Effect of outer membrane vesicle vaccine against group B meningococcal disease in Norway

Bjune, Gunnar; Høiby, E. Arne; Grønnesby, Jon Ketil; Arnesen, Øyvind; Fredriksen, J. H.; Lindbak, A-K; Nøkleby, Hanne; Rosenqvist, Einar; Solberg, L.K; Closs, O; Frøholm, L. O.; Lystad, A; Bakketeig, Leiv S.; Hareide, B; Halstensen, Alfred; Holten, Eirik; Eng, Jan

doi:10.1016/0140-6736(91)91961-s

Cited by 626 publications

(399 citation statements)

References 5 publications

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“…Most interestingly, while adjuvants such as CT and ISCOM are yet to be licensed for human use due to safety concerns, OMV are currently used as parenteral vaccines against meningitis in infants as young as 2 months of age [31][32][33]. Although a number of safety concerns have been related to their use as adjuvants, particularly the amount of LPS contained within the vesicles, it is clear that both NOMV and DOMV are safe when given intranasally to adults [34,35].…”

Section: Discussionmentioning

confidence: 99%

Intranasal immunisation with inactivated RSV and bacterial adjuvants induces mucosal protection and abrogates eosinophilia upon challenge

et al. 2006

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We have previously shown that following intranasal exposure to influenza virus, specific plasma cells are generated in the nasal-associated lymphoid tissue (NALT) and maintained for the life of the animal. However, we also showed that following infection with respiratory syncytial virus (RSV), specific plasma cells are generated in the NALT but wane quickly and are not maintained even after challenge, even though RSVspecific serum antibody responses remain robust. Only infection with influenza virus generated sterilising immunity, implying a role for these long-lived plasma cells in protection. We show here that the RSV-specific IgA NALT plasma cell population and lung antibody levels can be substantially boosted, both at acute and memory time points, by intranasal immunisation with inactivated RSV (iRSV) in combination with bacterial outer membrane vesicles (OMV) compared to live RSV alone. Finally, challenge with live RSV showed that immunisation with iRSV and OMV protect against both virus replication in the lung and the eosinophil infiltrate generated by either live RSV or iRSV alone. These data show that immunisation with iRSV and OMV maintains a NALT RSV-specific plasma cell population and generates an efficient protective immune response following RSV infection.See accompanying commentary: http://dx

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Section: Discussionmentioning

confidence: 99%

Intranasal immunisation with inactivated RSV and bacterial adjuvants induces mucosal protection and abrogates eosinophilia upon challenge

et al. 2006

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“…Six years later, a tetravalent conjugate meningococcal vaccine, including the capsular polysaccharides of serogroups A, C, Y and W-135, was licensed for use among persons aged 11-55 years (Bilukha and Rosenstein, 2005). Despite these advances, an effective vaccine against serogroup B, a major cause of invasive meningococcal disease in many European countries and the Americas, is not currently available (Bjune et al, 1991;De Moraes et al, 1992;Sierra et al, 1991;Tappero et al, 1999;Tsolia et al, 2006). Future prevention of serogroup B disease will rely both on outer membrane vesicle (OMV) vaccines being used for specific serosubtypes and new vaccines containing multiple other antigens.…”

Section: Introductionmentioning

confidence: 99%

Hospital-based surveillance of meningococcal meningitis in Salvador, Brazil

Cordeiro

Neves

Ribeiro

et al. 2007

Transactions of the Royal Society of Tropical Medicine and Hygi

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SummaryThis study aimed to describe the clinical, epidemiological and microbiological features of meningococcal meningitis in Salvador, Brazil. Between February 1996 and January 2001, a hospitalbased surveillance prospectively identified cases of culture-positive meningococcal meningitis. Demographic and clinical data were collected through interview and medical chart review. Antisera and monoclonal antibodies were used to determine the serogroup and serotype:serosubtype of the isolates, respectively. Surveillance identified a total of 408 cases of meningococcal meningitis, with a case fatality rate of 8% (32/397). The mean annual incidence for the 304 culture-positive cases residing in metropolitan Salvador was 1.71 cases per 100 000 population. Infants <1 year old presented the highest incidence (14.7 cases per 100 000 population). Of the 377 serogrouped isolates, 82%, 16%, 2% and 0.3% were serogroups B, C, W135 and Y, respectively. A single serotype:serosubtype (4,7:P1.19,15) accounted for 64% of all cases. Continued surveillance is necessary to characterise strains and to define future prevention and control strategies.

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“…Vaccines against Neisseria meningitidis serogroup B, the most prevalent pathogenic strains in Britain, are not sufficiently developed for mass immunization programmes [2]. Antibiotic prophylaxis of close contacts is of uncertain efficacy and has not been tested by controlled trial [3].…”

Section: Introductionmentioning

confidence: 99%

Smoking, the environment and meningococcal disease: a case control study

Stuart²,

et al. 1994

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SUMMARYThis case control study investigated environmental factors in 74 confirmed cases of meningococcal disease (MD). In children aged under 5, passive smoking in the home (30 or more cigarettes daily) was associated with an odds ratio (OR) of 7 5 (95% confidence interval (CI) 1P46-38-66). ORs increased both with the numbers of cigarettes smoked and with the number of smokers in the household, suggesting a dose-response relationship. MD in this age group was also significantly associated with household overcrowding (more than 1P5 persons per room) (OR 60, 95% CI 110-32-8), with kisses on the mouth with 4 or more contacts in the previous 2 weeks (OR 2-46, 95% CI 1P09-5 56), with exposure to dust from plaster, brick or stone in the previous 2 weeks (OR 2-24, 95 % CI 107-465); and with changes in residence (OR 30, 95% CI 1P0-899), marital arguments (OR 3-0, 95 % CI 1P26-7 17) and legal disputes in the previous 6 months (OR 3-10, 95% CI 1P24-7 78). These associations were independent of social class. Public health measures to lower the prevalence of cigarette smoking by parents of young children may reduce the incidence of MD. The influence of building dust and stressful life events merits further investigation.

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Effect of outer membrane vesicle vaccine against group B meningococcal disease in Norway

Cited by 626 publications

References 5 publications

Intranasal immunisation with inactivated RSV and bacterial adjuvants induces mucosal protection and abrogates eosinophilia upon challenge

Intranasal immunisation with inactivated RSV and bacterial adjuvants induces mucosal protection and abrogates eosinophilia upon challenge

Hospital-based surveillance of meningococcal meningitis in Salvador, Brazil

Smoking, the environment and meningococcal disease: a case control study

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