Effect of oropharyngeal decontamination by povidone-iodine on ventilator-associated pneumonia in patients with head trauma*

Séguin, Philippe; Tanguy, M.; Laviolle, Bruno; Tirel, O.; Mallédant, Yannick

doi:10.1097/01.ccm.0000214516.73076.82

Cited by 91 publications

(72 citation statements)

References 37 publications

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“…Providoneiodine and iseganan have only been evaluated in one trial each. The providone-iodine trial showed a decrease in VAP rates but no impact on patient outcomes [62]. The trial of iseganan showed no impact on either VAP rates or patient outcomes [63].…”

Section: Oral Antiseptics and Antibioticsmentioning

confidence: 99%

Prevention of ventilator-associated pneumonia

Klompas¹

2010

Expert Review of Anti-infective Therapy

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Section: Oral Antiseptics and Antibioticsmentioning

confidence: 99%

Prevention of ventilator-associated pneumonia

Klompas¹

2010

Expert Review of Anti-infective Therapy

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“…For example, chlorhexidine is employed because of its high level of antibacterial, antiviral, and antifun-gal activities and high substantivity (ability to bind to oral tissues with subsequent slow release of antiseptic properties and therefore a long period of antibacterial action). 8,9 Although generally safe, chlorhexidine is not free of adverse events.…”

Section: Introductionmentioning

confidence: 99%

Effect of Oral Hygiene and 0.12% Chlorhexidine Gluconate Oral Rinse in Preventing Ventilator-Associated Pneumonia After Cardiovascular Surgery

et al. 2013

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BACKGROUND: Ventilator-associated pneumonia (VAP) is a nosocomial infection of multifactorial etiology and has a negative influence on cardiovascular surgery (CVS) outcomes. OBJECTIVES: Determine the effect of toothbrushing plus 0.12% chlorhexidine gluconate oral rinse in preventing VAP after CVS. METHODS: In a quasi-experimental study, patients undergoing heart surgery were enrolled in a protocol for controlling dental biofilm by proper oral hygiene (toothbrushing) and oral rinses with 0.12% chlorhexidine gluconate (Group 1), and they were compared with a historical control group (Group 2), which included patients who underwent cardiac surgery be-

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“…The daily risk of VAP was reduced in both treatment groups compared with placebo, to 65% for chlorhexidine and 55% for chlorhexidine and colistin. Another prospective, randomised study evaluated the effect of oropharyngeal decontamination by povidoneiodine on VAP in 98 patients with head trauma [6]. The study found a significant reduction in the rate of VAP in the povidone-iodine group when compared with the saline and control groups.…”

mentioning

confidence: 90%