose Underwater divers face several potential neurological hazards when breathing compressed gas mixtures including nitrogen narcosis which can impact diver's safety. Various human studies have clearly demonstrated brain impairment due to nitrogen narcosis in divers at 4 ATA using critical flicker fusion frequency (CFFF) as a cortical performance indicator. However, recently some authors have proposed a probable adaptive phenomenon during repetitive exposure to high nitrogen pressure in rats, where they found a reversal effect on dopamine release. Methods Sixty experienced divers breathing Air, Trimix or Heliox, were studied during an open water dive to a depth of 6 ATA with a square profile testing CFFF measurement before (T 0 ), during the dive upon arriving at the bottom (6 ATA) (T 1 ), 20 min of bottom time (T 2 ), and at 5 m (1.5 ATA) (T 3 ). Results CFFF results showed a slight increase in alertness and arousal during the deep dive regardless of the gas mixture breathed. The percent change in CFFF values at T 1 and T 2 differed among the three groups being lower in the air group than in the other groups. All CFFF values returned to basal values 5 min before the final ascent at 5 m (T 3 ), but the Trimix measurements were still slightly better than those at T 0 . Conclusions Our results highlight that nitrogen and oxygen alone and in combination can produce neuronal excitability or depression in a dose-related response. Keywords Nitrogen narcosis • Divers' safety • Critical flicker fusion frequency • GABA receptors Abbreviations ATA Atmospheres of pressure absolute 1 ATA = 1.01325 bar, 760 mmHg, 10 m H 2 O CFFF Critical flicker fusion frequency DCS Decompression sickness EAN Enriched air nitrox GABA receptors Gamma aminobutyric acid receptors HELIOX Helium and oxygen HPNS High pressure nervous syndrome TRIMIX Mixture of nitrogen, helium and oxygen Communicated by Jean-René Lacour.

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Section: Oxygenmentioning

confidence: 99%

Inert gas narcosis in scuba diving, different gases different reactions

et al. 2018

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“…According to one study, the effects on neuronal excitability measured by CFFF of changes in PO 2 could be dosedependent. 34 Oxygen at 93 kPa resulted in partial recovery of motor and memory reaction times in some hyperbaric conditions while caused incapacitation with amnesia in others. 35 In this latter study, even high PN 2 (up to 0.57 MPa) was well tolerated providing neither hypercapnia nor hyperoxia were present.…”

Section: F O R P E R S O N a L U S E O N L Ymentioning

confidence: 99%

Early detection of diving-related cognitive impairment of different nitrogen-oxygen gas mixtures using critical flicker fusion frequency

Lafère¹,

Hemelryck

Germonpré³

et al. 2019

Diving Hyperb Med

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Introduction: Cognitive impairment related to inert gas narcosis (IGN) is a threat to diving safety and operations at depth that might be reduced by using enriched air nitrox (EANx) mixtures. Using critical flicker fusion frequency (CFFF), a possible early detection of cognitive abilities/cerebral arousal impairment when breathing different oxygen (O 2) fractions was investigated. Methods: Eight male volunteers performed, in random order, two dry chamber dives breathing either air or EANx40 (40% O 2 −60% nitrogen) for 20 minutes (min) at 0.4 MPa. Cognition and arousal were assessed before the dive; upon arrival at 0.4 MPa; after 15 min exposure at 0.4 MPa; on surfacing and 30 min post-dive using behavioural computer-based testing psychology experiment building language (PEBL) and by CFFF while continuously recording brain oxygenation with near-infrared spectroscopy. Results: In both breathing conditions, CFFF and PEBL demonstrated a significant inverse correlation (Pearson r of-0.90, P < 0.0001), improved cognitive abilities/cerebral arousal occurred upon arrival at 0.4 MPa followed by a progressive deterioration. Initial brain activation was associated with a significant increase in oxyhaemoglobin (HbO 2) and a simultaneous decrease of deoxyhaemoglobin (HHb). The magnitude of the changes was significantly greater under EANx (P = 0.038). Conclusions: Since changes were not related to haemodynamic variables, HbO 2 and HHb values indicate a significant, O 2-dependent activation in the prefrontal cortex. Owing to the correlation with some tests from the PEBL, CFFF could be a convenient measure of cognitive performance/ability in extreme environments, likely under the direct influence of oxygen partial pressure, a potent modulator of IGN symptoms.

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“…The boundary between the positive and negative effects of ROS is still unclear, as oxygen metabolism in cells often induces both physiological and pathological consequences, by using intertwined transduction cellular pathways. 13 This review provides an account of the ROS studies undertaken so far in order to provide a clearer understanding. To this end, we discuss the relationship between ROS and plasticity, exposing the main cellular mechanisms responsible for pathological and physiological processes.…”

Section: Introductionmentioning

confidence: 99%

Reactive Oxygen Species: Physiological and Physiopathological Effects on Synaptic Plasticity

2016

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In the mammalian central nervous system, reactive oxygen species (ROS) generation is counterbalanced by antioxidant defenses. When large amounts of ROS accumulate, antioxidant mechanisms become overwhelmed and oxidative cellular stress may occur. Therefore, ROS are typically characterized as toxic molecules, oxidizing membrane lipids, changing the conformation of proteins, damaging nucleic acids, and causing deficits in synaptic plasticity. High ROS concentrations are associated with a decline in cognitive functions, as observed in some neurodegenerative disorders and age-dependent decay of neuroplasticity. Nevertheless, controlled ROS production provides the optimal redox state for the activation of transductional pathways involved in synaptic changes. Since ROS may regulate neuronal activity and elicit negative effects at the same time, the distinction between beneficial and deleterious consequences is unclear. In this regard, this review assesses current research and describes the main sources of ROS in neurons, specifying their involvement in synaptic plasticity and distinguishing between physiological and pathological processes implicated.

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Effect of oxygen on neuronal excitability measured by critical flicker fusion frequency is dose dependent

Cited by 16 publications

References 39 publications

Inert gas narcosis in scuba diving, different gases different reactions

Inert gas narcosis in scuba diving, different gases different reactions

Early detection of diving-related cognitive impairment of different nitrogen-oxygen gas mixtures using critical flicker fusion frequency

Reactive Oxygen Species: Physiological and Physiopathological Effects on Synaptic Plasticity

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