Aim. The article deals with the assessment of the lipid profile, lipid peroxidation, and antioxidant protection in freestyle wrestlers belonging to different ethnic groups. Materials and methods. The study involved freestyle male wrestlers aged 18–22 with the rank of the Candidate for Master of Sport and Master of Sport regularly practicing freestyle wrestling. We studied a serum consisting of blood plasma and erythrocyte hemolysate. Lipid exchange was studied with the help of the BTS-350 analyzer (Spain) and BioSystems (Spain) reagents. To establish aminotransferase in blood serum, we used Vital (Russia) reagents. The components of lipid peroxidation and antioxidant protection were established with the help of spectrophotometric and fluorometric methods. Results. Freestyle athletes of the Russian ethnic group are characterized by a significantly lower TG concentrations compared to Buryat athletes. In the system of lipid peroxidation and antioxidant protection, in athletes of the Russian ethnic group, we revealed a significant AOA, reduced glutathione and retinol compared to Buryat athletes. Conclusion. The data obtained prove a different degree of metabolic activity in athletes from various ethnic groups. The balance between lipid oxidation and antioxidant protection mostly determines metabolic intensity as well as adaptation capacities of the body. The study of metabolic changes in highly-skilled athletes from different ethnic groups can contribute to the deepening of knowledge about the physiological basis and pathogenetic effects of stress on the human body. This will be one of the factors for optimizing training and providing the search for the ways of increasing physical activity as a mean of preserving the nation and sports development.