Effect of Oxprenolol on Stage-Fright in Musicians

Im, James; Griffith, D.N.W.; Pearson, Richard M.; Newbury, Patricia

doi:10.1016/s0140-6736(77)90890-x

Cited by 133 publications

(39 citation statements)

References 5 publications

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“…Although oxprenolol, in similar doses of those we have used, has been shown to be anxiolytic in previous work, this effect was in situations in which sympathetic (primarily somatic) reactions to anxiety were prominent. For example, 'stage-fright' in musicians (James et al, 1977) or public speaking (Taggart et al, 1973). The apparent lack of effect in this study may be due to the absence of excessive peripheral sympathetic responses to anxiety ih the normal individuals we have tested.…”

Section: Discussionmentioning

confidence: 62%

The effects of diazepam and oxprenolol on short term memory in individuals of high and low state anxiety.

Desai¹,

Taylor-Davies²,

Barnett³

1983

Brit J Clinical Pharma

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1 The effect of oral doses of diazepam (5 mg) and oxprenolol (80 mg) on short term memory of normal individuals stratified for 'state' anxiety levels has been investigated. 2 Normal student volunteers were stratified into high and low anxiety groups on the basis of responses to the Spielberger 'A-state' scale. Subjects were then randomly administered active drug or placebo and given a form of running memory test performed under a variety of conditions in which variable rate of item presentation and articulatory suppression were used.3 Diazepam significantly reduced the errors of recall in the running memory test in the high anxiety group and produced a distinct separation of response from the low anxiety group under the test conditions of slow item presentation with articulatory suppression. Oxprenolol had no effect on the short term memory test in either high or low anxiety groups in any experimental test situation. 4 These results are compared to previous work in which generally a deleterious effect of diazepam on short term memory in normal volunteers has been reported. The implications of these findings are further discussed in relationship to possible models of memory function.

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Section: Discussionmentioning

confidence: 62%

The effects of diazepam and oxprenolol on short term memory in individuals of high and low state anxiety.

Desai¹,

Taylor-Davies²,

Barnett³

1983

Brit J Clinical Pharma

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“…James et al (1977) also found this treatment to ameliorate the subjects' self-ratings. It is clear that enhanced sympathetic activity will be detrimental to performance in tests requiring a steady hand and complex motor coordination (as in a musical performance).…”

Section: Pulsementioning

confidence: 80%

A comparison of the effects of lorazepam with those of propranolol on experimentally‐induced anxiety and performance.

File¹,

Lister²

1985

Brit J Clinical Pharma

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1 In a double-blind cross-over study the effects of propranolol (80 mg) and of lorazepam (1 or 2.5 mg) were assessed in normal student volunteers using a number of performance tests and mood-rating and bodily symptom questionnaires. Drug effects on experimentally-induced anxiety were also studied. 2 The high dose of lorazepam impaired performance in digit-symbol substitution, symbol copying and verbal learning tests, and increased subjects' ratings of dizziness. Both lorazepam and propranolol increased simple reaction time. Lorazepam but not propranolol increased ratings of sedation. 3 Although the stressor increased subjects' ratings of anxiety, neither drug altered anxiety ratings. 4 Propranolol decreased and lorazepam increased subjects' pulse. These changes were not reflected in subjects' self-ratings -lorazepam caused a reduction in ratings of palpitations. 5 The results suggest that if administered acutely, neither drug is beneficial in the treatment of short-term anxiety associated with intellectual stress.

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“…This increase in plasma adrenaline concentration was not observed after the climbs following oxprenolol, and again there was no significant difference in plasma noradrenaline concentrations (Table 11). (Taggart, Carruthers, et al, 1973) and the effect of using a beta-adrenoceptorblocking drug in such circumstances has been investigated (James, Pearson, et al, 1977). It is the general concensus of opinion amongst climbers that rock climbing (as contrasted with mountaineering) entails a strong element of anxiety together with a considerable but by no means intense element of physical exertion.…”

Section: Discussionmentioning

confidence: 99%

Rock climbing: observations on heart rate and plasma catecholamine concentrations and the influence of oxprenolol.

Williams¹,

Taggart²,

Carruthers³

1978

Br J Sports Med

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Observations are presented on the electrocardiogram and plasma catecholamine concentrations of 11 healthy men monitored during two rock climbing ascents. A placebo was administered prior to the first climb and an oral dose of the beta blocking agent oxprenolol ("Trasicor") prior to the second. Mean heart rates were 166 (± 20.4 SD) and 120 (+ 10.2) respectively. Median plasma adrenaline concentrations were 0.05 ,ug/1 and 0.33 gg/1 before and after the climbs following the placebo. No significant difference was observed in the adrenaline concentrations before and after climbing following oxprenolol, or of noradrenaline concentrations on either occasion.These results are interpreted as suggesting that this popular sport represents more an anxiety-type of psychological stress than a physical stress and as such is likely to increase moral fibre rather than muscle fibre. INTRODUCTI ON METHODSIncreasing affluence and leisure has swelled the ranks of those who partake in recreation requiring physical fitness greater than that demanded by their work. The modern epidemic of coronary artery disease has also focussed attention upon the desirability of 'keeping fit' (Turner and Ball, 1973 It is therefore appropriate to consider whether this form of exercise is likely to be useful in securing the increasingly sought-after benefits of regular physical exertion which have been reveiwed at length by Astrand and Rodahl (1970). Alternatively, is rock climbing one means, among others, of producing the psychological fitness assuring the climber that he possesses the necessary skill, strength, endurance and experience to complete his chosen climb? (Edwards 1975). SubjectsEleven men who were either members of the police force undergoing arduous training or professional climbing instructors with apparently normal hearts (the police had been medically examined and the instructors' occupation was assumed to preclude cardiac abnormality) volunteered to participate in the study. Their mean age was 31 (range 24-48) and experience varied from novice to professional. ProcedureEach subject undertook two climbs, the first in the morning and the second in the afternoon, the whole study being completed in the course of a single day. A single blind technique was used, each subject being given a placebo tablet one hour prior to his climb in the morning and an oral dose of the beta-blocking agent oxprenolol one hour before his second climb in the afternoon.The climbs which were conducted on the sandstone cliff Bowles Rocks near Tunbridge Wells were so chosen that they were of comparable difficulty for each of the subjects' first and second ascents. Different routes were 125

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Effect of Oxprenolol on Stage-Fright in Musicians

Cited by 133 publications

References 5 publications

The effects of diazepam and oxprenolol on short term memory in individuals of high and low state anxiety.

The effects of diazepam and oxprenolol on short term memory in individuals of high and low state anxiety.

A comparison of the effects of lorazepam with those of propranolol on experimentally‐induced anxiety and performance.

Rock climbing: observations on heart rate and plasma catecholamine concentrations and the influence of oxprenolol.

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