Effect of orientation and density of nanotopography in dermal wound healing

Kim, Hong Nam; Hong, Yoonmi; Kim, Min Sung; Kim, Sun Min; Suh, Kune Y.

doi:10.1016/j.biomaterials.2012.08.038

Cited by 138 publications

(131 citation statements)

References 44 publications

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“…One would presume that the same fabrication techniques used by other research groups to construct nanoscale topographies for studies with mammalian cells, could just as easily be adopted for the use of bacterial cells. However, many of those nanostructured surfaces were fabricated with the intent of replicating the 3D scaffold-like structure of the extra cellular matrix (ECM) in efforts of promoting mammalian cell differentiation and proliferation [93][94][95][96][97]. This is quite different than the motivation for antifouling work, which focuses on limiting and preventing bacterial attachment to surfaces.…”

Section: Pushing Antifouling Topography To the Nanoscalementioning

confidence: 99%

Nano and Microscale Topographies for the Prevention of Bacterial Surface Fouling

2014

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Bacterial surface fouling is problematic for a wide range of applications and industries, including, but not limited to medical devices (implants, replacement joints, stents, pacemakers), municipal infrastructure (pipes, wastewater treatment), food production (food processing surfaces, processing equipment), and transportation (ship hulls, aircraft fuel tanks). One method to combat bacterial biofouling is to modify the topographical structure of the surface in question, thereby limiting the ability of individual cells to attach to the surface, colonize, and form biofilms. Multiple research groups have demonstrated that micro and nanoscale topographies significantly reduce bacterial biofouling, for both individual cells and bacterial biofilms. Antifouling strategies that utilize engineered topographical surface features with well-defined dimensions and shapes have demonstrated a greater degree of controllable inhibition over initial cell attachment, in comparison to undefined, texturized, or porous surfaces. This review article will explore the various approaches and techniques used by researches, including work from our own group, and the underlying physical properties of these highly structured, engineered micro/nanoscale topographies that significantly impact bacterial surface attachment.

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Section: Pushing Antifouling Topography To the Nanoscalementioning

confidence: 99%

Nano and Microscale Topographies for the Prevention of Bacterial Surface Fouling

2014

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“…Topographical features in the shape of grooves have been shown to guide nondirectional cell migration along the main axis of grooves in both directions, in a mechanism known as contact guidance (7)(8)(9)(10)(11). In these situations, cells align according to features much smaller than the size of the cell itself by attaching mainly to the top of the topographical structures (7,10,11).…”

Section: Introductionmentioning

confidence: 98%

Cells as Active Particles in Asymmetric Potentials: Motility under External Gradients

Comelles

Caballero

Voituriez

et al. 2014

Biophysical Journal

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Cell migration is a crucial event during development and in disease. Mechanical constraints and chemical gradients can contribute to the establishment of cell direction, but their respective roles remain poorly understood. Using a microfabricated topographical ratchet, we show that the nucleus dictates the direction of cell movement through mechanical guidance by its environment. We demonstrate that this direction can be tuned by combining the topographical ratchet with a biochemical gradient of fibronectin adhesion. We report competition and cooperation between the two external cues. We also quantitatively compare the measurements associated with the trajectory of a model that treats cells as fluctuating particles trapped in a periodic asymmetric potential. We show that the cell nucleus contributes to the strength of the trap, whereas cell protrusions guided by the adhesive gradients add a constant tunable bias to the direction of cell motion.

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“…169 Specifically, micropatterned surfaces with arrayed grooves or cell-recognizable adhesion sites have been utilized to guide skin cell migration in vitro, mimicking reepithelialization in vivo. [170][171][172] Using photolithography, Kim et al made nanogrooves with various spacing distances and found an optimal spacing ratio to promote fibroblasts migration, proliferation, and ECM deposition. 171 migration 170 ( Fig.…”

Section: Biophysical Cuesmentioning

confidence: 99%

“…[170][171][172] Using photolithography, Kim et al made nanogrooves with various spacing distances and found an optimal spacing ratio to promote fibroblasts migration, proliferation, and ECM deposition. 171 migration 170 ( Fig. 2a).…”

Section: Biophysical Cuesmentioning

confidence: 99%

Biochemical and Biophysical Cues in Matrix Design for Chronic and Diabetic Wound Treatment

Xiao

Ahadian

Radišić

2017

Tissue Engineering Part B: Reviews

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Progress in biomaterial science and engineering and increasing knowledge in cell biology have enabled us to develop functional biomaterials providing appropriate biochemical and biophysical cues for tissue regeneration applications. Tissue regeneration is particularly important to treat chronic wounds of people with diabetes. Understanding and controlling the cellular microenvironment of the wound tissue are important to improve the wound healing process. In this study, we review different biochemical (e.g., growth factors, peptides, DNA, and RNA) and biophysical (e.g., topographical guidance, pressure, electrical stimulation, and pulsed electromagnetic field) cues providing a functional and instructive acellular matrix to heal diabetic chronic wounds. The biochemical and biophysical signals generally regulate cell-matrix interactions and cell behavior and function inducing the tissue regeneration for chronic wounds. Some technologies and devices have already been developed and used in the clinic employing biochemical and biophysical cues for wound healing applications. These technologies can be integrated with smart biomaterials to deliver therapeutic agents to the wound tissue in a precise and controllable manner. This review provides useful guidance in understanding molecular mechanisms and signals in the healing of diabetic chronic wounds and in designing instructive biomaterials to treat them.

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Effect of orientation and density of nanotopography in dermal wound healing

Cited by 138 publications

References 44 publications

Nano and Microscale Topographies for the Prevention of Bacterial Surface Fouling

Nano and Microscale Topographies for the Prevention of Bacterial Surface Fouling

Cells as Active Particles in Asymmetric Potentials: Motility under External Gradients

Biochemical and Biophysical Cues in Matrix Design for Chronic and Diabetic Wound Treatment

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