Effect of Ovine Hydatid Cyst Fluid on the Cardiovascular and Respiratory Systems in Sheep

Abstract

Rupture of the hydatid cyst in man brings about mild to severe toxic reactions including death. The present study was undertaken to investigate some of the responses resulting from administration of the ovine hydatid fluid to the sheep, which, like man, is an interme diate host of the Echinococcus granulosus. In 50 sodium pentobarbital-anesthetized sheep, the arterial blood pressure (A.B.P.), •central venous pressure (C.V.P.), respiration and electrocardiogram were recorded. Intravenous administration of 5-10 ml hydatid fluid brought about moderate to severe fall in A.B.P. and rapid respiration with or without transient apnea or permanent respira tory cessation in 80 percent of the animals. Fifty percent of the sheep died of circulatory and respiratory failure after the first injection of the hydatid fluid. Boiled hydatid fluid did not lose its potency to evoke the above responses. Pretreatment of the animals with atropine sulfate, 0,5 mg/kg subcutaneously, did not block the reactions. Administration of the antihistamine chlorpheniramine, 4 mg/kg intravenously, caused partial prevention of the reactions in 6 out of 10 responsive sheep. The cardiovascular and respiratory responses to ovine hydatid fluid may be due to antigen-antibody reactions or some toxic component of the fluid. Résumé. Effet du fluide hydatique ovin sur les systèmes cardio-vasculaire et respiratoire des moutons. La rupture du kyste hydatique chez l'homme provoque une réaction toxique d'une intensité modérée à très sévère, parfois même mortelle. La présente étude a pour but d'éta-(1) This investigation was supported by grants from the Iranian Ministry of Science, the Iran Foundation and the Pahlavie University.

Effects of saline extract of ovine hydatid Cyst scoleces in Sheep

“…Experimentally, administra tion of the ovine hydatid fluid to laboratory animals such as cats, dogs and sheep produces hypotension, cardiac arhythmia, rapid respiration and death (6)(7)(8)(9)(10). Within the hydatid cyst, there are scoleces whose products contribute to the hydatid fluid contents.…”