Effect of organic/inorganic nanoparticles on performance of polyurethane nanocomposites for potential wound dressing applications

Jafari, Arman; Hassanajili, Shadi; Karimi, Mohammad; Emami, Amir; Ghaffari, Farnaz; Azarpira, Negar

doi:10.1016/j.jmbbm.2018.09.001

Cited by 45 publications

(25 citation statements)

References 53 publications

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“…The PU/TiO 2 /graphene hybrid nanocomposites showed an antibacterial rate of approximately 99% against both S. aureus and E. coli bacteria. Jafari et al 104 fabricated chitosan-and TiO 2 NPs-incorporated PU nanocomposites. Chitosan and TiO 2 NPs have different antibacterial mechanisms.…”

Section: Other Metal and Metal Oxide Nanoparticles-incorporated Polyu...mentioning

confidence: 99%

Polyurethane‐basedcomposites with promising antibacterial properties

Kasi

Sathishkumar

Zhang

et al. 2022

J of Applied Polymer Sci

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Polyurethane (PU) is a well-known synthetic polymer consisting of isocyanates, polyols, and chain extenders. The incorporation of fillers into the PU polymeric matrix, including inorganic nanomaterials, synthetic polymers, natural components, quaternary ammonium salts, and commercial drugs, bestows the endproducts with unique and improved physicochemical properties. Fillers can be used to tailor the molecular orientation, crystallinity, cross-linking, and functional chemical groups of PU-based composites. The bactericidal ability of PU composites highly depends on their surface composition, morphology, charge, and stability. Recent advancements highlight the potential of PU composites in combating bacterial infections. In this review, the cutting-edge of inorganic and organicbased PU composites for antibacterial applications is addressed. Notably, selective examples of scientific reports' key findings and their crucial information on PU composites are discussed. Furthermore, the positive impact of PU composites on the future prospects of this field is explored. This review comprehensively deliberates the values of PU composites towards practical applications in the biomedical field of antibacterial activity. This review can help researchers to gain widespread knowledge and a better understanding of PU composites for antibacterial applications.

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Section: Other Metal and Metal Oxide Nanoparticles-incorporated Polyu...mentioning

confidence: 99%

Polyurethane‐basedcomposites with promising antibacterial properties

Kasi

Sathishkumar

Zhang

et al. 2022

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…Figure 2a presented the recorded spectra of samples and pure components for outer layer fibers. In the FT‐IR spectrum of chitosan a broad absorbance bands were observed at 3,330 cm −1 and two absorbance bands at 1,653 and 1,065 cm −1 corresponding to OH, NH, and ether functional groups, respectively 61 . PVA demonstrated characteristic absorbance bands at 3,330 cm −1 (OH stretching), 2,947 cm −1 (CH stretching), 1,710 cm −1 (CO stretching), 1,422 cm −1 (CH bending) and 1,092 cm −1 62 .…”

Section: Resultsmentioning

confidence: 99%

Preparation of multilayer electrospun nanofibrous scaffolds containing soluble eggshell membrane as potential dermal substitute

Amirsadeghi

Khorram

Hashemi

2021

J Biomedical Materials Res

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Electrospinning of natural and synthetic polymers has shown to be a great candidate for the fabrication of tissue engineering scaffolds due to their similarity to the nanofibrous structure of natural extracellular matrix (ECM). Moreover, the addition of ECM‐like proteins could enhance the biocompatibility of these scaffolds. In this study, soluble eggshell protein (SEP) was first extracted and synthesized from the raw eggshell membrane. The characteristics and biocompatibility of the extracted SEP were evaluated using attenuated total reflectance‐Fourier transform infrared (ATR‐FTIR) analysis and 3‐(4,5‐ dimethylthiazol‐2‐yl‐2,5‐diphenyltetrazolium bromide) (MTT) assay. For scaffolds fabrication, a three‐layer nanofibrous composite structure was produced using the electrospinning technique. The outer layers composed of polyvinyl alcohol, chitosan, and extracted SEP while the middle layer composed of polyethylene oxide, gelatin, and zinc oxide nanoparticles (ZnO‐NPs). For each layer, the electrospinning parameters were adjusted to form bead‐free fibers. To improve fibers' stability against body fluids, the produced fibers were crosslinked using glutaraldehyde vapor. Several techniques such as scanning electron microscopy (SEM), energy dispersive X‐ray, ATR‐FTIR, swelling, tensile test, in vitro biodegradation, and MTT assay were implemented to evaluate the physical, chemical, and biological characterization of the fabricated fibers. The results showed that crosslinked fibers have adequate stability in water, suitable mechanical properties, and promising water uptake capacity. The MTT results also revealed that SEP and ZnO‐NPs could increase scaffolds biocompatibility. Moreover, SEM photographs of cultured fibroblasts cells on the scaffolds showed that cells were well attached on the scaffolds and preserve their natural spindle shapes. Altogether, our findings demonstrated that the produced three‐layer composite scaffolds are potential candidates for skin tissue engineering.

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“…Especially for MBG-3, there were microstructures dispersed uniformly on the fracture surface at the scale of several microns, which indicates the toughness of tensile breaking. The interaction between nanoparticles and polymer chains and the uniform distribution of nanoparticles in the cross-linked network are the keys for the enhancement of tensile modulus. , The amine-terminated MSNs participate in the cross-linking reaction, thus leading to a more uniform and stable dispersion in the final network compared to physical doping. In addition, the interaction between MSNs and polymer chains, i.e., entanglement, is also strengthened.…”

Section: Resultsmentioning

confidence: 99%

Injectable Multicomponent Biomimetic Gel Composed of Inter-Crosslinked Dendrimeric and Mesoporous Silica Nanoparticles Exhibits Highly Tunable Elasticity and Dual Drug Release Capacity

Wang

et al. 2020

ACS Appl. Mater. Interfaces

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There is a growing need for cartilage defect grafts that are structurally adaptable to possess multifaceted functions to promote bone regeneration, sustain medication efficacy, and preferably remain injectable but solidify quickly upon injection. In this work, we developed an injectable multicomponent biomimetic gel (MBG) by integrating polyamidoamine dendrimer G3 (G3), mesoporous silica nanoparticles (MSNs), and dendrimertemplated silver nanoparticles (G3-Ag) into a well-defined cross-linked network. MBGs composed of one particulate component (G3 alone), i.e., MBG-1, two particulate components (G3 and MSN-NH 2 ), i.e., MBG-2, and three particulate components (G3, MSN-NH 2 , and G3-Ag), i.e., MBG-3, were prepared by intercross-linking dendrimeric and mesoporous silica nanoparticles with poly(ethylene glycol) diglycidyl ether (PEG-DGE, M n = 2000 g/mol) via the facile amine−epoxy click reaction. The water-soluble antibiotic isoniazid was loaded to the cross-linked PEG network, whereas the hydrophobic antibiotic rifampicin was encapsulated into mesoporous MSNs. Our studies revealed that elasticity and mechanical strengths could be modulated and enhanced significantly with the inclusion of MSNs and silver nanoparticles. Isoniazid was released rapidly while rifampicin was released over an extended period of time. In addition, MBGs showed injectability, high swelling capacity, structural stability, and cytocompatibility. Taken together, MBGs have shown structural features that allow for the development of injectable gel grafts with the ability to promote cartilage defect repair and offer antibiotic medication benefits.

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Effect of organic/inorganic nanoparticles on performance of polyurethane nanocomposites for potential wound dressing applications

Cited by 45 publications

References 53 publications

Polyurethane‐basedcomposites with promising antibacterial properties

Polyurethane‐basedcomposites with promising antibacterial properties

Preparation of multilayer electrospun nanofibrous scaffolds containing soluble eggshell membrane as potential dermal substitute

Injectable Multicomponent Biomimetic Gel Composed of Inter-Crosslinked Dendrimeric and Mesoporous Silica Nanoparticles Exhibits Highly Tunable Elasticity and Dual Drug Release Capacity

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