Effect of ovarian steroids and diethylstilbestrol on the contractile responses of the human myometrium and intramyometrial arteries

Kostrzewska, Anna; Laudański, T; Batra, Satish

doi:10.1016/0014-2999(93)90358-o

Cited by 39 publications

(14 citation statements)

References 25 publications

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“…In the present report, systemic administration of a potent cyclooxygenase inhibitor, using a dose shown to inhibit prostanoid synthesis in pregnant ewes (21,22), had no effect on either the acute uterine or systemic responses to E 2 ␤. Others have reported that estrogen may also affect smooth muscle tone or responsiveness through endothelium-independent mechanisms (41) and altered fluxes of smooth muscle calcium and/or potassium (42)(43)(44)(45)(46)(47). In particular, White et al (47) recently reported that E 2 ␤ relaxes porcine coronary artery smooth muscle within 5-10 min through an endothelium-independent mechanism involving K ϩ efflux via a calcium-dependent K ϩ channel and a cGMP-dependent mechanism.…”

Section: Discussionmentioning

confidence: 99%

Nitric oxide contributes to estrogen-induced vasodilation of the ovine uterine circulation.

Rosenfeld¹,

Cox²,

Roy³

et al. 1996

J. Clin. Invest.

203

193

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Estradiol-17 ␤ (E 2 ␤ ), a potent vasodilator, has its greatest effects on the uterine vasculature, blood flow (UBF) increasing Ն 10-fold. The mechanism(s) responsible for E 2 ␤ -induced vasodilation is unclear. We determined if nitric oxide (NO)-induced increases in cGMP modulate estrogen-induced increases in UBF, and if cyclooxygenase inhibition modifies E 2 ␤ responses. Nonpregnant ( n ϭ 15) and pregnant ( n ϭ 8) ewes had flow probes implanted on main uterine arteries and catheters in branches of the uterine vein and artery bilaterally for blood sampling and infusion of the NO synthase inhibitor L -nitro-arginine methyl ester ( L -NAME), respectively. In nonpregnant ewes E 2 ␤ (1 g/kg) caused parallel increases ( P Ͻ 0.001) in UBF (15 Ϯ 3 to 130 Ϯ 16 ml/ min) and uterine cGMP secretion (23 Ϯ 10 to 291 Ϯ 38 pmol/ min); uterine venous cGMP also rose (4.98 Ϯ 1.4 to 9.43 Ϯ 3.2 pmol/ml; P Ͻ 0.001). Intra-arterial L -NAME partially inhibited increases in UBF dose-dependently (r ϭ 0.66, n ϭ 18, P Յ 0.003) while completely inhibiting cGMP secretion ( P ϭ 0.025). Indomethacin, 2 mg/kg intravenously, did not alter E 2 ␤ -induced responses. After E 2 ␤ -induced increases in UBF, intraarterial L -NAME partially decreased UBF dose dependently (r ϭ 0.73, n ϭ 46, P Ͻ 0.001) while inhibiting cGMP secretion (178 Ϯ 48 to 50 Ϯ 24 pmol/min; n ϭ 5, P ϭ 0.006); both were reversed by L -arginine. In pregnant ewes, E 2 ␤ increased UBF and venous cGMP (9.1 Ϯ 0.96 to 13.2 Ϯ 0.96 pmol/ml, P Ͻ 0.01); however, intraarterial L -NAME decreased basal cGMP secretion 66% (P ϭ 0.02), but not UBF. Acute estrogen-induced increases in UBF are associated with NO-dependent increases in cGMP synthesis, but other mechanisms may also be involved. However, vasodilating prostanoids do not appear to be important. In ovine pregnancy NO is not essential for maintaining uteroplacental vasodilation. ( J. Clin. Invest. 1996. 98:2158-2166.)

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Section: Discussionmentioning

confidence: 99%

Nitric oxide contributes to estrogen-induced vasodilation of the ovine uterine circulation.

Rosenfeld¹,

Cox²,

Roy³

et al. 1996

J. Clin. Invest.

203

193

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“…Placental steroids are obvious candidates and numerous studies of animal myometrium have reported modulation of a variety of CAPs and their activity by oestrogen and/or progesterone (Rendt et al 1992;Rezapour et al 1996;Capriani et al 1997;Inoue et al 1999). With regard to calcium homeostasis, progesterone, oestrogen and oestriol have been reported to modify agonistinduced calcium signalling in term pregnant human myometrium (Kostrzewska et al 1993;Fujii & Oku, 1995;Fomin et al 1999), and oestrogen appears to alter Ca 2+ channels expression and function (Batra, 1987;Mershon et al 1994), mitochondrial calcium uptake (Batra, 1973) and Ca 2+ -ATPase activity in animal myometrium (Missiaen et al 1988). The effect of placental steroids on Ca 2+ -ATPases in human myometrium has not been fully determined.…”

Section: Placental Steroidsmentioning

confidence: 99%

Regulation of Human Myometrial Contractility During Pregnancy and Labour: Are Calcium Homeostatic Pathways Important?

Tribe

2001

Experimental Physiology

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If we are to develop new strategies for the treatment and management of preterm and dysfunctional term labour, it is imperative that we improve current understanding of the control of human uterine activity. Despite many studies of animal pregnancy, there is a paucity of knowledge relating to the complex control of human myometrium during pregnancy. It is hypothesized that human myometrium is relatively quiescent during the majority of pregnancy and that as term approaches there is cascade of molecular events that prepare the uterus for labour. This review will consider the cellular mechanisms involved in the regulation of human myometrial activity and the modulation of these by hormonal and mechanical signals. In particular, the contribution of calcium homeostatic pathways to the control of human myometrial contractility during gestation will be discussed. Experimental Physiology (2001) 86.2, 247-254. 2180

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“…It has been shown that arginine vasopressin (AVP) induces contraction of the human uterine artery (Svane et al, 1990;Ekesbo et al, 1991;Nelson & Suresh, 1992;Kostrzewska et al, 1993), as opposed to some other arteries in which AVP evokes relaxation (Katusic et al, 1984;Seino et al, 1985;Evora et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Characterization of arginine vasopressin actions in human uterine artery: lack of role of the vascular endothelium

Jovanović

Grbović

Žikić

et al. 1995

British J Pharmacology

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Effect of ovarian steroids and diethylstilbestrol on the contractile responses of the human myometrium and intramyometrial arteries

Cited by 39 publications

References 25 publications

Nitric oxide contributes to estrogen-induced vasodilation of the ovine uterine circulation.

Nitric oxide contributes to estrogen-induced vasodilation of the ovine uterine circulation.

Regulation of Human Myometrial Contractility During Pregnancy and Labour: Are Calcium Homeostatic Pathways Important?

Characterization of arginine vasopressin actions in human uterine artery: lack of role of the vascular endothelium

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