Effect of oseltamivir and some vitamins on Dopamine, GSH and Lipid Peroxidation levels in young animal models exposed to O3

Abstract

Oseltamivir is used for the treatment of AH1N1 swine influenza in Mexico. The aim of the present study was to analyze the effect of oseltamivir on dopamine levels in patients exposed to vitamins A, D, and C as well as to ozone. For this, forty male Wistar rats (80 g) were divided into 6 groups. A combination of oseltamivir (20 vmg/kg) with A (39 v0UI.), C (30 mg) and D (60 UI.) vitamins with or without ozone 0.5 ppm were intraperitoneally administered for 5 days. The exposition to ozone was through a camera controlled. The animals were sacrificed and the brain dissected in cortex (I), hemispheres (II) and cerebellum/medulla oblongata (III) to measure dopamine, glutathione (GSH) and lipoperoxidation using fluorescence. Dopamine increased in I, II and III regions while GSH increased only in II and III regions and lipoperoxidation decreased in the same regions. This changes were significant (p < 0.05) in the groups that received oseltamivir and ozone. Administration of oseltamivir and ozone induces synergic effect on dopamine metabolism.

Oleic Acid Reduces Brain Injury by Oxidative Stress Induced by Some Anticancer Drugs in Rat Brain

“…Likewise, in recent years, malignant tumor morbidity has gone up as depicted in the ´90s report where it was shown that malignant tumor in adult females and males of 30 years old rose to 63.5% and 35.3% respectively [2,6]. Besides, malignant tumors have been reckoned as the main cause of death in pediatric population under 15 years old [2,7]. The treatment most widely used in cancer therapy focuses on drugs that target on fast growing and dividing cancerous cells and most of these drugs have been associated to an increase in monoamine concentrations in the brain [2,8].…”

“…old [2,3]. Metabolic syndrome (MS) is a group of conditions characterized high abdominal fat accumulation, high systolic and diastolic blood pressure, high density lipid cholesterol, and high blood glucose and triglycerides [2,4].…”

“…Metabolic syndrome (MS) is a group of conditions characterized high abdominal fat accumulation, high systolic and diastolic blood pressure, high density lipid cholesterol, and high blood glucose and triglycerides [2,4]. Irrational consumption of fatty foods and meats has been linked with oxidative stress with its concomitant adverse health effects and as an important risk factor for the development of cancer [2,5]. In Mexico, oncological diseases rank second as the principal cause of death in the general population.…”

“…The toll of cancer mortality in the country had been witnessing an increase since 1953 in such way that by 1998, it had registered an accumulated rise of 68%, a figure that may have increased today. Likewise, in recent years, malignant tumor morbidity has gone up as depicted in the ´90s report where it was shown that malignant tumor in adult females and males of 30 years old rose to 63.5% and 35.3% respectively [2,6]. Besides, malignant tumors have been reckoned as the main cause of death in pediatric population under 15 years old [2,7].…”

“…Besides, malignant tumors have been reckoned as the main cause of death in pediatric population under 15 years old [2,7]. The treatment most widely used in cancer therapy focuses on drugs that target on fast growing and dividing cancerous cells and most of these drugs have been associated to an increase in monoamine concentrations in the brain [2,8]. In any case, these drugs eliminate these cells in specific points of cell cycle [2,9].…”