Effect of oxiplex∗ films (PEO/CMC) on adhesion formation and reformation in rabbit models and on peritoneal infection in a rat model

Rodgers, Kathleen E.; Schwartz, H. E.; Roda, Norma; Thornton, Melvin H.; Kobak, William; diZerega, Gere S.

doi:10.1016/s0015-0282(99)00642-1

Cited by 53 publications

(33 citation statements)

References 20 publications

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“…This modification prolongs the permanence of the product in the body because carboxymethil cellulose is otherwise rapidly resorbed 19,24 . Previous studies using Oxiplex have shown a significant reduction in the degree of postoperative peridural fibrosis 32 . In our study reabsorption of Oxiplex was observed during 4 weeks.…”

Section: Discussionmentioning

confidence: 95%

“…Different studies relating to the anti-scar effects of Oxiplex have been performed in the fields of gynecology 37 , general surgery 31 , cardiovasculary surgery 5 , and neurosurgery 32 . The main purpose of clinical trials was testing the properties of this material as a mechanical barrier that prevents the fibrosis formation and the pain associated with it.…”

Section: Introductionmentioning

confidence: 99%

“…Several materials have been tested as barriers to reduce the extent of peridural fibrosis [10][11][12][13]15,25,27,32,33 . None of the barrier materials have been universally accepted for this use 1 .…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Oxiplex and Gore-Tex effectivity in an experimental peridural fibrosis model

et al. 2009

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SummaryObjective. The authors conducted a study to compare the effectiveness of Oxiplex and Gore-tex in preventing postlaminectomy peridural fibrosis in rats. Peridural fibrosis is a common cause of pain in patients undergoing spinal surgery. To prevent scar formation numerous materials and methods have been employed such as non steroidal anti-inflammatory drugs (NSAIDs), Gelfoam, Oxiplex, Gore-tex, carboxymethil cellulose, Adcon-L, autogenous adipose grefting, mitomisin, and radiotherapy have been investigating for a long time, but only moderate success has been obtained.Methods. Laminectomies were performed at the fourth lumbar vertebra (L-4) in 30 rats. Oxiplex or Gore-Tex was applied over the dura mater with the aim to perform a blinded evaluation of their effects. In the control group, only a L-4 laminectomy was performed. Animals were sacrificed 28 days after the surgical procedure. The extent of peridural fibrosis was evaluated on spine specimens by histological analysis.Results. Both groups of animals treated with either Oxiplex or Gore-Tex showed a significant reduction in the degree of peridural fibrosis as compared to the control group. However no significant difference in the prevention of peridural fibrosis was observed between the Oxiplex and Gore-Tex groups.Conclusions. This experimental model has shown that Oxiplex and Gore-Tex are effective methods to prevent peridural fibrosis and dural adhesions at the postlaminectomy areas.KEY WORDS: Peridural fibrosis. Oxiplex. Gore-Tex. Failed back syndrome.Comparación entre la eficacia del Oxiplex y del GoreTex en un modelo experimental de fibrosis peridural ResumenObjetivo. Los autores realizaron un estudio para comparar la eficacia de Oxiplex y Gore-tex en la prevención de fibrosis peridural tras laminectomías en ratas. La fibrosis peridural es una causa común de dolor en pacientes sometidos a cirugía de la columna vertebral. Para evitar la formación de cicatriz, se han empleado numerosos materiales y métodos como los antiinflamatorios no esteroideos (AINE), Gelfoam, Oxiplex, Gore-tex, carboxymethil celulosa, Adcon-L, injertos de grasa antóloga, mitomicina o la radioterapia, pero sólo se ha obtenido resultados exitosos en pocas ocasiones.Métodos. Se realizaron laminectomías en la cuarta vértebra lumbar (L-4) en 30 ratas. Se aplicaron Oxiplex o Gore-Tex sobre la duramadre con el objetivo de realizar una evaluación ciega de sus efectos. En el grupo control, sólo se realizó la laminectomía L4. Los animales fueron sacrificados 28 días después de la intervención quirúrgica. El grado de fibrosis peridural se evaluó sobre la columna vertebral de especímenes por análisis histológico.Resultados. Ambos grupos de animales tratados con Oxiplex o Gore-Tex mostraron una reducción significativa en el grado de fibrosis peridural en comparación con el grupo control. Sin embargo, ninguna diferencia significativa en la prevención de la fibrosis peridural se observó entre los grupos de Oxiplex y Gore-Tex.Conclusiones. Este modelo experimental ha demostrado que Oxiplex y Gor...

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Comparison of Oxiplex and Gore-Tex effectivity in an experimental peridural fibrosis model

et al. 2009

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“…MOREIRA et al (16) verificaram que, apesar da introdução do ácido hialurônico combinado com a CMC na cavidade peritonial, ocorreram aderências e abscessos em coelhos após enterotomia, mas não houve aumento da mortalidade por sepse. Recentemente, constatou-se que a associação de óxido de polietileno e CMC (Oxiplex) diminui de fato a formação de aderências, porém não afeta a resistência de ratos à infecção peritonial (25) . Já a maioria dos estudos verificou que a CMC é efetiva contra a formação de aderências apenas em condições assépticas (8,9,13,15,17,18,22,26,27,28,33) .…”

Section: Discussionunclassified

Inibição da formação de abscesso abdominal em rato: mortalidade por sepse

Rodrigues¹,

Carneiro²,

Rocha³

et al. 2005

Arq. Gastroenterol.

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“…One trade name is Oxiplex/SP gel, which, in an experimental study in rabbits, reduced epidural fibrosis and did not impair normal healing [8] . Both components of Oxiplex/SP gel (CMC and PEO) are known to reduce adhesion formation and fibrotic scars that form after surgery [46] . Kim et al have demonstrated a reduction and lower-extremity weakness over a 6-month follow-up period in patients that underwent discectomy [47] .…”

Section: Carboxymethylcellulosementioning

confidence: 99%

Prevention of failed back surgery syndrome with applications of different pharmacological agents: A Review article

2015

Ther Targets Neurol Dis

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Failed back surgery syndrome (FBSS) is a severe, long lasting and very common complication of lumbosacral spine surgery. FBSS can result from a variety of factors, such as an incorrect level of surgery, inadequate surgical decompression, recurrent disc herniation and epidural nerve fibrosis. The primary objective of this study was to present the recent data from animal and clinical studies regarding a variety of biological, pharmacological, and different synthetic materials used to prevent scar formation after spine surgery. There are a substantial number of substances that are topically used on the dura mater to prevent epidural fibrosis; however, we have primarily selected the substances that are used most often, such as hyaluronic acid (HA) and its derivatives, mitomycin C (MMC), 5-fluorouracil (5-FU), tacrolimus, melatonin (MLT), and nonsteroidal anti-inflammatory drugs (NSAIDs). Other biological and synthetic materials are also presented, which are used locally in the dura mater but act as mechanical barriers, such as Adcon-L, amniotic membrane (AM), carboxymethylcellulose and polyethylene oxide (CMC/PEO), polytetrafluoroethylene (PTFE), chitosan, collagen dural matrix, polyethylene glycol hydrogel, and fibrin sealant-based medicated adhesion barrier. As indicated in this review paper, the results regarding the use of these substances and barriers in animal models and humans are different; their effects have not always been successful, and they may have even caused adverse effects. However, it is necessary to identify adequate chemical, biological, and synthetic substances that are more successful in the prevention of epidural fibrosis, which is considered one of the main causes of FBSS.

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Effect of oxiplex∗ films (PEO/CMC) on adhesion formation and reformation in rabbit models and on peritoneal infection in a rat model

Cited by 53 publications

References 20 publications

Comparison of Oxiplex and Gore-Tex effectivity in an experimental peridural fibrosis model

Comparison of Oxiplex and Gore-Tex effectivity in an experimental peridural fibrosis model

Inibição da formação de abscesso abdominal em rato: mortalidade por sepse

Prevention of failed back surgery syndrome with applications of different pharmacological agents: A Review article

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